A gene knockout strategy for succinate production using a hybrid algorithm of bees algorithm and minimization of metabolic adjustment

2014 ◽  
Author(s):  
Ching Lee Koo ◽  
Mohd Saberi Mohamad ◽  
Sigeru Ornatu ◽  
Abdul Hakim Mohamed Salleh ◽  
Safaai Deris ◽  
...  
Keyword(s):  
Hybrid Algorithm ◽  
Gene Knockout ◽  
Bees Algorithm ◽  
Succinate Production ◽  
Metabolic Adjustment ◽  
Minimization Of Metabolic Adjustment

scholarly journals In silico gene knockout prediction using a hybrid of Bat algorithm and minimization of metabolic adjustment

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mei Yen Man ◽  
Mohd Saberi Mohamad ◽  
Yee Wen Choon ◽  
Mohd Arfian Ismail
Keyword(s):  
Metabolic Engineering ◽  
Gene Knockout ◽  
Lactate Production ◽  
Bat Algorithm ◽  
Host Cells ◽  
Knock Out ◽  
Genetic Manipulations ◽  
Microbial Strains ◽  
Metabolic Adjustment ◽  
Minimization Of Metabolic Adjustment

Abstract Microorganisms commonly produce many high-demand industrial products like fuels, food, vitamins, and other chemicals. Microbial strains are the strains of microorganisms, which can be optimized to improve their technological properties through metabolic engineering. Metabolic engineering is the process of overcoming cellular regulation in order to achieve a desired product or to generate a new product that the host cells do not usually need to produce. The prediction of genetic manipulations such as gene knockout is part of metabolic engineering. Gene knockout can be used to optimize the microbial strains, such as to maximize the production rate of chemicals of interest. Metabolic and genetic engineering is important in producing the chemicals of interest as, without them, the product yields of many microorganisms are normally low. As a result, the aim of this paper is to propose a combination of the Bat algorithm and the minimization of metabolic adjustment (BATMOMA) to predict which genes to knock out in order to increase the succinate and lactate production rates in Escherichia coli (E. coli).

A hybrid of ant colony optimization and minimization of metabolic adjustment to improve the production of succinic acid in Escherichia coli

2014 ◽  
Vol 49 ◽  
pp. 74-82 ◽  
Author(s):  
Shiue Kee Chong ◽  
Mohd Saberi Mohamad ◽  
Abdul Hakim Mohamed Salleh ◽  
Yee Wen Choon ◽  
Chuii Khim Chong ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Succinic Acid ◽  
Ant Colony Optimization ◽  
Ant Colony ◽  
Metabolic Adjustment ◽  
Minimization Of Metabolic Adjustment
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