Cloud computing, with superior computing power, low-cost and high-security, will be applied to the resource-sharing area of E-government information with great significance and value. From the point of theory, technology and practice, it is scientifically feasible to build a cloud-based E-government information resource-sharing platform, and some areas are actively building this. This paper, through analysis of the problems existing in Cangzhou E-Government and through the design of the E-government cloud computing model, puts forward new ways to explore the development of regional E-government based on cloud computing.