scholarly journals Understanding the psychological journey of patients with head and neck cancer in different periods: a qualitative study protocol

2021 ◽  
Author(s):  
Li YIN ◽  
Ping CHENG ◽  
Yijian LI ◽  
Chunlian YANG ◽  
Ren JIANG ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Qualitative Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Head And Neck Tumors ◽  
Psychological Status ◽  
Data Ethics ◽  
Neck Tumors ◽  
The World ◽  
Hospital Ethics

Abstract Introduction There are more than 900,000 new cases of head and neck tumors in the world every year, which is the sixth most common tumor in the world. During the treatment of head and neck cancer, patients often face various symptoms and psychological problems. In this qualitative study, patients with head and neck cancer were invited to share their psychological journey during diagnosis, treatment, and recovery to (1) understand their psychological status and feelings during different treatment stages, (2) their needs and concerns during different treatment stages, and (3) difficulties and problems in self-management. Methods and analysis We adopt qualitative study to understand these patient psychological journey with head and neck cancer, especially when they are at different times in the diagnosis, treatment and completion of head and neck tumors. Thematic analysis will be carried out following the six-phase iterative process suggested by Braun and Clarke: (1) familiarising oneself with data, (2) generating initial codes, (3) searching for themes, (4) reviewing themes,(5) defining and naming themes and (6) providing the report, which will be used to analyse the qualitative data. Ethics and dissemination This study has ethical approval from the Sichuan Cancer Hospital Ethics Committee. We will disseminate the findings through national and international conferences and international peer-reviewed journals. Strengths and limitations In this study, qualitative research was used to better understand the psychological process and feelings of patients with head and neck tumor at different stages of treatment. The subjects were interviewed in the same tumor hospital. Patients in different grade hospitals in different regions may have different psychological processes and experiences.

VISUALIZATION OF HEAD AND NECK CANCER MODELS WITH A TRIPLE FUSION REPORTER GENE

2012 ◽  
Vol 05 (04) ◽  
pp. 1250028 ◽  
Author(s):  
YING ZHENG ◽  
QIAOYA LIN ◽  
HONGLIN JIN ◽  
JUAN CHEN ◽  
ZHIHONG ZHANG
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Tumor Growth ◽  
Head And Neck ◽  
Reporter Gene ◽  
Neck Cancer ◽  
Bioluminescence Imaging ◽  
Head And Neck Tumors ◽  
Neck Tumors

The development of experimental animal models for head and neck tumors generally rely on the bioluminescence imaging to achieve the dynamic monitoring of the tumor growth and metastasis due to the complicated anatomical structures. Since the bioluminescence imaging is largely affected by the intracellular luciferase expression level and external D-luciferin concentrations, its imaging accuracy requires further confirmation. Here, a new triple fusion reporter gene, which consists of a herpes simplex virus type 1 thymidine kinase (TK) gene for radioactive imaging, a far-red fluorescent protein (mLumin) gene for fluorescent imaging, and a firefly luciferase gene for bioluminescence imaging, was introduced for in vivo observation of the head and neck tumors through multi-modality imaging. Results show that fluorescence and bioluminescence signals from mLumin and luciferase, respectively, were clearly observed in tumor cells, and TK could activate suicide pathway of the cells in the presence of nucleotide analog-ganciclovir (GCV), demonstrating the effectiveness of individual functions of each gene. Moreover, subcutaneous and metastasis animal models for head and neck tumors using the fusion reporter gene-expressing cell lines were established, allowing multi-modality imaging in vivo. Together, the established tumor models of head and neck cancer based on the newly developed triple fusion reporter gene are ideal for monitoring tumor growth, assessing the drug therapeutic efficacy and verifying the effectiveness of new treatments.

scholarly journals Association between PD-L1 expression and head and neck cancer prognosis: a meta-analysis

