scholarly journals Prospective hippocampus and putamen activations support conditional memory-guided behavior

2019 ◽  
Author(s):  
A. G. Hamm ◽  
Aaron T. Mattfeld
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Concurrent System ◽  
Contextual Cues ◽  
Preceding Stimulus ◽  
Cortical Regions

Memory of past events, in addition to contextual cues, influence conditional behavior. The hippocampus (HPC), medial prefrontal cortex (mPFC), and striatum are important contributors to this process. The mechanisms by which these regions facilitate conditional memory-guided behavior remains unclear. We developed a conditional-associative task in which the correct conditional choice was dependent on the preceding stimulus. We examined activations related to successful conditional behavior and the timing of their contributions. Two distinct networks emerged: (1) a prospective system consisting of the HPC, putamen, mPFC, and other cortical regions, which exhibited increased activation preceding successful conditional decisions; and (2) a concurrent system supported by the caudate, dlPFC, and additional cortical structures that engaged during execution of correct conditional choices. Our findings demonstrate two distinct neurobiological circuits through which memory prospectively biases conditional memory-guided decisions, as well as influence the execution of current choices.

scholarly journals A cortico-hippocampal scaffold for representing and recalling lifelike events

2021 ◽  
Author(s):  
Zachariah M Reagh ◽  
Charan Ranganath
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Real World ◽  
Memory Retrieval ◽  
Temporal Network ◽  
Specific Context ◽  
Pattern Similarity ◽  
Cortical Regions ◽  
Hippocampal Networks ◽  
Event Representations

Real-world events are complex, featuring elements that may be unique to, or shared across, multiple situations. In the present study, we used fMRI to identify how different event components are represented in real-time and during memory retrieval. Twenty participants viewed and recalled eight videos depicting real-world events, combining people, contexts, and context types. Multi-voxel pattern similarity analyses revealed specific person representations, persistent across contexts, in regions of an Anterior-Temporal Network. Conversely, we found specific context representations, persistent across people, in regions of a Posterior-Medial Network. We also found schema-like generalization across contexts in medial prefrontal cortex, and episodic specificity in the hippocampus. Event patterns were reinstated during recall, and hippocampal reinstatement predicted the number of details retrieved. Finally, we observed distinct representational timescales across the hippocampus and cortical regions. These findings reveal mechanisms for scaffolding different aspects of lifelike event representations in cortico-hippocampal networks as experiences are observed and recalled.

The development of perineuronal nets around parvalbumin gabaergic neurons in the medial prefrontal cortex and basolateral amygdala of rats.

2017 ◽  
Vol 131 (4) ◽  
pp. 289-303 ◽  
Author(s):  
Kathryn D. Baker ◽  
Arielle R. Gray ◽  
Rick Richardson
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Basolateral Amygdala ◽  
Gabaergic Neurons ◽  
Perineuronal Nets

Dissociating top-down and bottom-up influences on intentional decisions within the medial prefrontal cortex

2011 ◽  
Author(s):  
J. Demanet ◽  
W. de Baene ◽  
C. C. Arrington ◽  
M. Brass
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Top Down ◽  
Bottom Up
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