Safety and Effectiveness of Autologous Fat Grafting after Breast Radiotherapy: A Systematic Review and Meta-Analysis

Due to the high absorption rate of traditional autologous fat grafting, cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer were developed. The purpose of this article was to evaluate the efficacy and safety of CAL and PRP in promoting the survival of autologous fat grafting through systematic review and meta-analysis. We searched Pubmed, Cochrane Library, Web of Science, and EMBASE for clinical studies on CAL and PRP-assisted lipotransfer published from January 2010 to January 2020. Then a meta-analysis was performed to assess the efficacy of CAL and PRP-assisted lipotransfer through data analysis of fat survival rate. We also assessed the incidence of complications and multiple operations to analyze their safety. A total of 36 studies (1697 patients) were included in this review. Regardless of the recipient area, CAL and PRP-assisted lipotransfer significantly improved the fat survival rate (CAL vs non-CAL: 71% vs 48%, P < 0.0001; PRP vs non-PRP: 70% vs 40%, P < 0.0001; CAL vs PRP: 71% vs 70%, P = 0.7175). However, in large-volume fat grafting, such as breast reconstruction, both increased the incidence of complications and did not decrease the frequency of multiple operations after lipotransfer. Further prospective studies are needed to evaluate the clinical benefits of CAL and PRP-assisted lipotransfer.

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Use of autologous fat grafting for reconstruction post-mastectomy and breast conserving surgery: A systematic review and meta-analysis of oncological outcomes

Journal of Plastic Reconstructive & Aesthetic Surgery ◽

10.1016/j.bjps.2014.08.027 ◽

2014 ◽

Vol 67 (10) ◽

pp. 1463-1464

Author(s):

Riaz A. Agha ◽

Alexander J. Fowler ◽

Christian Herlin ◽

Tim Goodacre ◽

Dennis P. Orgill

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Breast Conserving Surgery ◽

Fat Grafting ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Oncological Outcomes

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Efficacy, safety and complications of autologous fat grafting to the eyelids and periorbital area: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0248505 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0248505

Author(s):

Fan Yang ◽

Zhaohua Ji ◽

Liwei Peng ◽

Ting Fu ◽

Kun Liu ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Fat Grafting ◽

Cochrane Library ◽

Efficacy And Safety ◽

Autologous Fat Grafting ◽

Autologous Fat ◽

Satisfaction Rate ◽

High Satisfaction ◽

High Satisfaction Rate

Background In recent years, autologous fat grafting (AFG), also known as fat transfer or lipofilling, has been widely performed for periorbital rejuvenation and defect correction, although the evidence regarding its efficacy and safety is still lacking. Besides, with respect to the periorbital region, it is invariably the earliest appearance area of the facial aging phenomenon. Therefore, a systematic review and meta-analysis is needed to evaluate the efficacy and safety of this technique. Methods A literature search was performed in PubMed, Embase, and the Cochrane library databases on November 20, 2020, adhering to the PRISMA guidelines, to identify all relevant articles. Then, a data extraction and standardization process was performed to assess all outcome data. Ultimately, the data were assessed using a random effects regression model with comprehensive meta-analysis software. Results Thirty-nine studies consisting of 3 cohorts and 36 case series with a total of 4046 cases were included. Meta-analysis revealed a relatively high satisfaction rate of 90.9% (95% CI, 86.4%–94.0%). Frequent complications in 4046 patients receiving AFG were edema, chemosis, and contour irregularity, with an overall complication rate of 7.9% (95% CI, 4.8%–12.8%). Conclusion This systematic review and meta-analysis showed that AFG for rejuvenation of eyelids and periorbital area provided a high satisfaction rate and did not result in severe complications. Therefore, AFG might be performed safely for periorbital rejuvenation and reconstruction.

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