scholarly journals Simian immunodeficiency virus in kidney cell cultures from highly infected rhesus macaques ( Macaca mulatta )

2001 ◽  
Vol 356 (1410) ◽  
pp. 845-847 ◽  
Author(s):  
Philippe Lena ◽  
Paul Luciw
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Cell Cultures ◽  
Macaca Mulatta ◽  
Kidney Cell ◽  
Lymphoid Cell ◽  
Rhesus Macaques ◽  
Kidney Cells ◽  
Lymphoid Cell Line ◽  
Highly Pathogenic ◽  
Immunodeficiency Virus

Trace amounts of simian immunodeficiency virus (SIV) proviral DNA were detected in monolayers of primary kidney cells from two rhesus macaques ( Macaca mulatta ) heavily infected with the highly pathogenic strain SIVmac251. There was no detectable infectious SIV in the supernatant from the kidney cell cultures obtained from either monkey. However, infectious SIV was rescued by co–culture of kidney cells with a permissive lymphoid cell line. Macrophages, present in these cultures, may be the reservoir for the proviral genomes.

scholarly journals Atypical nodular astrocytosis in simian immunodeficiency virus-infected rhesus macaques (Macaca mulatta )

2014 ◽  
Vol 43 (6) ◽  
pp. 468-476
Author(s):  
Keiko Y. Petrosky ◽  
Heather L. Knight ◽  
Susan V. Westmoreland ◽  
Andrew D. Miller
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Immunodeficiency Virus

Immunohistochemical detection of simian immunodeficiency virus (SIV) in rectal mucosa of experimentally infected rhesus macaques (Macaca mulatta)

2001 ◽  
Vol 103 (1) ◽  
pp. 79-88 ◽  
Author(s):  
Franz-Josef Kaup ◽  
Juan Antonio Boga ◽  
Savio Freire Bruno ◽  
Andrea Didier ◽  
Katrin Hermann ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Rectal Mucosa ◽  
Immunohistochemical Detection ◽  
Immunodeficiency Virus

scholarly journals Simian Immunodeficiency Virus (SIV) gp130 Oligomers Protect Rhesus Macaques (Macaca mulatta) against the Infection with SIVmac32H Grown on T-Cells or Derivedex Vivo

Virology ◽  
1996 ◽  
Vol 216 (2) ◽  
pp. 444-450 ◽  
Author(s):  
WOLFGANG LÜKE ◽  
CHEICK COULIBALY ◽  
ULF DITTMER ◽  
GERALD VOSS ◽  
REINHARD OESTERLE ◽  
...  
Keyword(s):  
T Cells ◽  
Simian Immunodeficiency Virus ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Immunodeficiency Virus

scholarly journals Long-Lasting Decrease in Viremia in Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251 after Therapeutic DNA Immunization

2006 ◽  
Vol 81 (4) ◽  
pp. 1972-1979 ◽  
Author(s):  
Agneta S. von Gegerfelt ◽  
Margherita Rosati ◽  
Candido Alicea ◽  
Antonio Valentin ◽  
Patricia Roth ◽  
...  
Keyword(s):  
Immune Responses ◽  
Simian Immunodeficiency Virus ◽  
Rhesus Macaques ◽  
Antiretroviral Drugs ◽  
Therapeutic Vaccination ◽  
Highly Pathogenic ◽  
Cellular Immune Responses ◽  
Immunodeficiency Virus ◽  
Cellular Immune ◽  
Dna Vectors

ABSTRACT Rhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P = 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy.

scholarly journals Trichomonad Gastritis in Rhesus Macaques (Macaca mulatta) Infected with Simian Immunodeficiency Virus

2005 ◽  
Vol 42 (1) ◽  
pp. 19-29 ◽  
Author(s):  
I. Kondova ◽  
M. A. Simon ◽  
S. A. Klumpp ◽  
J. MacKey ◽  
G. Widmer ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Immunodeficiency Virus

Enterocytozoon bieneusi as a Cause of Proliferative Serositis in Simian Immunodeficiency Virus–Infected Immunodeficient Macaques (Macaca mulatta)

2000 ◽  
Vol 124 (10) ◽  
pp. 1480-1484
Author(s):  
Laura V. Chalifoux ◽  
Angela Carville ◽  
Douglas Pauley ◽  
Brendon Thompson ◽  
Andrew A. Lackner ◽  
...  
Keyword(s):  
Simian Immunodeficiency Virus ◽  
Macaca Mulatta ◽  
Rhesus Macaques ◽  
Severe Infection ◽  
Small Subunit ◽  
Enterocytozoon Bieneusi ◽  
Ribosomal Gene ◽  
Etiologic Agent ◽  
Microsporidian Parasite ◽  
Immunodeficiency Virus

Abstract Context.—Enterocytozoon bieneusi is the most frequent microsporidian parasite of human patients with acquired immunodeficiency syndrome and is a significant cause of diarrhea and wasting. Recently, this organism has also been recognized as a spontaneous infection of several species of captive macaques. As in humans, E bieneusi frequently causes enteropathy and cholangiohepatitis in immunodeficient simian immunodeficiency virus (SIV)–infected macaques. Objective.—To examine E bieneusi as an etiologic agent of nonsuppurative proliferative serositis in immunodeficient rhesus macaques (Macaca mulatta). Design.—Retrospective analysis of necropsy material obtained from immunodeficient SIV-infected rhesus macaques. Results.—Examination of SIV-infected rhesus macaques (n = 225) revealed E bieneusi proliferative serositis in 7 of 16 cases of peritonitis of unknown origin. The organism could be identified by in situ hybridization and polymerase chain reaction in sections of pleura and peritoneum obtained at necropsy. Serositis was always accompanied by moderate-to-severe infection of the alimentary tract, and morphologic evidence suggested dissemination through efferent lymphatics. Colabeling experiments revealed most infected cells to be cytokeratin positive and less frequently positive for the macrophage marker CD68. Sequencing of a 607–base pair segment of the small subunit ribosomal gene revealed 100% identity to sequences obtained from rhesus macaques (Genbank accession AF023245) and human patients (Genbank accession AF024657 and L16868). Conclusions.—These findings indicate that E bieneusi disseminates in immunodeficient macaques and may be a cause of peritonitis in the immunocompromised host.

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