scholarly journals Functional Connectivity is Reduced in Early-stage Primary Progressive Aphasia When Atrophy is not Prominent

2017 ◽  
Vol 31 (2) ◽  
pp. 101-106 ◽  
Author(s):  
Borna Bonakdarpour ◽  
Emily J. Rogalski ◽  
Allan Wang ◽  
Jaiashre Sridhar ◽  
M.M. Mesulam ◽  
...  
2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P794-P794
Author(s):  
Boon Lead Tee ◽  
Maria Luisa Gorno Tempini ◽  
Ariane E. Welch

BMC Neurology ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ryota Kobayashi ◽  
Hiroshi Hayashi ◽  
Shinobu Kawakatsu ◽  
Aiko Ishiki ◽  
Nobuyuki Okamura ◽  
...  

2018 ◽  
Vol 19 ◽  
pp. 703-715 ◽  
Author(s):  
Bronte N. Ficek ◽  
Zeyi Wang ◽  
Yi Zhao ◽  
Kimberly T. Webster ◽  
John E. Desmond ◽  
...  

2020 ◽  
Author(s):  
Haroon Popal ◽  
Megan Quimby ◽  
Daisy Hochberg ◽  
Bradford C. Dickerson ◽  
Jessica A. Collins

AbstractAs their illness progresses, patients with the semantic variant of Primary Progressive Aphasia (svPPA) frequently exhibit peculiar behaviors indicative of altered visual attention or an increased interest in artistic endeavors. In the present study, we examined changes within and between large-scale functional brain networks that may explain this altered visual behavior. We first examined the connectivity of the visual association network, the dorsal attention network, and the default mode network in healthy young adults (n=89) to understand the typical architecture of these networks in the healthy brain. We then compared the large-scale functional connectivity of these networks in a group of svPPA patients (n=12) to a group of age-matched cognitively normal controls (n=30). Our results showed that the between-network connectivity of the dorsal attention and visual association networks was elevated in svPPA patients relative to controls. We further showed that this heightened between-network connectivity was associated with a decrease in the within-network connectivity of the default mode network, possibly due to progressive degeneration of the anterior temporal lobes in svPPA. These results suggest that focal neurodegeneration can lead to the reorganization of large-scale cognitive networks beyond the primarily affected network(s), possibly contributing to cognitive or behavioral changes that are commonly present as part of the clinical phenotype of svPPA.


Brain ◽  
2017 ◽  
Vol 140 (10) ◽  
pp. 2737-2751 ◽  
Author(s):  
Kamalini G Ranasinghe ◽  
Leighton B Hinkley ◽  
Alexander J Beagle ◽  
Danielle Mizuiri ◽  
Susanne M Honma ◽  
...  

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