Asymmetries of benzodiazepine receptor binding potential in the inferior medial temporal lobe and cerebellum detected with123I-iomazenil SPECT in comparison with99mTc-HMPAO SPECT in patients with partial epilepsy

1998 ◽  
Vol 12 (4) ◽  
pp. 185-190 ◽  
Author(s):  
Ichiei Kuji ◽  
Hisashi Sumiya ◽  
Shiro Tsuji ◽  
Akihiro Ichikawa ◽  
Norihisa Tonami
Keyword(s):  
Temporal Lobe ◽  
Receptor Binding ◽  
Medial Temporal Lobe ◽  
Benzodiazepine Receptor ◽  
Partial Epilepsy ◽  
Binding Potential ◽  
Hmpao Spect

Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

Quantification of central benzodiazepine receptor binding potential in the brain with 123I-iomazenil SPECT

1993 ◽  
Vol 14 (8) ◽  
pp. 634-643 ◽  
Author(s):  
N. P.L.G. VERHOEFF ◽  
B. ERBAS ◽  
O. KAPUCU ◽  
E. BUSEMANN SOKOLE ◽  
H. BLOK ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Central Benzodiazepine Receptor ◽  
The Brain

scholarly journals Chronological Changes in Brain Blood Flow and Central Benzodiazepine Receptor Binding Potential in a Patient with Symptomatic Epilepsy after Surgery for Aneurysmal Subarachnoid Hemorrhage: 123I-Iomazenil Single-Photon Emission Computed Tomography Studies

2017 ◽  
Vol 9 (3) ◽  
pp. 222-227
Author(s):  
Toshiyuki Murakami ◽  
Hiroshi Kashimura ◽  
Hidehiko Endo ◽  
Hiroki Kuroda ◽  
Kuniaki Ogasawara
Keyword(s):  
Receptor Binding ◽  
Single Photon ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Photon Emission ◽  
Benzodiazepine Receptor ◽  
Binding Potential ◽  
Emission Computed Tomography ◽  
Symptomatic Epilepsy ◽  
Central Benzodiazepine Receptor ◽  
Photon Emission Computed Tomography

Early 123I-iomazenil single-photon emission computed tomography (SPECT) images are correlated with blood flow in the brain, and late images are correlated with cortical benzodiazepine receptor binding potential. Reduced metabolism in the contralateral cerebral hemisphere is indicated by crossed cerebellar hypoperfusion (CCH). We present the case of a 63-year-old man who developed symptomatic epilepsy 13 days after surgery for an aneurysmal subarachnoid hemorrhage. Early images on 123I-iomazenil SPECT 2 days after seizure onset revealed CCH and hyperperfusion in the affected cerebral hemisphere where benzodiazepine receptor binding potential was reduced in late images on 123I-iomazenil SPECT. These abnormal findings resolved on repeated 123I-iomazenil SPECT 1 month after seizure onset. The case we present here is consistent with the idea that the central benzodiazepine receptor system in the human brain undergoes changes that are related to seizures due to epilepsy.

Cortical Benzodiazepine Receptor Binding in Patients with Generalized and Partial Epilepsy

Epilepsia ◽  
1990 ◽  
Vol 31 (6) ◽  
pp. 724-730 ◽  
Author(s):  
Ivanka Savic ◽  
Lennart Widen ◽  
Jan Olof Thorell ◽  
Gunnar Blomqvist ◽  
Kaj Ericson ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Benzodiazepine Receptor ◽  
Partial Epilepsy

scholarly journals [11C]Flumazenil PET in Temporal Lobe Epilepsy: Do We Need an Arterial Input Function or Kinetic Modeling?

2007 ◽  
Vol 28 (1) ◽  
pp. 207-216 ◽  
Author(s):  
Alexander Hammers ◽  
Prasan Panagoda ◽  
Rolf A Heckemann ◽  
Wolfgang Kelsch ◽  
Federico E Turkheimer ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Arterial Input Function ◽  
Diagnostic Yield ◽  
Hippocampal Sclerosis ◽  
Input Function ◽  
Binding Potential ◽  
Reference Tissue ◽  
Arterial Plasma

Reduced signal on [11C]]flumazenil (FMZ) positron emission tomography (PET) is associated with epileptogenic foci. Linear correlations within individuals between parametric and nonparametric images of FMZ binding have been shown, and various methods have been used, without comparison of diagnostic usefulness. Using hippocampal sclerosis (HS) as a test case, we formally compare the diagnostic yield of parametric images obtained either with a parent tracer arterial plasma input function and spectral analysis (yielding volume-of-distribution (VD) images), or with an image-based input function and the simplified reference tissue model (binding potential images, BP-SRTM) with the diagnostic yield of semiquantitative-integrated (ADD) images from 10 to 20 or 20 to 40 mins (ADD1020 and ADD2040). Dynamic 90-min [11C]FMZ PET datasets and arterial plasma input functions were available for 15 patients with medically refractory medial temporal lobe epilepsy (TLE) and histologically verified unilateral HS and for 13 control subjects. SPM2 was used for analysis. ADD1020 and ADD2040 images showed decreased FMZ uptake ipsilateral to the epileptogenic hippocampus in 13/15 cases; 6/13 had bilateral decreases in the ADD1020 analysis and 5/13 in the ADD2040 analysis. BP-SRTM images detected ipsilateral decreases in 12/15 cases, with bilateral decreases in three. In contrast, VD images showed ipsilateral hippocampal decreases in all 15 patients, with bilateral decreases in three patients. Bilateral decreases in the ADD images tended to be more symmetrical and in one case were more marked contralaterally. Full quantification with an image-independent input should ideally be used in the evaluation of FMZ PET; at least in TLE, intrasubject correlations do not predict equivalent clinical usefulness.

In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy

Neurology ◽  
1993 ◽  
Vol 43 (10) ◽  
pp. 1998-1998 ◽  
Author(s):  
T. R. Henry ◽  
K. A. Frey ◽  
J. C. Sackellares ◽  
S. Gilman ◽  
R. A. Koeppe ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Receptor Binding ◽  
Cerebral Metabolism ◽  
Benzodiazepine Receptor ◽  
Central Benzodiazepine Receptor
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