scholarly journals Expanding the clinicopathological spectrum of TGFBR3‐PLAG1 rearranged salivary gland neoplasms with myoepithelial differentiation including evidence of high‐grade transformation

2021 ◽  
Author(s):  
Niels. J. Rupp ◽  
Sylvia Höller ◽  
Muriel Brada ◽  
Domenic Vital ◽  
Grégoire B. Morand ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Neoplasms ◽  
High Grade ◽  
Myoepithelial Differentiation ◽  
High Grade Transformation

Cytologic and Histologic Aspects of High-Grade Transformation of Salivary Gland Carcinoma

2020 ◽  
Vol 25 (5) ◽  
pp. 243-248
Author(s):  
Masato Nakaguro ◽  
William C. Faquin ◽  
Peter M. Sadow
Keyword(s):  
Salivary Gland ◽  
High Grade ◽  
Salivary Gland Carcinoma ◽  
Gland Carcinoma ◽  
High Grade Transformation

scholarly journals Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2433
Author(s):  
David Y. Lee ◽  
Kathryn J. Brayer ◽  
Yoshitsugu Mitani ◽  
Eric A. Burns ◽  
Pulivarthi H. Rao ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Binding Domain ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Orphan Nuclear Receptor ◽  
Acinic Cell ◽  
High Grade Transformation ◽  
Domain Transformation

Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little is known about how NR4A3 contributes to AcCC biology. Detailed RNA-sequencing of 21 archived AcCC samples revealed fusion reads arising from recurrent t(4;9), t(9;12), t(8;9) or t(2;4) chromosomal translocations, which positioned highly active enhancers adjacent to the promoter of the NR4A3 gene or the closely related NR4A2 gene, resulting in their aberrant overexpression. Transcriptome analyses revealed several distinct subgroups of AcCC tumors, including a subgroup that overexpressed both NR4A3 and MSANTD3. A poor survival subset of the tumors with high-grade transformation expressed NR4A3 and POMC as well as MYB, an oncogene that is the major driver in a different type of salivary gland tumor, adenoid cystic carcinoma. The combination of NR4A3 and MYB showed cooperativity in regulating a distinct set of genes. In addition, the ligand binding domain of NR4A3 directly bound the Myb DNA binding domain. Transformation assays indicated that, while overexpressed NR4A3 was sufficient to generate transformed colonies, the combination of NR4A3 plus Myb was more potent, leading to anchorage-independent growth and increased cellular invasiveness. The results confirm that NR4A3 and NR4A2 are the main driver genes of AcCC and suggest that concurrent overexpression of NR4A3 and MYB defines a subset of AcCC patients with high-grade transformation that display exceptionally poor outcome.

Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

2016 ◽  
Vol 469 (6) ◽  
pp. 643-650 ◽  
Author(s):  
Henrik Hellquist ◽  
Alena Skalova ◽  
Bahram Azadeh
Keyword(s):  
Salivary Gland ◽  
Low Grade ◽  
High Grade ◽  
High Grade Transformation ◽  
Hybrid Tumour

Salivary Gland Epithelial–Myoepithelial Carcinoma with High-Grade Transformation in a Dog

2015 ◽  
Vol 153 (2-3) ◽  
pp. 111-115 ◽  
Author(s):  
T.E. Kishimoto ◽  
H. Yoshimura ◽  
N. Saito ◽  
M. Michishita ◽  
N. Kanno ◽  
...  
Keyword(s):  
Salivary Gland ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
High Grade Transformation ◽  
Epithelial Myoepithelial Carcinoma

scholarly journals Exploration of High-Grade Transformation and Postoperative Radiotherapy on Prognostic Analysis for Primary Adenoid Cystic Carcinoma of the Head and Neck

2021 ◽  
Vol 11 ◽  
Author(s):  
Yuelu Zhu ◽  
Xinyi Zhu ◽  
Xuemin Xue ◽  
Ye Zhang ◽  
Chunfang Hu ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Postoperative Radiotherapy ◽  
High Grade ◽  
Tumor Grading ◽  
Prognostic Analysis ◽  
Adenoid Cystic ◽  
Myoepithelial Differentiation ◽  
High Grade Transformation ◽  
Grade Iii

BackgroundDespite Adenoid cystic carcinoma (ACC) with cribriform or tubular components being recognized as a potentially indolent malignancy, ACC displaying solid or, more rarely, high-grade transformation (HGT) components is considered a more aggressive variant of the disease. As it is difficult to measure the proportion of the solid component objectively, and the role of HGT in the current grading system remains unclear, the prognostic influence of tumor grading remains controversial. In addition, postoperative radiotherapy (PORT) has been proven to be effective in local control of ACC of the head and neck (ACCHN) with a high rate of nerve invasion and close surgical margin. However it remains to be explored that whether PORT could improve the survival of patients with ACC, particularly those with HGT.MethodsA series of 73 surgically treated primary ACCHN cases were retrospectively accessed. Immunohistochemical staining was performed to observe the biphasic ductal-myoepithelial differentiation and to identify the HGT components of ACC for tumor grading. The correlation between tumor grading and clinicopathological characteristics was analyzed. Univariate and multivariate prognostic analysis were performed for progression-free survival (PFS) and overall survival (OS).ResultsOf the 73 included cases, 47 were grade I-II ACC and 26 were grade III ACC. Among the grade III cases, 14 with loss of biphasic ductal-myoepithelial differentiation identified by immunostaining were classified as HGT, and could be distinguished from conventional grade III cases. These HGT cases were correlated with a high propensity of lymph node metastases and more advanced stage. Univariate analysis demonstrated that tumor grading, perineural invasion, T stage, stage groups, and PORT were predictors for PFS, whereas tumor grading, margin status, and PORT were predictors for OS. However, only tumor grading and PORT were independent predictors for PFS and OS. The patients with HGT had significantly worse prognosis than those with conventional ACC. Moreover, disease progression tended to occur more frequently in younger patients. Among the patients with HGT, those who received PORT had a longer median survival time than those who did not.ConclusionHGT ACC identified by loss of biphasic differentiation should be considered in tumor grading. Tumor grading and PORT were independent predictors for disease progression and OS in surgically treated ACCHN patients.

scholarly journals High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance

2021 ◽  
Vol 28 (3) ◽  
pp. 107-118
Author(s):  
Alena Skalova ◽  
Ilmo Leivo ◽  
Henrik Hellquist ◽  
Abbas Agaimy ◽  
Roderick H.W. Simpson ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Clinical Significance ◽  
High Grade ◽  
Salivary Gland Carcinomas ◽  
High Grade Transformation
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