Primary Subcutaneous Phaeohyphomycosis Caused by Cladosporium cladosporioides

AbstractCladosporium cladosporioides causes asthma and superficial and deep infections, mostly in immunodeficient individuals and animals. This study aimed to investigate whether C. cladosporioides spores can enter the lungs through pulmonary circulation and influence pulmonary immune response. We intravenously injected mice with C. cladosporioides spore suspension and conducted several assays on the lungs. Pulmonary hemorrhage symptoms and congestion were most severe on days 1, 2, and 3 post-inoculation (PI). Extensive inflammatory cell infiltration occurred throughout the period of infection. More spores and hyphae colonizing the lungs were detected on days 1, 2, and 3 PI, and fewer spores and hyphae were observed within 21 d of infection. Numerous macrophages, dendritic cells, and neutrophils were observed on day 5 PI, along with upregulation of CD54, an intercellular adhesion molecule. Th1 and Th2 cells increased after infection; specifically, Th2 cells increased considerably on day 5 PI. These results suggest that days 2 and 5 PI represent the inflammatory peak in the lungs and that the Th2 and Th1 signaling pathways are potentially involved in pulmonary immune responses. In conclusion, the further adaptive immune responses played important roles in establishing effective pulmonary immunity against C. cladosporioides systemic infections based on innate immune responses.

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CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2013.09.033 ◽

2014 ◽

Vol 133 (3) ◽

pp. 905-908.e3 ◽

Cited By ~ 75

Author(s):

Xiaowen Wang ◽

Wenyan Wang ◽

Zhimiao Lin ◽

Xiaolin Wang ◽

Ting Li ◽

...

Keyword(s):

Th17 Cell ◽

Subcutaneous Phaeohyphomycosis

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Two cases of subcutaneous phaeohyphomycosis due to Exophiala jeanselmei, in cardiac transplant and renal transplant patients

British Journal of Dermatology ◽

10.1111/j.1365-2133.2003.05794.x ◽

2004 ◽

Vol 150 (3) ◽

pp. 597-598 ◽

Cited By ~ 19

Author(s):

F. de Monbrison ◽

M.A. Piens ◽

B. Ample ◽

S. Euvrard ◽

P. Cochat ◽

...

Keyword(s):

Renal Transplant ◽

Cardiac Transplant ◽

Transplant Patients ◽

Exophiala Jeanselmei ◽

Renal Transplant Patients ◽

Subcutaneous Phaeohyphomycosis

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Trimmatostroma scutellare. [Descriptions of Fungi and Bacteria].

IMI Descriptions of Fungi and Bacteria ◽

10.1079/dfb/20073083192 ◽

2007 ◽

Author(s):

D. W. Minter

Keyword(s):

Czech Republic ◽

Geographical Distribution ◽

Pinus Contorta ◽

Conservation Status ◽

Larix Decidua ◽

Cladosporium Cladosporioides ◽

Diagnostic Features ◽

Juniperus Communis ◽

Cedrus Libani

Abstract Descriptions are given of Trimmatostroma scutellare, which are found on dead decaying branches, twigs and cones of conifers, including information on its geographical distribution (USA (California), Russia, Austria, Bulgaria, Czech Republic, UK, Iceland, Norther Ireland, Poland, Sweden, Switzerland and Ukraine), hosts (Abies sp., Cedrus libani, Juniperus communis, Larix decidua, L. europaea, L. kaempferi, L. komarovii, L. sibirica, Larix sp., Pinus contorta, P. maritima var. nigra, P. mugo, P. nigra, P. radiata, P. sibirica, P. sylvestris and Pinus sp.), other associated organisms (Cladosporium cladosporioides and Sclerophoma pithiophila [Sydowia polyspora]), diagnostic features, biology and conservation status.

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Subcutaneous Phaeohyphomycosis due to Alternaria dennisii in an Immunocompromised Patient

Acta Dermato Venereologica ◽

10.2340/00015555-2343 ◽

2016 ◽

Vol 96 (5) ◽

pp. 701-702 ◽

Cited By ~ 3

Author(s):

J Diernaes ◽

K Hjuler ◽

L Kristensen ◽

M Deleuran

Keyword(s):

Immunocompromised Patient ◽

Subcutaneous Phaeohyphomycosis

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