scholarly journals Effect of nandrolone decanoate on healing of experimentally induced radial nonunion in rabbits (Oryctolagus cuniculus)

2021 ◽  
Author(s):  
Adrielly Dissenha ◽  
Bruno Minto ◽  
Karina Calciolari ◽  
Laís Fernanda Sargi ◽  
Lismara Castro Do Nascimento ◽  
...  
Keyword(s):  
Placebo Group ◽  
New Zealand ◽  
Young Adult ◽  
Oryctolagus Cuniculus ◽  
Nacl Solution ◽  
Nandrolone Decanoate ◽  
Large Defect ◽  
New Zealand White Rabbits ◽  
Bone Nonunion ◽  
Primary Bone

The aim of this study was to evaluate the effect of nandrolone decanoate (ND) on treatment of bone nonunion in the radius of rabbits. Thirty-one, young adult, New Zealand White rabbits (Oryctolagus cuniculus) were allocated to one of four groups: nandrolone males (NMG), nandrolone females (NFG), placebo males (NPM), and placebo females (NPF). After bone nonunion of a 10 mm ostectomy of the radius was confirmed (45 days after surgery), the animals in the NMG and NFG groups received 10 mg/kg ND intramuscular once a week for four weeks, while placebo groups received intramuscular 0.9% NaCl solution. Radiographic, histopathologic, and densitometric parameters (DXA) were used to compared groups. Results: No significant differences were observed radiographically. However, ND groups showed greater area (P=0.0258) and BMC (P=0.0140) in the densitometric evaluation. Histologically, the placebo group showed a predominance of primary bone tissue. Whereas, lamellary organizations of secondary bone and the presence of fibrocartilage were found in the ND group (P =0.006). In conclusion, ND promoted bone regeneration after the creation of a large defect in the radius of rabbits.

Panting in small mammals: a comparison of two marsupials and the laboratory rabbit

1977 ◽  
Vol 42 (4) ◽  
pp. 537-544 ◽  
Author(s):  
S. C. Nicol ◽  
M. Maskrey
Keyword(s):  
Oxygen Consumption ◽  
New Zealand ◽  
Rectal Temperature ◽  
Oryctolagus Cuniculus ◽  
Minute Volume ◽  
Evaporative Heat Loss ◽  
Thermoneutral Zone ◽  
New Zealand White Rabbits ◽  
Laboratory Rabbit ◽  
Potorous Tridactylus

By use of a barometric technique, tidal volume (VT), minute volume (VE), respiratory frequency (f), and respiratory evaporative heat loss (Eex) were measured from conscious unrestrained potoroos (Potorous tridactylus), barred bandicoots (Perameles gunnii), and New Zealand white rabbits (Oryctolagus cuniculus) at temperatures in and above the thermoneutral zone (TNZ). Rectal temperature (Tre) and oxygen consumption were also measured. VT initially decreased with rising Ta, but in the potoroo and rabbit it then increased past the resting level. VE increased much more in the marsupials than in the rabbit, and higher Eex maxima were also found for the marsupials. The marsupials had high Q10's above the TNZ, and had a panting efficiency of 80%. The rabbits had a Q10 of 1.9 above the TNZ and 100% panting efficiency. The high VE and Eex and low panting efficiency of the marsupials may be due to their lower Tre which allows transfer of heat from the environment to the animal.

Pharmacokinetics of maropitant citrate in New Zealand White rabbits (Oryctolagus cuniculus)

2019 ◽  
Vol 80 (10) ◽  
pp. 963-968
Author(s):  
Sarah M. Ozawa ◽  
Michelle G. Hawkins ◽  
Tracy L. Drazenovich ◽  
Philip H. Kass ◽  
Heather K. Knych
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
New Zealand White Rabbits

Pharmacokinetics and safety of ceftiofur crystalline free acid in New Zealand White rabbits (Oryctolagus cuniculus)

