Correlation of Inner Retinal Thickness Evaluated by Spectral-Domain Optical Coherence Tomography and Contrast Sensitivity in Parkinson disease

Background. Retinopathy of prematurity (ROP) is a condition of abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) of RVD in oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between retinal structural and vascular changes using simultaneous FA and spectral domain optical coherence tomography (SD-OCT). Method. 63 mice were exposed to 77% oxygen at postnatal day 7 (P7) for 5 days, while 63 mice remained in room air (RA). Total retinal thickness (TRT), inner retinal thickness (IRT), and outer retinal thickness (ORT) were calculated at early (P19), mid (P24), late (P32), and mature (P47) phases of RVD. Results. TRT was reduced in OIR (162.66 ± 17.75 μm, n=13) compared to RA mice at P19 (197.57 ± 3.49 μm, n=14), P24, P32, and P49 (P<0.0001). ORT was similar in RA and OIR mice at all ages (P>0.05). IRT was reduced in OIR (71.60 ± 17.14 μm) compared to RA (103.07 ± 3.47 μm) mice at P19 and all ages (P<0.0001). Conclusion. We have shown the spatial and temporal relationship between retinal structure and vascular development in OIR. Significant inner retinal thinning in OIR mice persisted despite revascularization of the capillary network; further studies will elucidate its functional implications in ROP.

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Evaluation of Retinal Thickness in Neurodegenerative Diseases using Spectral Domain Optical Coherence Tomography

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2018/35661.11869 ◽

2018 ◽

Author(s):

Bindu Madhavi Manapragada ◽

Shobha G Pai ◽

Susan D Souza ◽

Madhurima K Nayak

Keyword(s):

Optical Coherence Tomography ◽

Neurodegenerative Diseases ◽

Retinal Thickness ◽

Spectral Domain ◽

Optical Coherence

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Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

10.21203/rs.3.rs-133611/v1 ◽

2020 ◽

Author(s):

Mojtaba Abrishami ◽

Fariba Tohidinezhad ◽

Zahra Emamverdian ◽

Ramin Daneshvar ◽

Neda Saeedian ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Case Group ◽

Special Focus ◽

Optical Coherence ◽

Cross Sectional ◽

Significant Difference ◽

Normal Controls ◽

Sd Oct

Abstract Purpose: To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19).Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls.Results: Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups. However, the thickness in the case group was minimally more than the controls. Conclusion: Retinal thickness in COVID-19 patients may be higher than healthy subjects. Comprehensive ocular examination with special focus on posterior segment manifestations should be considered in these patients.

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