Abstract. This study investigates current ground motions derived from the GPS geodesy infrastructure in the Gulf of Mexico region. The positions and velocity vectors of 161 continuous GPS (CGPS) stations are presented with respect to a newly established local reference frame, the Stable Gulf of Mexico Reference Frame (SGOMRF). Thirteen long-term (> 5 years) CGPS are used to realize the local reference frame. The root-mean-square (RMS) of the velocities of the 13 SGOMRF reference stations achieves 0.2 mm yr−1 in the horizontal and 0.3 mm yr−1 in the vertical directions. GPS observations presented in this study indicate significant land subsidence in the coastal area of southeastern Louisiana, the greater Houston metropolitan area, and two cities in Mexico (Aguascalientes and Mexico City). The most rapid subsidence is recorded at the Mexico City International airport, which is up to 26.6 cm yr−1 (2008–2014). Significant spatial variation of subsidence rates is observed in both Mexico City and the Houston area. The overall subsidence rate in the Houston area is decreasing. GPS observations in southeastern Louisiana indicate minor (4.0–6.0 mm yr−1) but consistent subsidence over time and space. This poses a potential threat to the safety of costal infrastructure in the long-term.