scholarly journals Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice

2010 ◽  
Vol 91 (6) ◽  
pp. 1473-1477 ◽  
Author(s):  
S. Bereczky ◽  
G. Lindegren ◽  
H. Karlberg ◽  
S. Akerstrom ◽  
J. Klingstrom ◽  
...  
Keyword(s):  
Virus Infection ◽  
Knockout Mice ◽  
Type I Interferon ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Type I ◽  
Adult Type ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Interferon Receptor

scholarly journals Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean–Congo hemorrhagic fever virus

2012 ◽  
Vol 93 (3) ◽  
pp. 560-564 ◽  
Author(s):  
Stuart D. Dowall ◽  
Stephen Findlay-Wilson ◽  
Emma Rayner ◽  
Geoff Pearson ◽  
Janice Pickersgill ◽  
...  
Keyword(s):  
Type I Interferon ◽  
Antiviral Agents ◽  
Disease Model ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Type I ◽  
Adult Type ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Interferon Receptor

Hazara virus (HAZV) is closely related to the Crimean–Congo hemorrhagic fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose–response effects were seen with higher doses, resulting in a shorter time to death and earlier detection of viral loads in organs. The lowest dose of 10 p.f.u. was still lethal in over 50 % of the mice. Histopathological findings were identified in the liver, spleen and lymph nodes, with changes similar to a recent mouse model of CCHFV infection. The findings demonstrate that inoculation of mice with HAZV may act as a useful surrogate model for the testing of antiviral agents against CCHFV.

Type I interferon inhibits Crimean-Congo hemorrhagic fever virus in human target cells

2005 ◽  
Vol 78 (2) ◽  
pp. 216-222 ◽  
Author(s):  
Ida Andersson ◽  
Åke Lundkvist ◽  
Otto Haller ◽  
Ali Mirazimi
Keyword(s):  
Type I Interferon ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Target Cells ◽  
Type I ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

Hepatocyte pathway alterations in response to in vitro Crimean Congo hemorrhagic fever virus infection

2014 ◽  
Vol 179 ◽  
pp. 187-203 ◽  
Author(s):  
Christophe Fraisier ◽  
Raquel Rodrigues ◽  
Vinh Vu Hai ◽  
Maya Belghazi ◽  
Stéphanie Bourdon ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

scholarly journals Risk factors for Crimean-Congo hemorrhagic fever virus infection in Livestock in Pakistan

2019 ◽  
Vol 79 ◽  
pp. 137 ◽  
Author(s):  
K.K. Kasi ◽  
M.A. Sas ◽  
C. Sauter-Louis ◽  
J.M. Gethmann ◽  
M.H. Groschup ◽  
...  
Keyword(s):  
Risk Factors ◽  
Virus Infection ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

scholarly journals Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice

2015 ◽  
Vol 15 (12) ◽  
pp. 759-764 ◽  
Author(s):  
Jeroen Kortekaas ◽  
Rianka P.M. Vloet ◽  
Alexander J. McAuley ◽  
Xiaoli Shen ◽  
Berend Jan Bosch ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Neutralizing Antibodies ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Subunit Vaccines ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus

Efficacy of favipiravir (T-705) against Crimean-Congo hemorrhagic fever virus infection in cynomolgus macaques

2020 ◽  
Vol 181 ◽  
pp. 104858 ◽  
Author(s):  
David W. Hawman ◽  
Elaine Haddock ◽  
Kimberly Meade-White ◽  
Glenn Nardone ◽  
Friederike Feldmann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Hemorrhagic Fever ◽  
Fever Virus ◽  
Crimean Congo Hemorrhagic Fever ◽  
Hemorrhagic Fever Virus ◽  
Cynomolgus Macaques
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