Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis

JCR Journal of Clinical Rheumatology ◽

10.1097/rhu.0000000000000810 ◽

2019 ◽

Vol 25 (5) ◽

pp. 197-202 ◽

Author(s):

Lijun Liu ◽

Shengyun Liu ◽

Cong Wang ◽

Wenjuan Guan ◽

Yinli Zhang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Methotrexate Therapy ◽

Folate Supplementation

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Gynecomastia in a Rheumatoid Arthritis patient: A rare side effect of Methotrexate therapy. (Preprint)

10.2196/preprints.6311 ◽

2016 ◽

Author(s):

Soorih Shaikh ◽

Sarwan Shaikh

Keyword(s):

Rheumatoid Arthritis ◽

Rheumatoid Arthritis Patient ◽

Male Patient ◽

Side Effect ◽

Methotrexate Therapy ◽

Folate Supplementation ◽

Rare Side Effect ◽

UNSTRUCTURED A 51-year-old male patient with a 3-year history of Rheumatoid Arthritis developed gynecomastia 2-3 months after starting Methotrexate therapy, without folate supplementation. Two months after stopping MTX therapy and initiating folate supplementation, gynecomastia started resolving. Very few cases of gynecomastia due to MTX therapy have been reported worldwide. Although it is a rare yet a significant occurrence and should always be considered in male patients with Rheumatoid Arthritis.

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Faculty Opinions recommendation of Induction therapy with adalimumab plus methotrexate for 24 weeks followed by methotrexate monotherapy up to week 48 versus methotrexate therapy alone for DMARD-naive patients with early rheumatoid arthritis: HIT HARD, an investigator-initiated study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717748061.793153315 ◽

2012 ◽

Author(s):

Ulf Müller-Ladner

Keyword(s):

Rheumatoid Arthritis ◽

Early Rheumatoid Arthritis ◽

Induction Therapy ◽

Methotrexate Therapy

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Faculty Opinions recommendation of Golimumab, a human antibody to tumour necrosis factor {alpha} given by monthly subcutaneous injections, in active rheumatoid arthritis despite methotrexate therapy: the GO-FORWARD Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718325310.793492804 ◽

2014 ◽

Author(s):

Ronald van Vollenhoven

Keyword(s):

Rheumatoid Arthritis ◽

Tumour Necrosis ◽

Active Rheumatoid Arthritis ◽

Tumour Necrosis Factor Alpha ◽

Methotrexate Therapy ◽

Human Antibody ◽

Necrosis Factor Alpha ◽

Subcutaneous Injections ◽

Factor Alpha ◽

Necrosis Factor

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THU0609 Patient-Reported Outcomes from A Phase 3 Study of Baricitinib versus Placebo or Adalimumab in Patients with Active Rheumatoid Arthritis and An Inadequate Response To Background Methotrexate Therapy: Table 1.

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.1239 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 412.2-413 ◽

Author(s):

E. Keystone ◽

P. Taylor ◽

Y. Tanaka ◽

C. Gaich ◽

A.M. DeLozier ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Patient Reported Outcomes ◽

Active Rheumatoid Arthritis ◽

Methotrexate Therapy ◽

Inadequate Response ◽

Phase 3 ◽

Patient Reported

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THU0138 Secondary Efficacy Results Up To Week 24 from A Phase III Study Comparing SB5 (An Adalimumab Biosimiar) with Adalimumab Reference Product in Patients with Moderate To Severe Rheumatoid Arthritis despite Methotrexate Therapy

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.2021 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 231.1-231

Author(s):

J. Kay ◽

M. Weinblatt ◽

E. Keystone ◽

M.C. Genovese ◽

A. Baranauskaite ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Reference Product ◽

Methotrexate Therapy ◽

Phase Iii ◽

Severe Rheumatoid Arthritis ◽

Phase Iii Study

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Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis

Modern Rheumatology ◽

10.3109/s10165-006-0522-2 ◽

2006 ◽

Vol 16 (6) ◽

pp. 401-403 ◽

Author(s):

Isao Matsushita ◽

Miwa Uzuki ◽

Hiroaki Matsuno ◽

Eiji Sugiyama ◽

Tomoastu Kimura

Keyword(s):

Rheumatoid Arthritis ◽

Methotrexate Therapy ◽

Rheumatoid Nodulosis

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Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis

Arthritis & Rheumatism ◽

10.1002/art.1780311202 ◽

1988 ◽

Vol 31 (12) ◽

pp. 1465-1472 ◽

Author(s):

David J. Bjorkman ◽

Elizabeth H. Hammond ◽

Randall G. Lee ◽

Daniel O. Clegg ◽

Keith G. Tolman

Keyword(s):

Rheumatoid Arthritis ◽

Methotrexate Therapy

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The effects of golimumab on radiographic progression in rheumatoid arthritis: Results of randomized controlled studies of golimumab before methotrexate therapy and golimumab after methotrexate therapy

Arthritis & Rheumatism ◽

10.1002/art.30263 ◽

2011 ◽

Vol 63 (5) ◽

pp. 1200-1210 ◽

Author(s):

Paul Emery ◽

Roy Fleischmann ◽

Désirée van der Heijde ◽

Edward C. Keystone ◽

Mark C. Genovese ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Radiographic Progression ◽

Methotrexate Therapy ◽

Randomized Controlled ◽

Randomized Controlled Studies

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Efficacy and safety results from a Phase 3, randomized, placebo-controlled trial of subcutaneous golimumab in Chinese patients with active rheumatoid arthritis despite methotrexate therapy

International Journal of Rheumatic Diseases ◽

10.1111/1756-185x.12723 ◽

2015 ◽

Vol 19 (11) ◽

pp. 1143-1156 ◽

Author(s):

Zhanguo Li ◽

Fengchun Zhang ◽

Jonathan Kay ◽

Kaiyin Fei ◽

Chenglong Han ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Active Rheumatoid Arthritis ◽

Controlled Trial ◽

Methotrexate Therapy ◽

Chinese Patients ◽

Efficacy And Safety ◽

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Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS)

Arthritis Research & Therapy ◽

10.1186/s13075-018-1645-5 ◽

2018 ◽

Vol 20 (1) ◽

Author(s):

Jamie C. Sergeant ◽

◽

Kimme L. Hyrich ◽

James Anderson ◽

Kamilla Kopec-Harding ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Methotrexate Therapy ◽

Psychosocial Variables ◽

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