Extra-junctional ryanodine receptors in the terminal cisternae of mammalian skeletal muscle fibres

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Nikolay S. Shelud’ko ◽  
Yurii S. Borovikov

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Csaba Szegedi ◽  
István Jona ◽  
...  

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Rainer Fink

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Julio L. Vergara

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...  

The coupling process at the triadic junctions in skeletal muscle fibres is characterized by a significant latency between the depolarization of the transverse tubular membrane and the release of Ca from the sarcoplasmic reticulum. This time interval, the triadic delay, is sufficiently long to allow for the participation of a chemical process. The strong temperature dependence of the triadic delay ( Q 10 near 2.7) suggests that a sequence of chemical steps may link the electical signal in the T-tubules to the opening of Ca channels in the terminal cisternae of the sarcoplasmic reticulum.


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