2019 ◽  
Author(s):  
Zhisen Shen ◽  
Linrong Wu ◽  
Xianlei Cai ◽  
Dong Ye ◽  
Gangjun Zhao
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Head And Neck Tumors ◽  
Cancer Prognosis ◽  
Cochrane Library ◽  
Prognostic Impact ◽  
Poor Prognostic Factor ◽  
Neck Tumors

Abstract Background: Programmed cell death ligand 1（PD-L1) plays an important role in tumor cell immune escape, and it has been extensively studied in head and neck cancer. However, its prognostic impact on patients with head and neck cancer remains controversial, so we sought to investigate this issue through a comprehensive meta-analysis. Methods: To assess the significance of PD-L1 on the survival of patients with head and neck cancer, we collected articles reported in PubMed, EMBASE, and Cochrane Library, until January 31, 2019. We also used the Newcastle Ottawa Scale (NOS) for literature quality evaluation. Results: The study included a total of 4551 patients affected by 6 different types of head and neck cancer reported in 26 articles. Our study found that the association between the expression of PD-L1 and the prognosis of head and neck tumors was highly heterogeneous (P < 0.00001, I2 = 80.0%); therefore, the random effects model was applied to combine the effect sizes. Based on the combined hazard ratios (HR)of 1.15 (95% CI: 0.88 to 1.50, P = 0.32), the expression of PD-L1 in head and neck tumors may not be a factor associated with poor prognosis. Conclusions: Our results suggest that PD-L1 expression cannot predict the overall survival of patients with oral, nasopharyngeal, or esophageal cancer. Through subgroup analysis, we found that the expression of PD-L1 may be a poor prognostic factor for some head and neck cancers.

Changes in intimate relationships following treatment for head and neck cancer—A qualitative study

2017 ◽  
Vol 35 (5) ◽  
pp. 614-630 ◽  
Author(s):  
Christina Stenhammar ◽  
Joakim Isaksson ◽  
Brith Granström ◽  
Göran Laurell ◽  
Ylva Tiblom Ehrsson
Keyword(s):  
Head And Neck Cancer ◽  
Qualitative Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Intimate Relationships

A qualitative study of head and neck cancer

2004 ◽  
Vol 12 (5) ◽  
pp. 338-346 ◽  
Author(s):  
F. R. Khuri ◽  
R. J. Moore ◽  
R. M. Chamberlain
Keyword(s):  
Head And Neck Cancer ◽  
Qualitative Study ◽  
Head And Neck ◽  
Neck Cancer

Experiences of xerostomia after radiotherapy in patients with head and neck cancer: A qualitative study

2017 ◽  
Vol 27 (1-2) ◽  
pp. e100-e108 ◽  
Author(s):  
Nan Jiang ◽  
Yue Zhao ◽  
Henrik Jansson ◽  
Xiaocen Chen ◽  
Jan Mårtensson
Keyword(s):  
Head And Neck Cancer ◽  
Qualitative Study ◽  
Head And Neck ◽  
Neck Cancer

Information service in head and neck cancer care—a qualitative study

2017 ◽  
Vol 26 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Violet D’Souza ◽  
Maiziel Serrao ◽  
Erin Watson ◽  
Elizabeth Blouin ◽  
Anthony Zeitouni ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Qualitative Study ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Care ◽  
Information Service

Contemplation of head and neck intensity-modulated radiotherapy

2008 ◽  
Vol 7 (2) ◽  
pp. 61-66
Author(s):  
T.A. Rose
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Intensity Modulated Radiotherapy ◽  
Tumour Recurrence ◽  
Intensity Modulated ◽  
The World ◽  
Areas Of Concern

AbstractIntensity-modulated radiootherapy (IMRT) is being rapidly embraced as a radiotherapy technique in many cancer centres across the world. This paper aims to highlight the reported problems associated with the use of IMRT for the treatment of head and neck cancer. Specific areas of concern that are mentioned are the identification of tumour volumes, reproducibility of treatment, issues of tumour resistance and tumour recurrence. Radiotherapy departments are advised to make haste slowly when considering the implementation of this technique.

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