Whole Blood Hemostatic Resuscitation in Pediatric Trauma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Tanya Anand ◽  
Omar Obaid ◽  
Adam Nelson ◽  
Mohamad Chehab ◽  
Michael Ditillo ◽  
...  
Keyword(s):  
Whole Blood ◽  
Pediatric Trauma ◽  
Hemostatic Resuscitation

scholarly journals Lessons Learned From the Battlefield and Applicability to Veterinary Medicine – Part 2: Transfusion Advances

2021 ◽  
Vol 8 ◽  
Author(s):  
Thomas H. Edwards ◽  
Anthony E. Pusateri ◽  
Erin Long Mays ◽  
James A. Bynum ◽  
Andrew P. Cap
Keyword(s):  
Trauma Care ◽  
Whole Blood ◽  
Military Medicine ◽  
Severe Trauma ◽  
Lessons Learned ◽  
Ease Of Use ◽  
Blood Components ◽  
Hemostatic Resuscitation ◽  
Primary Means ◽  
Traumatic Hemorrhagic Shock

Since the inception of recent conflicts in Afghanistan and Iraq, transfusion practices in human military medicine have advanced considerably. Today, US military physicians recognize the need to replace the functionality of lost blood in traumatic hemorrhagic shock and whole blood is now the trauma resuscitation product of choice on the battlefield. Building on wartime experiences, military medicine is now one of the country's strongest advocates for the principle of hemostatic resuscitation using whole blood or balanced blood components as the primary means of resuscitation as early as possibly following severe trauma. Based on strong evidence to support this practice in human combat casualties and in civilian trauma care, military veterinarians strive to practice similar hemostatic resuscitation for injured Military Working Dogs. To this end, canine whole blood has become increasingly available in forward environments, and non-traditional storage options for canine blood and blood components are being explored for use in canine trauma. Blood products with improved shelf-life and ease of use are not only useful for military applications, but may also enable civilian general and specialty practices to more easily incorporate hemostatic resuscitation approaches to canine trauma care.

scholarly journals Whole blood for hemostatic resuscitation of major bleeding

Transfusion ◽  
2016 ◽  
Vol 56 ◽  
pp. S190-S202 ◽  
Author(s):  
Philip C. Spinella ◽  
Heather F. Pidcoke ◽  
Geir Strandenes ◽  
Tor Hervig ◽  
Andrew Fisher ◽  
...  
Keyword(s):  
Major Bleeding ◽  
Whole Blood ◽  
Hemostatic Resuscitation

scholarly journals Hemostatic resuscitation for massive hemorrhage with warm fresh whole blood in a patient with severe blunt trauma

2014 ◽  
Vol 37 (4) ◽  
pp. 205-207 ◽  
Author(s):  
Yuan-Hao Liu ◽  
Chia-Sheng Chao ◽  
Yee-Phoung Chang ◽  
Hsien-Kuo Chin
Keyword(s):  
Blunt Trauma ◽  
Whole Blood ◽  
Massive Hemorrhage ◽  
Hemostatic Resuscitation

scholarly journals An analysis of outcomes for pediatric trauma warm fresh whole blood recipients in Iraq and Afghanistan

Transfusion ◽  
2021 ◽  
Vol 61 (S1) ◽  
Author(s):  
Ryann S. Lauby ◽  
Camaren M. Cuenca ◽  
Matthew A. Borgman ◽  
Andrew D. Fisher ◽  
Vikhyat S. Bebarta ◽  
...  
Keyword(s):  
Whole Blood ◽  
Pediatric Trauma

Nationwide analysis of whole blood hemostatic resuscitation in civilian trauma

2020 ◽  
Vol 89 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Kamil Hanna ◽  
Letitia Bible ◽  
Mohamad Chehab ◽  
Samer Asmar ◽  
Molly Douglas ◽  
...  
Keyword(s):  
Whole Blood ◽  
Hemostatic Resuscitation ◽  
Civilian Trauma

Hemostatic Resuscitation of Pediatric Trauma Patients During Air Medical Transport: A Retrospective Matched Cohort Study

