Hypothermic Oxygenated Liver Perfusion (HOPE) Prevents Tumor Recurrence in Liver Transplantation From Donation After Circulatory Death

2020 ◽  
Vol 272 (5) ◽  
pp. 759-765
Author(s):  
Matteo Mueller ◽  
Marit Kalisvaart ◽  
Joanne O‘Rourke ◽  
Shishir Shetty ◽  
Alessandro Parente ◽  
...  
2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Roberta Angelico ◽  
M. Thamara P. R. Perera ◽  
Tommaso Maria Manzia ◽  
Alessandro Parente ◽  
Chiara Grimaldi ◽  
...  

Efforts have been made by the transplant community to expand the deceased donor pool in paediatric liver transplantation (LT). The growing experience on donation after circulatory death (DCD) for adult LT has encouraged its use also in children, albeit in selective cases, opening new perspectives for paediatric patients. Even though there has recently been a slight increase in the number of DCD livers transplanted in children, with satisfactory graft and patient outcomes, the use of DCD grafts in paediatric recipients is still controversial due to morbid outcomes associated with DCD grafts. In this context, recent advances in the optimization of donor support by extracorporeal membrane oxygenation and in the graft preservation by liver machine perfusion could find application in order to expand the donor pool in paediatric LT. In the present study we review the current literature on DCD liver grafts transplanted in children and on the use of extracorporeal donor support and liver perfusion machines in paediatrics, with the aim of defining the current status and future perspectives of paediatric LT.


2020 ◽  
Vol 86 (2) ◽  
Author(s):  
Chiara Lazzeri ◽  
Manuela Bonizzoli ◽  
Fabio Marra ◽  
Paolo Muiesan ◽  
Davide Ghinolfi ◽  
...  

JAMA Surgery ◽  
2014 ◽  
Vol 149 (1) ◽  
pp. 77 ◽  
Author(s):  
Johnny C. Hong ◽  
Robert Venick ◽  
Hasan Yersiz ◽  
Prawat Kositamongkol ◽  
Fady M. Kaldas ◽  
...  

2018 ◽  
Vol 22 (2) ◽  
pp. 229-236 ◽  
Author(s):  
James M. West

Anesthesiologists have clearly established their place in the history of medical ethics. Our involvement goes back to 1966 when Henri Beecher published his landmark paper on research and informed consent. Participation in the ethics of transplantation is no less important than our previous work. Organ transplant has been life saving for many but also has given rise to many misunderstandings not just from the public but also among our own colleagues. These include methods of allocation and donation, the role that affluence may play in receiving an organ, the definition of death and donation after circulatory death. As perioperative physicians and important members of the transplant team, anesthesiologists are expected to participate in all aspects of care including ethical judgments. This article discusses some of the issues that seem to cause the most confusion and angst for those of us involved in both liver transplantation and in the procurement of organs. It will discuss the definition of death, donation after circulatory death, the anesthesiologists’ role on the selection committee, living donor liver transplantation, and transplantation of patients with alcohol-related liver disease.


2020 ◽  
Vol 40 (03) ◽  
pp. 256-263
Author(s):  
Kristopher P. Croome

AbstractDonation after circulatory death (DCD) donors represent a potential means to help address the disparity between the number of patients awaiting liver transplantation (LT) and the availability of donor livers. While initial enthusiasm for DCD LT was high in the early 2000s, early reports of high rates of biliary complications and inferior graft survival resulted in reluctance among many transplant centers to use DCD liver grafts. As with all innovations in transplant practice, there is undoubtedly a learning curve associated with the optimal utilization of liver grafts from DCD donors. More contemporary data has demonstrated that results with DCD LT are improving and the number of DCD LT performed annually has been steadily increasing. In this concise review, potential mechanisms of injury for DCD livers are discussed along with strategies that have been employed in clinical practice to improve DCD LT outcomes.


2018 ◽  
Vol 24 (8) ◽  
pp. 1001-1010 ◽  
Author(s):  
Marit Kalisvaart ◽  
Jubi E. de Haan ◽  
Wojciech G. Polak ◽  
Jan N. M. IJzermans ◽  
Diederik Gommers ◽  
...  

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