AbstractBuilding on an SEIR-type model of COVID-19 where the infecteds are further divided into symptomatic and asymptomatic, a system incorporating the various possible interventions is formulated. Interventions, also referred to as controls, include transmission reduction (e.g., lockdown, social distancing, barrier gestures); testing/isolation on the exposed, symptomatic and asymptomatic compartments; and medical controls such as enhancing patients’ medical care and increasing bed capacity. By considering the government’s capacity, the best strategies for implementing the controls were obtained using optimal control theory. Results show that, if all the controls are to be used, the more able the government is, the more it should implement transmission reduction, testing, and enhancing patients’ medical care without increasing hospital beds. However, if the government finds it very difficult to implement the controls for economic reasons, the best approach is to increase the hospital beds. Moreover, among the testing/isolation controls, testing/isolation in the exposed compartment is the least needed when there is significant transmission reduction control. Surprisingly, when there is no transmission reduction control, testing/isolation in the exposed should be optimal. Testing/isolation in the exposed could seemingly replace the transmission reduction control to yield a comparable result to that when the transmission reduction control is being implemented.
Modelling Optimal Control of Cholera in Communities Linked by Migration