2021 ◽  
Author(s):  
Cedric P. Van Dijck ◽  
Lynn G. Stansbury ◽  
Andrew J. Latimer ◽  
Elissa K. Butler ◽  
Rajen Nathwani ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pediatric Trauma ◽  
Trauma Patients ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Hemostatic Resuscitation ◽  
Medical Transport

scholarly journals Whole Blood for Blood Loss: Hemostatic Resuscitation in Damage Control

2020 ◽  
Author(s):  
Juan Carlos Salamea ◽  
Amber Himmler ◽  
Laura Isabel Valencia-Angel ◽  
Carlos Alberto Ordoñez ◽  
Michael Parra ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Damage Control ◽  
Fresh Frozen Plasma ◽  
Trauma Patients ◽  
Damage Control Resuscitation ◽  
Middle Income ◽  
Packed Red Blood Cells ◽  
Hemostatic Resuscitation ◽  
Fresh Frozen

Hemorrhagic shock and its complications are a major cause of death among trauma patients. The management of hemorrhagic shock using a damage control resuscitation strategy has been shown to decrease mortality and improve patient outcomes. One of the components of damage control resuscitation is hemostatic resuscitation, which involves the replacement of lost blood volume with components such as packed red blood cells, fresh frozen plasma, cryoprecipitate, and platelets in a 1:1:1:1 ratio. However, this is a strategy that is not applicable in many parts of Latin America and other low-and-middle-income countries throughout the world, where there is a lack of well-equipped blood banks and an insufficient availability of blood products. To overcome these barriers, we propose the use of cold fresh whole blood for hemostatic resuscitation in exsanguinating patients. Over 6 years of experience in Ecuador has shown that resuscitation with cold fresh whole blood has similar outcomes and a similar safety profile compared to resuscitation with hemocomponents. Whole blood confers many advantages over component therapy including, but not limited to the transfusion of blood with a physiologic ratio of components, ease of transport and transfusion, less volume of anticoagulants and additives transfused to the patient, and exposure to fewer donors. Whole blood is a tool with reemerging potential that can be implemented in civilian trauma centers with optimal results and less technical demand.

scholarly journals Is the Whole Greater Than the Sum of Its Parts? The Implementation and Outcomes of a Whole Blood Program in Ecuador

2020 ◽  
Author(s):  
Amber Nicole Himmler ◽  
Monica Eulalia Galarza Armijos ◽  
Jeovanni Reinoso Naranjo ◽  
Sandra Gioconda Peña Patiño ◽  
Doris Sarmiento Altamirano ◽  
...  
Keyword(s):  
Latin America ◽  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Vital Signs ◽  
Acute Care Surgery ◽  
Transfusion Reaction ◽  
Shock Index ◽  
Middle Income ◽  
Hemostatic Resuscitation ◽  
Care Surgery

Abstract Background: Hemorrhagic shock is a major cause of mortality in low-and-middle-income countries (LMICs). Many institutions in LMICs lack the resources to adequately prescribe balanced resuscitation. This study aims to describe the implementation of a whole blood program in Latin America and discuss the outcomes of the patients that received whole blood (WB). Methods: We conducted a retrospective review of patients resuscitated with WB from 2013-2019. Five units of O+ WB were made available on a consistent basis for patients presenting in hemorrhagic shock. Variables collected included: sex, age, service treating the patient, units of WB administered, units of components administered, admission vital signs, admission hemoglobin, Shock Index, intraoperative crystalloid and colloid administration, symptoms of transfusion reaction, length-of-stay and in-hospital mortality.Results: The sample includes a total of 101 patients, 57 of whom were trauma and acute care surgery (TACS) patients and 44 of whom were obstetrics and gynecology patients. No patients developed symptoms consistent with a transfusion reaction. Average shock index was 1.16 (±0.55). On average, patients received 1.66 (±0.80) units of whole blood. Overall mortality was 14/101 (13.86%) in the first 24 hours and 6/101 (5.94%) after 24 hours.Conclusion: Implementing a WB protocol is achievable in LMICs. Whole blood allows for more efficient delivery of hemostatic resuscitation and is ideal for resource-restrained settings. To our knowledge, this is the first description of a whole blood program implemented in a civilian hospital in Latin America.

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