Role of CD3ε-Mediated Signaling in T-Cell Development and Function

2011 ◽  
Vol 31 (1) ◽  
pp. 73-84 ◽  
Author(s):  
Vibhuti P. Dave
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

The role of Tec family kinases in T cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 119-138 ◽  
Author(s):  
Julie A. Lucas ◽  
Andrew T. Miller ◽  
Luana O. Atherly ◽  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

Role of Shc in T-cell development and function

2003 ◽  
Vol 191 (1) ◽  
pp. 183-195 ◽  
Author(s):  
Li Zhang ◽  
Ulrike Lorenz ◽  
Kodi S. Ravichandran
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

Role of Itk in γδ T cell development and function

2008 ◽  
Vol 22 (S2) ◽  
pp. 410-410
Author(s):  
Catherine Chih‐tzu Yin ◽  
Martin Felices ◽  
Yoko Kosaka ◽  
Joonsoo Kang
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Γδ T Cell ◽  
And Function

scholarly journals Differential role of SLP-76 domains in T cell development and function

2002 ◽  
Vol 99 (2) ◽  
pp. 884-889 ◽  
Author(s):  
L. Kumar ◽  
V. Pivniouk ◽  
M. A. de la Fuente ◽  
D. Laouini ◽  
R. S. Geha
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
And Function

The PI3K p110δ controls T-cell development, differentiation and regulation

2007 ◽  
Vol 35 (2) ◽  
pp. 167-171 ◽  
Author(s):  
D.T. Patton ◽  
F. Garçon ◽  
K. Okkenhaug
Keyword(s):  
T Cell ◽  
Cell Function ◽  
T Cell Development ◽  
Cell Development ◽  
Helper T Cells ◽  
Cellular Functions ◽  
Cellular And Humoral Immunity ◽  
And Migration ◽  
And Function

PI3Ks (phosphoinositide 3-kinases) regulate diverse cellular functions such as metabolism, growth, gene expression and migration. The p110δ isoform of PI3K is mainly expressed in cells of the immune system and contributes to cellular and humoral immunity. In the thymus, p110δ and p110γ play complementary roles in regulating the transition through key developmental checkpoints. In addition, p110δ regulates the differentiation of peripheral Th (helper T-cells) towards the Th1 and Th2 lineages. Moreover, p110δ is critical for Treg (regulatory T-cell) function. Here, we review the role of PI3Ks in T-cell development and function.

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