An Enhanced Neural Network Based on Deep Metric Learning for Skin Lesion Segmentation

Author(s):  
Xinhua Liu ◽  
Gaoqiang Hu ◽  
Xiaolin Ma ◽  
Hailan Kuang
Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 572
Author(s):  
Alan M. Luu ◽  
Jacob R. Leistico ◽  
Tim Miller ◽  
Somang Kim ◽  
Jun S. Song

Understanding the recognition of specific epitopes by cytotoxic T cells is a central problem in immunology. Although predicting binding between peptides and the class I Major Histocompatibility Complex (MHC) has had success, predicting interactions between T cell receptors (TCRs) and MHC class I-peptide complexes (pMHC) remains elusive. This paper utilizes a convolutional neural network model employing deep metric learning and multimodal learning to perform two critical tasks in TCR-epitope binding prediction: identifying the TCRs that bind a given epitope from a TCR repertoire, and identifying the binding epitope of a given TCR from a list of candidate epitopes. Our model can perform both tasks simultaneously and reveals that inconsistent preprocessing of TCR sequences can confound binding prediction. Applying a neural network interpretation method identifies key amino acid sequence patterns and positions within the TCR, important for binding specificity. Contrary to common assumption, known crystal structures of TCR-pMHC complexes show that the predicted salient amino acid positions are not necessarily the closest to the epitopes, implying that physical proximity may not be a good proxy for importance in determining TCR-epitope specificity. Our work thus provides an insight into the learned predictive features of TCR-epitope binding specificity and advances the associated classification tasks.


2020 ◽  
Vol 17 (9) ◽  
pp. 4125-4130
Author(s):  
Gaurav Karkal ◽  
K. Dhanush Reddy ◽  
Kaushik Singh ◽  
Nikith Hosangadi ◽  
Annapurna P. Patil

Standard deep learning in the context of facial recognition involves inputting a single image and outputting a label for that image. Deep metric learning distinguishes itself by outputting a real valued feature vector instead of a single label. The usage of deep metric learning has revolutionised facial recognition, making it very accurate and reliable. This paper exhibits the accuracy and reliability of the facial recognition model using deep metric learning in the application of an automated attendance system. The paper presents a non-intrusive attendance system which uses the described neural network to recognize faces and record attendance. The system uses the pre-trained neural network to generate embeddings for faces, using a method known as the triple training step, which is described in the paper. These embeddings are generated from a collection of photos per person. After the embeddings are generated, the system is ready to perform facial recognition on sample photos. CNN is used for facial detection in the sample group photos. Once the faces are detected, a KNN classifier is used for recognizing faces. Finally after the faces are recognized, the attendance for each recognized student is marked in the database. Thus, the whole process of attendance was automated without the requirement of human interaction.


IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 122811-122825
Author(s):  
Yun Jiang ◽  
Simin Cao ◽  
Shengxin Tao ◽  
Hai Zhang

Author(s):  
Saleh Baghersalimi ◽  
Behzad Bozorgtabar ◽  
Philippe Schmid-Saugeon ◽  
Hazım Kemal Ekenel ◽  
Jean-Philippe Thiran

2019 ◽  
Author(s):  
Muhammad Attique Khan ◽  
Muhammad Imran Sharif ◽  
Mudassar Raza ◽  
Almas Anjum ◽  
Tanzila Saba ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document