Dorsal root ganglion toll-like receptor 4 signaling contributes to oxaliplatin-induced peripheral neuropathy

Pain ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Amina M. Illias ◽  
Kai-Jie Yu ◽  
Seon-Hee Hwang ◽  
Jacob Solis ◽  
Hongmei Zhang ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Chemotherapy-Induced Peripheral Neuropathy Treated with Dorsal Root Ganglion Stimulation

Pain Medicine ◽  
2018 ◽  
Vol 20 (4) ◽  
pp. 857-859 ◽  
Author(s):  
Pauline S Groenen ◽  
Noud van Helmond ◽  
Kenneth B Chapman
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Dorsal Root

Global Transcriptomic Profile of Dorsal Root Ganglion and Physiological Correlates of Cisplatin-Induced Peripheral Neuropathy

2019 ◽  
Vol 68 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Sherrie Lessans ◽  
Cameron B. Lassiter ◽  
Valentina Carozzi ◽  
Patrick Heindel ◽  
Sara Semperboni ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Transcriptomic Profile

scholarly journals Studies on the changes ofc-fosprotein in spinal cord and neurotransmitter in dorsal root ganglion of the rat with an experimental peripheral neuropathy

2001 ◽  
Vol 42 (1) ◽  
pp. 30 ◽  
Author(s):  
Won Taek Lee ◽  
Min Kyun Sohn ◽  
Seung Hwa Park ◽  
Soo Kyung Ahn ◽  
Jong Eun Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Dorsal Root

scholarly journals Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons

Molecules ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 775
Author(s):  
Xingjuan Chen ◽  
Yaqian Duan ◽  
Ashley Riley ◽  
Megan Welch ◽  
Fletcher White ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Dorsal Root Ganglion ◽  
Patch Clamp ◽  
Dorsal Root ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Dorsal Root Ganglion Neurons ◽  
Transient Receptor Potential Vanilloid ◽  
Drg Neurons ◽  
Ganglion Neurons

Individuals with end-stage diabetic peripheral neuropathy present with decreased pain sensation. Transient receptor potential vanilloid type 1 (TRPV1) is implicated in pain signaling and resides on sensory dorsal root ganglion (DRG) neurons. We investigated the expression and functional activity of TRPV1 in DRG neurons of the Ins2+/Akita mouse at 9 months of diabetes using immunohistochemistry, live single cell calcium imaging, and whole-cell patch-clamp electrophysiology. 2′,7′-Dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescence assay was used to determine the level of Reactive Oxygen Species (ROS) in DRGs. Although TRPV1 expressing neuron percentage was increased in Ins2+/Akita DRGs at 9 months of diabetes compared to control, capsaicin-induced Ca2+ influx was smaller in isolated Ins2+/Akita DRG neurons, indicating impaired TRPV1 function. Consistently, capsaicin-induced Ca2+ influx was decreased in control DRG neurons cultured in the presence of 25 mM glucose for seven days versus those cultured with 5.5 mM glucose. The high glucose environment increased cytoplasmic ROS accumulation in cultured DRG neurons. Patch-clamp recordings revealed that capsaicin-activated currents decayed faster in isolated Ins2+/Akita DRG neurons as compared to those in control neurons. We propose that in poorly controlled diabetes, the accelerated rate of capsaicin-sensitive TRPV1 current decay in DRG neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy.

scholarly journals Toll-Like Receptor 4 Signaling Contributes to Paclitaxel-Induced Peripheral Neuropathy

2014 ◽  
Vol 15 (7) ◽  
pp. 712-725 ◽  
Author(s):  
Yan Li ◽  
Haijun Zhang ◽  
Hongmei Zhang ◽  
Alyssa K. Kosturakis ◽  
Abdul Basit Jawad ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4
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