scholarly journals Automating the application of smart materials for protein crystallization

2015 ◽  
Vol 71 (3) ◽  
pp. 534-540 ◽  
Author(s):  
Sahir Khurshid ◽  
Lata Govada ◽  
Hazim F. EL-Sharif ◽  
Subrayal M. Reddy ◽  
Naomi E. Chayen

The fabrication and validation of the first semi-liquid nonprotein nucleating agent to be administered automatically to crystallization trials is reported. This research builds upon prior demonstration of the suitability of molecularly imprinted polymers (MIPs; known as `smart materials') for inducing protein crystal growth. Modified MIPs of altered texture suitable for high-throughput trials are demonstrated to improve crystal quality and to increase the probability of success when screening for suitable crystallization conditions. The application of these materials is simple, time-efficient and will provide a potent tool for structural biologists embarking on crystallization trials.

2011 ◽  
Vol 108 (27) ◽  
pp. 11081-11086 ◽  
Author(s):  
E. Saridakis ◽  
S. Khurshid ◽  
L. Govada ◽  
Q. Phan ◽  
D. Hawkins ◽  
...  

2012 ◽  
Vol 13 (12) ◽  
pp. 3959-3965 ◽  
Author(s):  
Subrayal M Reddy ◽  
Quan T Phan ◽  
Hazim El-Sharif ◽  
Lata Govada ◽  
Derek Stevenson ◽  
...  

2010 ◽  
Vol 38 (3) ◽  
pp. 401-404
Author(s):  
Da-Wei LOU ◽  
Ying-Jie YANG ◽  
Guang HUANG ◽  
Ping-Li PU ◽  
Xin-Qing LEE ◽  
...  

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