The antagonism between botulinum toxin and calcium in motor nerve terminals

The effects of tetraethylammonium and manganese, which modify calcium entry into motor nerve terminals, have been studied during advanced stages of botulinum paralysis. Evidence has been obtained that the voltage-activated calcium current in the nerve endings is not significantly reduced by botulinum toxin. The depression of transmitter release that the toxin produces must arise at a later stage, at an intracellular site of the release mechanism.

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Multiple types of calcium channels mediate transmitter release during functional recovery of botulinum toxin type A-poisoned mouse motor nerve terminals

Neuroscience ◽

10.1016/s0306-4522(99)00382-6 ◽

1999 ◽

Vol 95 (1) ◽

pp. 227-234 ◽

Cited By ~ 35

Author(s):

M.M. Santafé ◽

F.J. Urbano ◽

M.A. Lanuza ◽

O.D. Uchitel

Keyword(s):

Botulinum Toxin ◽

Calcium Channels ◽

Functional Recovery ◽

Transmitter Release ◽

Motor Nerve ◽

Botulinum Toxin Type A ◽

Type A ◽

Botulinum Toxin Type ◽

Nerve Terminals ◽

Motor Nerve Terminals

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Transmitter release triggered by a local depolarization in motor nerve terminals of the frog: Role of calcium entry and of depolarization

Neuroscience Letters ◽

10.1016/0304-3940(83)90235-5 ◽

1983 ◽

Vol 41 (1-2) ◽

pp. 133-138 ◽

Cited By ~ 23

Author(s):

J. Dudel

Keyword(s):

Transmitter Release ◽

Motor Nerve ◽

Calcium Entry ◽

Nerve Terminals ◽

Motor Nerve Terminals

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The interaction of presynaptic polarization with calcium and magnesium in modifying spontaneous transmitter release from mammalian motor nerve terminals

The Journal of Physiology ◽

10.1113/jphysiol.1969.sp008864 ◽

1969 ◽

Vol 203 (2) ◽

pp. 281-299 ◽

Cited By ~ 19

Author(s):

E. M. Landau

Keyword(s):

Transmitter Release ◽

Motor Nerve ◽

Nerve Terminals ◽

Motor Nerve Terminals ◽

Calcium And Magnesium

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Transmitter release induced by a ‘factor’ in rabbit serum

Proceedings of the Royal Society of London Series B Biological Sciences ◽

10.1098/rspb.1974.0072 ◽

1974 ◽

Vol 187 (1087) ◽

pp. 235-241 ◽

Cited By ~ 28

Keyword(s):

Complement System ◽

Transmitter Release ◽

Motor Nerve ◽

Nerve Endings ◽

Rabbit Serum ◽

Nerve Terminals ◽

The Complement System ◽

The Way

Non-heated rabbit serum causes massive transmitter release from motor nerve endings. The effect is not observed after heating the serum, in the way usually done to destroy complement. It seems that serum may be acting on the nerve terminals by a mechanism involving the complement system in the absence of antibody.

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