Hemodynamic Performance In-Vivo of a New Ventricular Assist Device

2005 ◽  
Author(s):  
F. Corona ◽  
E. Sacristan ◽  
R. Barragan ◽  
H. Martinez ◽  
O. Infante ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Assist Device ◽  
Ventricular Assist ◽  
Hemodynamic Performance

In vivo testing of a pulsatile implantable impeller pump as a left ventricular assist device used in calves

Perfusion ◽  
1995 ◽  
Vol 10 (4) ◽  
pp. 257-263 ◽  
Author(s):  
KX Qian ◽  
SS Wang ◽  
SH Chu
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist ◽  
Mean Pressure ◽  
In Vivo Testing ◽  
Serum Glutamic Oxalacetic Transaminase

A pulsatile implantable impeller pump was tested as a left ventricular assist device in five calves. The experiments lasted for 4-11 days. Death or termination was mainly due to respiratory complications or bleeding, irrelevant to the pump itself. As indicators of haemolysis, thrombogenesis, renal and hepatic functions, free haemoglobin( FHb), haematocrit (Hct), platelet number (Plt), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine, serum glutamic oxalacetic transaminase (GOT) and total bilirubin were measured preoperatively, at the beginning of the pumping (pump on), six hours later and every day thereafter. The data indicated that the pump caused no severe blood damage or organ dysfunction. Thus, the feasibility of a pulsatile centrifugal pump was demonstrated. The pump with its driver weighs 110 g and is capable of delivering a blood flow up to 8 l/min against 100 mmHg mean pressure.

In Vivo Evaluation of a Pneumatic Extracorporeal Ventricular Assist Device for up to 90 Day Support

ASAIO Journal ◽  
2016 ◽  
Vol 62 (6) ◽  
pp. 697-703 ◽  
Author(s):  
Jeff L. Conger ◽  
Brian W. Grace ◽  
Kelsey L. Van Noy ◽  
Kelly M. Handy ◽  
Gil G. Costas ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Assist Device ◽  
In Vivo Evaluation ◽  
Ventricular Assist

Design, Development, and First In Vivo Results of an Implantable Ventricular Assist Device, MicroVad

2004 ◽  
Vol 28 (10) ◽  
pp. 904-910 ◽  
Author(s):  
Wolfgang Kerkhoffs ◽  
Oliver Schumacher ◽  
Bart Meyns ◽  
Erik Verbeken ◽  
Veerle Leunens ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Design Development ◽  
Assist Device ◽  
Ventricular Assist

In Vivo Evaluation of an Intrathoracic Ventricular Assist Device

ASAIO Journal ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 123-126 ◽  
Author(s):  
PAUL HENDRY ◽  
ROY G. MASTERS ◽  
MOHEB IBRAHIM ◽  
MICHAEL BOURKE ◽  
MARILYN KEANEY ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Assist Device ◽  
In Vivo Evaluation ◽  
Ventricular Assist

Evolution of an Electrohydraulic Ventricular Assist Device Through In Vivo Testing

ASAIO Journal ◽  
1996 ◽  
Vol 42 (5) ◽  
pp. M350-353 ◽  
Author(s):  
PAUL J. HENDRY ◽  
ROY G. MASTERS ◽  
MARILYN KEANEY ◽  
MICHAEL BOURKE ◽  
TOFY MUSSIVAND ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
Assist Device ◽  
Ventricular Assist ◽  
In Vivo Testing

Finite Element Analysis on Stellite 17mm Tube Valve for Pediatric Ventricular Assist Device

2017 ◽  
Author(s):  
Christopher M. Scheib ◽  
Raymond K. Newswanger ◽  
Allison M. Beese ◽  
Timothy Bowen ◽  
Gregory S. Lewis ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Ventricular Assist Device ◽  
Structural Reliability ◽  
Cobalt Chromium ◽  
Assist Device ◽  
Element Analysis ◽  
Ventricular Assist ◽  
Material Choice

A Stellite 25 17mm tube valve based upon the Björk-Shiley Monostrut (BSM) valve design was developed for use in the Penn State Pediatric Ventricular Assist Device (PVAD) pump [1]. The hook of the valve was designed to hold a Delrin occluding disc in place while allowing the disc to tilt open 70 degrees from the closed position. Unlike common design constraints which remain in the elastic region, the hook experiences plastic deformation twice during the assembly process, making the material choice of Stellite 25 imperative. Stellite 25 is a cobalt-chromium-tungsten-nickel alloy (Co-20Cr-15W-10Ni) belonging to the material family of superalloys which are commonly used for wear-resistant applications exposed to heat, abrasion, and galling [2, 3]. Along with its excellent in vivo corrosion resistance [4], Stellite 25 exhibits high strength and ductility which permit the hook to be plastically deformed during disc installation while remaining below the strain to failure [3, 4]. Together these qualities make Stellite 25 an ideal material choice for the 17mm tube valve application. Predicting the resultant stresses and strains is critical for determining the safety and structural reliability of the Stellite 25 17mm tube valve for the PVAD after assembly. After performing finite element analysis (FEA), the simulation results were validated by deflection experiments and metallurgical investigations.

In Silico Design and In-Vivo Analysis of the Pediaflow™ Pediatric Ventricular Assist Device

2011 ◽  
Author(s):  
Timothy M. Maul ◽  
James F. Antaki ◽  
Jingchun Wu ◽  
Jeongho Kim ◽  
Marina V. Kameneva ◽  
...  
Keyword(s):  
Ventricular Assist Device ◽  
In Silico ◽  
New Technologies ◽  
Circulatory Support ◽  
Test Procedures ◽  
Assist Device ◽  
Ventricular Assist ◽  
Predicting Performance

Mechanical circulatory support for the smallest newborn pediatric patients has historically been limited to extracorporeal membrane oxygenation, which can only provide several days to weeks of full cardiac support; far short of the median waiting time for pediatric heart transplantation of nearly three months [1]. Recently, new technologies have been developed, including the PediaFlow pediatric ventricular assist device, to address this need. The PediaFlow device is a magnetically levitated (mag lev), mixed flow turbodynamic blood pump which has been developed in large part in silico using CFD-based inverse design optimization and closed form rotor dynamics models [2, 3]. Each prototype undergoes a series of in vitro and in vivo tests to verify the accuracy of the simulations in predicting performance and biocompatibility. The overall goal is continued refinement and progress towards an implantable pump that produces 0.3 −1.5 L/min for up to 6 months in pediatric heart failure patients from 5 to 15 kg. We describe here the design principles and test procedures for the first three prototypes as well as the predicted performance for a fourth prototype currently being prepared for testing (Figure 1).

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