Overlap regulation for additive overlapping clustering methods

2016 ◽  
Author(s):  
Mohamed Ismail Maiza ◽  
Chiheb-Eddine Ben N'cir ◽  
Nadia Essoussi
Keyword(s):  
Clustering Methods ◽  
Overlapping Clustering

scholarly journals A Density-Based Method for the Identification of Non-Disjoint Clusters With Arbitrary and Non-Spherical Shapes

2021 ◽  
Vol 22 (2) ◽  
Author(s):  
Chiheb Eddine Ben Ncir
Keyword(s):  
Unsupervised Learning ◽  
Clustering Methods ◽  
Clustering Method ◽  
Overlapping Clustering ◽  
Overlapping Clusters ◽  
Data Object ◽  
Complex Shapes ◽  
Important Challenge ◽  
Data Objects

Overlapping clustering is an important challenge in unsupervised learning applications while it allows for each data object to belong to more than one group. Several clustering methods were proposed to deal with this requirement by using several usual clustering approaches. Although the ability of these methods to detect non-disjoint partitioning, they fail when data contain groups with arbitrary and non-spherical shapes. We propose in this work a new density based overlapping clustering method, referred to as OC-DD, which is able to detect overlapping clusters even having non-spherical and complex shapes. The proposed method is based on the density and distances to detect dense regions in data while allowing for some data objects to belong to more than one group.Experiments performed on articial and real multi-labeled datasets have shown the effectiveness of the proposed method compared to the existing ones.

Categorization of Multiple Documents Using Fuzzy Overlapping Clustering Based on Formal Concept Analysis

2020 ◽  
Vol 30 (05) ◽  
pp. 631-647
Author(s):  
Yi-Hui Chen ◽  
Eric Jui-Lin Lu ◽  
Ya-Wen Cheng
Keyword(s):  
Real World ◽  
Formal Concept Analysis ◽  
Information Science ◽  
Clustering Algorithms ◽  
Concept Analysis ◽  
Formal Concept ◽  
Clustering Methods ◽  
Practical Applications ◽  
Overlapping Clustering ◽  
Positive Results

Most clustering algorithms build disjoint clusters. However, clusters might be overlapped because documents may belong to two or more categories in the real world. For example, a paper discussing the Apple Watch may be categorized into either 3C, Fashion, or even Clothing and Shoes. Therefore, overlapping clustering algorithms have been studied such that a resource can be assigned to one or more clusters. Formal Concept Analysis (FCA), which has many practical applications in information science, has been used in disjoin clustering, but has not been studied in overlapping clustering. To make overlapping clustering possible by using FCA, we propose an approach, including two types of transformation. From the experimental results, it shows that the proposed fuzzy overlapping clustering performed more efficiently than existing overlapping clustering methods. The positive results confirm the feasibility of the proposed scheme used in overlapping clustering. Also, it can be used in applications such as recommendation systems.

Molecular Topology and Other Promiscuity Determinants as Predictors of Therapeutic Class - A Theoretical Framework to Guide Drug Repositioning?

2018 ◽  
Vol 18 (13) ◽  
pp. 1110-1122 ◽  
Author(s):  
Juan F. Morales ◽  
Lucas N. Alberca ◽  
Sara Chuguransky ◽  
Mauricio E. Di Ianni ◽  
Alan Talevi ◽  
...  
Keyword(s):  
Molecular Descriptors ◽  
Drug Repositioning ◽  
Drug Repurposing ◽  
Topological Descriptors ◽  
Log P ◽  
Acidity Constant ◽  
Molecular Topology ◽  
Clustering Methods ◽  
Mean Values ◽  
Qsar Models

Much interest has been paid in the last decade on molecular predictors of promiscuity, including molecular weight, log P, molecular complexity, acidity constant and molecular topology, with correlations between promiscuity and those descriptors seemingly being context-dependent. It has been observed that certain therapeutic categories (e.g. mood disorders therapies) display a tendency to include multi-target agents (i.e. selective non-selectivity). Numerous QSAR models based on topological descriptors suggest that the topology of a given drug could be used to infer its therapeutic applications. Here, we have used descriptive statistics to explore the distribution of molecular topology descriptors and other promiscuity predictors across different therapeutic categories. Working with the publicly available ChEMBL database and 14 molecular descriptors, both hierarchical and non-hierchical clustering methods were applied to the descriptors mean values of the therapeutic categories after the refinement of the database (770 drugs grouped into 34 therapeutic categories). On the other hand, another publicly available database (repoDB) was used to retrieve cases of clinically-approved drug repositioning examples that could be classified into the therapeutic categories considered by the aforementioned clusters (111 cases), and the correspondence between the two studies was evaluated. Interestingly, a 3- cluster hierarchical clustering scheme based on only 14 molecular descriptors linked to promiscuity seem to explain up to 82.9% of approved cases of drug repurposing retrieved of repoDB. Therapeutic categories seem to display distinctive molecular patterns, which could be used as a basis for drug screening and drug design campaigns, and to unveil drug repurposing opportunities between particular therapeutic categories.

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