Spontaneous Recovery of Reduced Cortical Central Benzodiazepine Receptor Binding Potential on I-123 Iomazenil SPECT in a Patient With Status Epilepticus

2010 ◽  
Vol 35 (2) ◽  
pp. 126-127 ◽  
Author(s):  
Hiroki Kuroda ◽  
Kuniaki Ogasawara ◽  
Kenta Aso ◽  
Takaaki Beppu ◽  
Masakazu Kobayashi ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Receptor Binding ◽  
Spontaneous Recovery ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Central Benzodiazepine Receptor

Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECT

1993 ◽  
Vol 14 (8) ◽  
pp. 634-643 ◽  
Author(s):  
N. P.L.G. VERHOEFF ◽  
B. ERBAS ◽  
O. KAPUCU ◽  
E. BUSEMANN SOKOLE ◽  
H. BLOK ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Central Benzodiazepine Receptor ◽  
The Brain

scholarly journals Chronological Changes in Brain Blood Flow and Central Benzodiazepine Receptor Binding Potential in a Patient with Symptomatic Epilepsy after Surgery for Aneurysmal Subarachnoid Hemorrhage: 123I-Iomazenil Single-Photon Emission Computed Tomography Studies

2017 ◽  
Vol 9 (3) ◽  
pp. 222-227
Author(s):  
Toshiyuki Murakami ◽  
Hiroshi Kashimura ◽  
Hidehiko Endo ◽  
Hiroki Kuroda ◽  
Kuniaki Ogasawara
Keyword(s):  
Receptor Binding ◽  
Single Photon ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Photon Emission ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Emission Computed Tomography ◽  
Symptomatic Epilepsy ◽  
Central Benzodiazepine Receptor ◽  
Photon Emission Computed Tomography

Early 123I-iomazenil single-photon emission computed tomography (SPECT) images are correlated with blood flow in the brain, and late images are correlated with cortical benzodiazepine receptor binding potential. Reduced metabolism in the contralateral cerebral hemisphere is indicated by crossed cerebellar hypoperfusion (CCH). We present the case of a 63-year-old man who developed symptomatic epilepsy 13 days after surgery for an aneurysmal subarachnoid hemorrhage. Early images on 123I-iomazenil SPECT 2 days after seizure onset revealed CCH and hyperperfusion in the affected cerebral hemisphere where benzodiazepine receptor binding potential was reduced in late images on 123I-iomazenil SPECT. These abnormal findings resolved on repeated 123I-iomazenil SPECT 1 month after seizure onset. The case we present here is consistent with the idea that the central benzodiazepine receptor system in the human brain undergoes changes that are related to seizures due to epilepsy.

In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy

Neurology ◽  
1993 ◽  
Vol 43 (10) ◽  
pp. 1998-1998 ◽  
Author(s):  
T. R. Henry ◽  
K. A. Frey ◽  
J. C. Sackellares ◽  
S. Gilman ◽  
R. A. Koeppe ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Receptor Binding ◽  
Cerebral Metabolism ◽  
Benzodiazepine Receptor ◽  
Central Benzodiazepine Receptor
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