2017 ◽  
Vol 78 (7) ◽  
pp. 796-803 ◽  
Author(s):  
Sara Gardhouse ◽  
David Sanchez-Migallon Guzman ◽  
Sherry Cox ◽  
Philip H. Kass ◽  
Tracy L. Drazenovich ◽  
...  
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Free Acid ◽  
New Zealand White Rabbits

scholarly journals Systemic absortion and adverse effects of topical ocular use of ketorolac tromethamine and sodium diclofenac in New Zealand rabbits for 90 days

2019 ◽  
Vol 71 (6) ◽  
pp. 1865-1872 ◽  
Author(s):  
F.Q. Pereira ◽  
B. Santos ◽  
T. Carboni ◽  
M. Bender ◽  
D. Driemeier ◽  
...  
Keyword(s):  
New Zealand ◽  
Solid Phase ◽  
Diclofenac Sodium ◽  
Systemic Absorption ◽  
Ketorolac Tromethamine ◽  
Nacl Solution ◽  
Laboratory Examination ◽  
New Zealand White Rabbits ◽  
Laboratory Results ◽  
And Control

ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their separation and identification in the plasma. At the end of the treatment, the animals were euthanized and necropsied, and no macroscopic or microscopic changes were found. This observation confirmed the laboratory results, which were within normal reference standards for the species. According to the results obtained, it can be concluded that treatment with eyedrops containing KT and DS for 90 days in healthy rabbits does not cause adverse systemic effects.

scholarly journals Continuous Rate Infusion of Ketamine Hydrochloride and Dexmedetomidine for Maintenance of Anesthesia during Laryngotracheal Surgery in New Zealand White Rabbits (Oryctolagus cuniculus)

2020 ◽  
Vol 59 (2) ◽  
pp. 176-185
Author(s):  
Lea J Sayce ◽  
Maria E Powell ◽  
Emily E Kimball ◽  
Patty Chen ◽  
Gary J Gartling ◽  
...  
Keyword(s):  
New Zealand ◽  
Oryctolagus Cuniculus ◽  
Vocal Fold ◽  
Muscle Tone ◽  
In Vivo Model ◽  
Topical Lidocaine ◽  
New Zealand White Rabbits ◽  
Ketamine Hydrochloride ◽  
Rate Infusion

New Zealand white rabbits (Oryctolagus cuniculus) are an established in vivo model for the study of structural and functional consequences of vocal-fold vibration. Research design requires invasive laryngotracheal procedures, and the presence of laryngospasms or pain responses (or both) hinder phonation-related data collection. Published anesthesia regimens report respiratory depression and muscle tone changes and have been unsuccessful in mitigating autonomic laryngeal responses in our protocol. Infusion of ketamine hydrochloride and dexmedetomidine hydrochloride in pediatric medicine provides effective analgesia and sedation for laryngotracheal procedures including intubation and bronchoscopy; however, data evaluating the use of ketamine–dexmedetomidine infusion in rabbits are unavailable. This study reports a new infusion regimen, which was used in 58 male New Zealand white rabbits that underwent a nonsurvival laryngotracheal procedure to induce phonotraumatic vocal-fold injury. Animals were sedated by using ketamine hydrochloride (20 mg/kg IM) and dexmedetomidine (0.125 mg/kg IM). Maintenance anesthesia was provided by using continuous rate intravenous infusion of ketamine hydrochloride (343 μg/kg/min) and dexmedetomidine (1.60 μg/kg/min). A stable plane of anesthesia with no autonomic laryngeal response (laryngospasm) was achieved in 32 of the 58 rabbits (55%). Laryngospasms occurred in 25 of 58 animals (43%) and were controlled in 20 cases (80%) by providing 0.33 mL 2% topical lidocaine, incremental increase in infusion rate, or both. Continuous rate infusion of ketamine hydrochloride–dexmedetomidine with prophylactic topical lidocaine provides a predictable and adjustable surgical plane of anesthesia, with minimal confounding respiratory and autonomic laryngeal responses, during extended-duration laryngotracheal surgery in rabbits. This regimen should be considered as an alternative to injection maintenance for prolonged, invasive procedures.

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