High-Grade Transformation (“Dedifferentiation”)—Malignant Progression of Salivary Gland Neoplasms, Including Carcinoma ex Pleomorphic Adenoma

2015 ◽  
Vol 20 (1) ◽  
pp. 27-37 ◽  
Author(s):  
Fredrik Petersson
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Neoplasms ◽  
Malignant Progression ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
High Grade ◽  
High Grade Transformation

scholarly journals Ki-67 Index in Salivary Gland Neoplasms

2016 ◽  
Vol 6 (1) ◽  
pp. 1-7
Author(s):  
Suma Kaza ◽  
T Jaya Mastan Rao ◽  
Anupama Mikkilineni ◽  
G Venkata Ratnam ◽  
D Ranga Rao
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Mucoepidermoid Carcinoma ◽  
Salivary Gland Neoplasms ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Myoepithelial Carcinoma ◽  
Cell Adenoma ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Epithelial Myoepithelial Carcinoma

Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

scholarly journals Eternal dilemma of the interplay between coexisting tuberculosis and malignancy: Clinical scenario of coexisting submandibular carcinoma with disseminated tuberculosis: A case report

2016 ◽  
Vol 7 (3) ◽  
pp. 115-117
Author(s):  
Manjari Shah ◽  
Nitin Leekha ◽  
Sweety Gupta ◽  
S Sowmiya ◽  
Garima Garg ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Extrapulmonary Tuberculosis ◽  
Salivary Gland Neoplasms ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Clinical Scenario ◽  
Medical Sciences ◽  
Common Site ◽  
Submandibular Region ◽  
Generalized Lymphadenopathy

Tuberculosis (TB) and malignancy are two lethal diseases that cause significant morbidity and mortality in developing countries like India. Extrapulmonary tuberculosis (TB) constitutes about 15 to 20 per cent of all cases of tuberculosis with lymph nodes being the most common site of involvement.1 Malignant transformation in pleomorphic adenoma lead to carcinoma ex pleomorphic adenoma (CXPA). CXPA of the salivary glands, however, is relatively uncommon, accounting for 3.6 % of all salivary gland neoplasms and 11.7 % of all malignant salivary gland neoplasms.2 Here we report a case of carcinoma ex pleomorphic adenoma of submandibular gland which presented as a swelling in submandibular region along with generalized lymphadenopathy which mimicked widespread metastases but later on histologically showed tuberculosis. Asian Journal of Medical Sciences Vol. 7(3) 2016 115-117

scholarly journals Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

2021 ◽  
Author(s):  
Costantino Ricci ◽  
Federico Chiarucci ◽  
Francesca Ambrosi ◽  
Tiziana Balbi ◽  
Barbara Corti ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Pleomorphic Adenoma ◽  
Salivary Gland Tumors ◽  
Melanin Pigment ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Pertinent Literature

AbstractThe presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon.

Cytologic and Histologic Aspects of High-Grade Transformation of Salivary Gland Carcinoma

2020 ◽  
Vol 25 (5) ◽  
pp. 243-248
Author(s):  
Masato Nakaguro ◽  
William C. Faquin ◽  
Peter M. Sadow
Keyword(s):  
Salivary Gland ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Gland Carcinoma ◽  
High Grade Transformation

Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland

Pathology ◽  
2009 ◽  
Vol 41 (7) ◽  
pp. 634-639 ◽  
Author(s):  
Yoriko Nakajima ◽  
Takashi Kishimoto ◽  
Yuichiro Nagai ◽  
Masatoshi Yamada ◽  
Yumiko Iida ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Androgen Receptor ◽  
Pleomorphic Adenoma ◽  
Carcinoma Ex Pleomorphic Adenoma

Malignant transformation of the salivary gland pleomorphic adenoma in myoepithelial carcinoma – the report of two cases

2019 ◽  
Vol 8 (1) ◽  
pp. 52-55
Author(s):  
Paulina Szabelska ◽  
Anna Rzepakowska ◽  
Benedykt Szczepankiewicz ◽  
Elżbieta Niemczyk ◽  
Ewa Osuch-Wójcikiewicz ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Surgical Treatment ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Malignant Transformation ◽  
Benign Tumor ◽  
Complete Recovery ◽  
Surrounding Tissue ◽  
Carcinoma Ex Pleomorphic Adenoma ◽  
Myoepithelial Carcinoma

A multiform adenoma is the most commonly diagnosed benign tumor of the salivary glands. In the majority of patients, surgical resection of the tumor with the adequate surrounding tissue of salivary gland allows for complete recovery. A small percentage of the cases is a recurring pleomorphic adenoma. Even more rarely the diagnosis of carcinoma ex pleomorphic adenoma is made. The study presents two clinical cases of the malignant transformation of pleomorphic adenoma into the myoepithelial carcinoma. The surgical treatment and additional radiotherapy were performed in both cases.

Sign in / Sign up

Export Citation Format

Share Document