Using fast-scan cyclic voltammetry to evaluate striatal dopamine release elicited by subthalamic nucleus stimulation

2009 ◽  
Author(s):  
D.P. Covey ◽  
P.A. Garris
Keyword(s):  
Cyclic Voltammetry ◽  
Subthalamic Nucleus ◽  
Dopamine Release ◽  
Striatal Dopamine ◽  
Fast Scan Cyclic Voltammetry ◽  
Subthalamic Nucleus Stimulation ◽  
Striatal Dopamine Release

Striatal low-threshold spiking interneurons locally gate dopamine during learning

2020 ◽  
Author(s):  
Elizabeth N. Holly ◽  
M. Felicia Davatolhagh ◽  
Rodrigo A. España ◽  
Marc V. Fuccillo
Keyword(s):  
Cyclic Voltammetry ◽  
Dopamine Release ◽  
Striatal Dopamine ◽  
Operant Learning ◽  
Fast Scan Cyclic Voltammetry ◽  
Directed Learning ◽  
Low Threshold ◽  
Dorsomedial Striatum

Low-threshold spiking interneurons (LTSIs) in the dorsomedial striatum are potent modulators of goal-directed learning. Here, we uncover a novel function for LTSIs in locally and directly gating striatal dopamine, using in vitro fast scan cyclic voltammetry as well as in vivo GRAB-DA sensor imaging and pharmacology during operant learning. We demonstrate that LTSIs, acting via GABAB signaling, attenuate dopamine release, thereby serving as local coordinators of striatal plasticity.

scholarly journals Stimulation of the Subthalamic Nucleus in Parkinson's Disease Does Not Produce Striatal Dopamine Release

Neurosurgery ◽  
2005 ◽  
Vol 56 (3) ◽  
pp. E629-E629
Author(s):  
Aviva Abosch ◽  
Shitij Kapur ◽  
Anthony E. Lang ◽  
Doug Hussey ◽  
Elspeth Sime ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Dopamine Release ◽  
Striatal Dopamine ◽  
Striatal Dopamine Release ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document