scholarly journals Dynamic structural cell responses in the thymus to acute injury, regeneration, and age

2021 ◽  
Author(s):  
Lorenz L Jahn ◽  
Anastasia I Kousa ◽  
Lisa Sikkema ◽  
Angel E Flores ◽  
Kimon V Argyropoulos ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Marrow Transplant ◽  
Cell Development ◽  
Acute Injury ◽  
Thymic Function ◽  
Structural Cell ◽  
Cell Responses ◽  
And Function ◽  
Old Mice

The thymus, the primary site of T cell development, is extremely sensitive to insult but also harbors tremendous capacity for repair. Using single cell sequencing of thymic structural cells, as well as functional and structural analyses, we revealed distinct regenerative programs by endothelial and mesenchymal subsets after injury that stimulated epithelial repair; the compartment primarily supporting T cell development. Thymic function not only declined over lifespan, contributing to immune aging, but the capacity of the thymus to regenerate after damage also declined in old mice. This could be attributed to an inability of the old microenvironment to induce reparative programs; leading to reduced ability to restore tissue structure and function. These findings provide a detailed framework for the response of structural cells to aging and acute damage, which could have considerable implications for our understanding of aging immunity and recovery from treatments such as chemotherapy and bone marrow transplant.

scholarly journals Developing the right tools for the job: Lin28 regulation of early life T cell development and function

FEBS Journal ◽  
2021 ◽  
Author(s):  
Mengqi Dong ◽  
Ève Mallet Gauthier ◽  
Marilaine Fournier ◽  
Heather J. Melichar
Keyword(s):  
T Cell ◽  
Early Life ◽  
T Cell Development ◽  
Cell Development ◽  
The Right ◽  
And Function

scholarly journals CD2ϵ and CD3ξ cytoplasmic domains can independently generate signals for T cell development and function

Immunity ◽  
1995 ◽  
Vol 2 (4) ◽  
pp. 401-411 ◽  
Author(s):  
Yoichl Shlnkal ◽  
Averll Ma ◽  
Hwei-Lang Cheng ◽  
Frederick W. Alt
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Cytoplasmic Domains ◽  
And Function

scholarly journals Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function

2013 ◽  
Vol 43 (12) ◽  
pp. 3355-3360 ◽  
Author(s):  
Gavin I. Ellis ◽  
Lianteng Zhi ◽  
Ravi Akundi ◽  
Hansruedi Büeler ◽  
Francesc Marti
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

The role of Tec family kinases in T cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 119-138 ◽  
Author(s):  
Julie A. Lucas ◽  
Andrew T. Miller ◽  
Luana O. Atherly ◽  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

scholarly journals The CD3ε Proline-Rich Sequence, and Its Interaction with Nck, Is Not Required for T Cell Development and Function

2005 ◽  
Vol 175 (1) ◽  
pp. 270-275 ◽  
Author(s):  
Andrea L. Szymczak ◽  
Creg J. Workman ◽  
Diana Gil ◽  
Smaroula Dilioglou ◽  
Kate M. Vignali ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

scholarly journals Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

Blood ◽  
2006 ◽  
Vol 107 (6) ◽  
pp. 2453-2460 ◽  
Author(s):  
Önder Alpdogan ◽  
Vanessa M. Hubbard ◽  
Odette M. Smith ◽  
Neel Patel ◽  
Sydney Lu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Growth Factor ◽  
Keratinocyte Growth Factor ◽  
Critical Role ◽  
T Cell Development ◽  
Marrow Transplant ◽  
Cell Development ◽  
Allogeneic Bone ◽  
Thymic Regeneration

AbstractKeratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with KGF-/- mice and demonstrated that thymic cellularity and the distribution of thymocyte subsets among KGF-/-, wildtype (WT), and KGF+/- mice were similar. However, KGF-/- mice are more vulnerable to sublethal irradiation (450 cGy), and a significant decrease was found in thymic cellularity after irradiation. Defective thymopoiesis and peripheral T-cell reconstitution were found in KGF-/- recipients of syngeneic or allogeneic bone marrow transplant, but using KGF-/- mice as a donor did not affect T-cell development after transplantation. Despite causing an early developmental block in the thymus, administration of KGF to young and old mice enhanced thymopoiesis. Exogenous KGF also accelerated thymic recovery after irradiation, cyclophosphamide, and dexamethasone treatment. Finally, we found that administering KGF before bone marrow transplantation (BMT) resulted in enhanced thymopoiesis and peripheral T-cell numbers in middle-aged recipients of an allogeneic BM transplant. We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions. (Blood. 2006;107:2453-2460)

scholarly journals Evolutionarily conserved cysteines in the stalk region of CD3‐epsilon are critical for T cell development and function

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Yibing Wang ◽  
Dean Becker ◽  
Tibor Vass ◽  
Janice White ◽  
Philippa Marrack ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Evolutionarily Conserved ◽  
And Function

T-cell development and function – a downunder experience

2000 ◽  
Vol 21 (10) ◽  
pp. 472-474 ◽  
Author(s):  
Richard Boyd ◽  
Ann Chidgey
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function
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