Multiple Myeloma With Isolated Plasmacytoma in Temporal Bone

AbstractThe manifestations of multiple myeloma are protean and related to bony osteolytic lesions, and to medullar and renal insufficiency. We report a patient who presented with otalgia as the inaugural symptom of multiple myeloma. Local irradiation combined with systemic chemotherapy led to the disappearance of the temporal bone mass and the accompanying symptoms. To date, 24 months after the diagnosis, the patient is still in remission.The literature on otological involvement in multiple myeloma is reviewed. Symptoms are non-specific and include hearing loss, tinnitus, dizziness, facial paralysis, and otalgia. The diagnosis of multiple myeloma should be considered in the presence of a temporal bone mass.

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Otologic presentation of multiple myeloma with isolated temporal bone involvement: Diagnostic and therapeutic implications

Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery ◽

10.4103/aiao.aiao_25_18 ◽

2019 ◽

Vol 3 (1) ◽

pp. 45

Author(s):

JG Aishwarya ◽

Satish Nair ◽

Parameswaran Anoop ◽

Swarna Shivakumar ◽

ArunaR Patil ◽

...

Keyword(s):

Multiple Myeloma ◽

Temporal Bone ◽

Bone Involvement ◽

Therapeutic Implications

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Temporal Bone Involvement in Multiple Myeloma

Otology & Neurotology ◽

10.1097/01.mao.0000188349.44430.59 ◽

2006 ◽

Vol 27 (4) ◽

pp. 580-581

Author(s):

Boris G. Naraev ◽

Fred H. Linthicum

Keyword(s):

Multiple Myeloma ◽

Temporal Bone ◽

Bone Involvement

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Bisphosphonate-associated osteonecrosis of the external auditory canal

The Journal of Laryngology & Otology ◽

10.1017/s002221511300100x ◽

2013 ◽

Vol 127 (S2) ◽

pp. S51-S53 ◽

Cited By ~ 12

Author(s):

N Wickham ◽

A Crawford ◽

A S Carney ◽

A N Goss

Keyword(s):

Multiple Myeloma ◽

Temporal Bone ◽

External Auditory Canal ◽

Case Reports ◽

Bone Lesion ◽

Benign Condition ◽

Exposed Bone ◽

Drug History ◽

History Of ◽

The Right

AbstractBackground:Osteonecrosis is a benign condition characterised by necrotic exposed bone, and is associated with bisphosphonate use. Osteonecrosis of the external auditory canal is rare, with only a few reported cases.Method:Two case reports of temporal bone osteonecrosis are presented.Results:A 64-year-old man with a history of immunoglobulin G kappa multiple myeloma developed a right external auditory canal ulcer 6 years after commencement on clodronate. A 72-year-old woman taking alendronate for osteoporosis, initially diagnosed and treated for right-sided otitis externa, was found to have underlying exposed bone in the right external auditory canal, with a computed tomography scan confirming destruction of the temporal bone.Conclusion:With increasing use of both oral and intravenous bisphosphonates in the community for benign conditions such as osteoporosis and for malignant conditions such as breast cancer and multiple myeloma, the diagnosis of bisphosphonate-associated osteonecrosis should always be considered in patients with a temporal bone lesion, and a relevant drug history taken.

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