QT variability analysis for risk stratification in patients with dilated cardiomyopathy

2014 ◽  
Author(s):  
Claudia Fischer ◽  
Andrea Seeck ◽  
Rico Schroeder ◽  
Matthias Goernig ◽  
Alexander Schirdewan ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Variability Analysis ◽  
Qt Variability

QT variability improves risk stratification in patients with dilated cardiomyopathy

2015 ◽  
Vol 36 (4) ◽  
pp. 699-713 ◽  
Author(s):  
C Fischer ◽  
A Seeck ◽  
R Schroeder ◽  
M Goernig ◽  
A Schirdewan ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Qt Variability

scholarly journals Sudden Cardiac Death in Hereditary Dilated Cardiomyopathy

2020 ◽  
Author(s):  
Marianna Leopoulou ◽  
Jo Ann LeQuang ◽  
Joseph V. Pergolizzi ◽  
Peter Magnusson
Keyword(s):  
Sudden Cardiac Death ◽  
Left Ventricle ◽  
Sudden Death ◽  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Cardiac Death ◽  
Disease Risk ◽  
Systolic Dysfunction ◽  
Preventive Strategies ◽  
Genetic Origin

Dilated cardiomyopathy (DCM) is characterized by the phenotype of a dilated left ventricle with systolic dysfunction. It is classified as hereditary when it is deemed of genetic origin; more than 50 genes are reported to be related to the condition. Symptoms include, among others, dyspnea, fatigue, arrhythmias, and syncope. Unfortunately, sudden cardiac death may be the first manifestation of the disease. Risk stratification regarding sudden death in hereditary DCM as well as preventive management poses a challenge due to the heterogeneity of the disease. The purpose of this chapter is to present the epidemiology, risk stratification, and preventive strategies of sudden cardiac death in hereditary DCM.

scholarly journals Reconsidering arrhythmic risk stratification in dilated cardiomyopathy – Beyond ventricular contractility and gene mutability

2019 ◽  
Vol 60 (3) ◽  
pp. 196-197 ◽  
Author(s):  
Konstantinos A. Gatzoulis ◽  
Emmanuel Kanoupakis ◽  
Christos-Konstantinos Antoniou ◽  
Antonios Sideris ◽  
Theofilos M. Kolettis
Keyword(s):  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Ventricular Contractility

Arrhythmic risk stratification in non-ischemic dilated cardiomyopathy: Where do we stand after DANISH?

2017 ◽  
Vol 27 (8) ◽  
pp. 542-555 ◽  
Author(s):  
Polychronis Dilaveris ◽  
Christos-Konstantinos Antoniou ◽  
Konstantinos A. Gatzoulis
Keyword(s):  
Risk Stratification ◽  
Dilated Cardiomyopathy ◽  
Non Ischemic Dilated Cardiomyopathy

Abstract 2851: Temporal QT Variability from Bipolar Ventricular Tip-to-Ring Electrograms Predicts Sustained Ventricular Tachyarrhythmia.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Larisa G Tereshchenko ◽  
Barry J Fetics ◽  
Peter P Domitrovich ◽  
Ronald D Berger
Keyword(s):  
Risk Stratification ◽  
Right Ventricular ◽  
Effective Means ◽  
Ventricular Tachyarrhythmia ◽  
Icd Implantation ◽  
Area Index ◽  
Icd Therapy ◽  
Increased Risk ◽  
Qt Variability

We assessed the hypothesis that ventricular tachycardia / ventricular fibrillation (VT/VF) risk stratification based on the repolarization assessment of intracardiac electrograms (EGMs) from implantable devices is feasible. Methods: Bipolar right ventricular tip-to-ring EGMs were recorded at rest (mean heart rate 66 ± 16 bpm) for 5.5 ± 2.6 minutes in 75 patients (58 ± 14 years, 72% men) with ischemic (60%) and non-ischemic (40%) cardiomyopathy who underwent single-chamber Medtronic ICD implantation for primary (77%) or secondary (23%) prevention of SCD. QT variability index (QTVI), variability of Tpeak-Tend area index, and T-wave alternans (TWA) were calculated as previously described elsewhere. Only 41 out of 75 recordings (55%) were eligible for analysis as determined by data quality requirements of the custom software (less than 10% non-analyzable beats or 5% ectopic beats). The endpoint was appropriate ICD therapy for VT/VF during follow-up > 6 months. Results: During mean follow-up of 12 months (range 6–19 months), 12 patients had appropriate ICD therapy. The survival analysis showed that the top quartile of QTVI (> - 0.5) predicts an event-free survival rate from appropriate ICD therapies (p = 0.027). Neither increased Tpeak-Tend area variability nor TWA was associated with a significant increased risk for VT/VF. Conclusions: In this prospective study, temporal QT variability measured from right ventricular tip-to-ring EGMs is associated with increased risk of sustained VT/VF events. Repolarization lability may be present throughout the ventricular myocardium, such that single-site EGMs may provide an effective means for VT/VF risk stratification.

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