Mesenteric Lymph Return Is an Important Contributor to Vascular Hyporeactivity and Calcium Desensitization After Hemorrhagic Shock

Shock ◽  
2012 ◽  
Vol 38 (2) ◽  
pp. 186-195 ◽  
Author(s):  
Zi-Gang Zhao ◽  
Chun-Yu Niu ◽  
Yan-Ling Wei ◽  
Yu-Ping Zhang ◽  
Yong-Hua Si ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Important Contributor ◽  
Mesenteric Lymph ◽  
Calcium Desensitization ◽  
Vascular Hyporeactivity

scholarly journals Autophagy Is Involved in Stellate Ganglion Block Reversing Posthemorrhagic Shock Mesenteric Lymph-Mediated Vascular Hyporeactivity

2021 ◽  
Vol 12 ◽  
Author(s):  
Chen Wang ◽  
Hui-Bo Du ◽  
Zhen-Ao Zhao ◽  
Jia-Yi Zhai ◽  
Li-Min Zhang ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Vascular Reactivity ◽  
Stellate Ganglion ◽  
Stellate Ganglion Block ◽  
Mesenteric Arteries ◽  
Cellular Viability ◽  
Ganglion Block ◽  
Mesenteric Lymph ◽  
Vascular Hyporeactivity

Objective: The aim of this study was to clarify the role of autophagy in stellate ganglion block (SGB) reversing posthemorrhagic shock mesenteric lymph (PHSML)-mediated vascular hyporeactivity.Methods: Hemorrhagic shock model in conscious rats was employed to observe the effects of SGB (0.2 ml of 0.25% ropivacaine hydrochloride hydrate) and autophagy inhibitor 3-methyladenine (3-MA; 30 mg/kg) on the vascular reactivity of second-order rat mesenteric arteries in vitro, while the effects of PHSML (1 ml/kg) and autophagy agonist rapamycin (Rapa, 10 mg/kg) on the beneficial effect of SGB were investigated. The cellular viability, contractility, and autophagy-related protein expressions in vascular smooth muscle cells (VSMCs) were detected following treatments of PHSML, PHSML obtained from the rats that underwent hemorrhagic shock plus SGB (PHSML-SGB), and PHSML plus 3-MA (5 mM), respectively.Results: Hemorrhagic shock significantly decreased the vascular reactivity to gradient norepinephrine (NE), which is reversed by the SGB treatment and 3-MA administration. On the contrary, PHSML intravenous infusion and Rapa administration inhibited the vascular contractile responses in rats that underwent hemorrhagic shock plus SGB treatment. PHSML treatment significantly inhibited the cellular viability and contractility in VSMCs, increased the expressions of LC3-II and Beclin 1, and decreased the expression of p62, along with opposite appearances in these indices following PHSML-SGB treatment. In addition, 3-MA counteracted the adverse roles of PHSML in these indices in VSMCs.Conclusion: SGB inhibits PHSML-mediated vascular hyporeactivity by reducing the excessive autophagy in VSMCs.

S-nitroso-N-acetylpenicillamine (SNAP) During Hemorrhagic Shock Improves Mortality as a Result of Recovery From Vascular Hyporeactivity

2000 ◽  
Vol 90 (2) ◽  
pp. 362 ◽  
Author(s):  
Shigehito Sato ◽  
Akira Suzuki ◽  
Yoshiki Nakajima ◽  
Tatsuaki Iwamoto ◽  
Hiromichi Bito ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Vascular Hyporeactivity

scholarly journals Mesenteric Lymph Duct Ligation Provides Long Term Protection Against Hemorrhagic Shock-induced Lung Injury

Shock ◽  
2000 ◽  
Vol 13 (5) ◽  
pp. 10A-11A ◽  
Author(s):  
J Sambol ◽  
D Xu ◽  
C Adams ◽  
E Deitch
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Mesenteric Lymph ◽  
Duct Ligation ◽  
Lymph Duct

The Effect of Liposome-Encapsulated Hemoglobin on Mediators in the Mesenteric Lymph Following Hemorrhagic Shock

2004 ◽  
Vol 15 (11) ◽  
pp. 579-586
Author(s):  
Toshiyuki Kakinuma ◽  
Junichi Aiboshi ◽  
Kaoru Koike ◽  
Kengo Onodera ◽  
Shigeki Kushimoto ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Mesenteric Lymph

Changes in Renal Tissue Proteome Induced by Mesenteric Lymph Drainage in Rats After Hemorrhagic Shock With Resuscitation

Shock ◽  
2014 ◽  
Vol 42 (4) ◽  
pp. 350-355 ◽  
Author(s):  
Zi-Gang Zhao ◽  
Li-Min Zhang ◽  
Yong-Zhuang Lv ◽  
Yong-Hua Si ◽  
Chun-Yu Niu ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Renal Tissue ◽  
Lymph Drainage ◽  
Mesenteric Lymph ◽  
Tissue Proteome

Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells

Surgery ◽  
2001 ◽  
Vol 129 (3) ◽  
pp. 351-363 ◽  
Author(s):  
Charles A. Adams ◽  
Da-Zhong Xu ◽  
Qi Lu ◽  
Edwin A. Deitch
Keyword(s):  
Endothelial Cells ◽  
Hemorrhagic Shock ◽  
Mesenteric Lymph
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