Effect of NPC1L1 Polymorphism on Warfarin Stable Dose in Chinese Patients Under Heart Valve Replacement Surgery

Author(s):  
Siqing Ma ◽  
Zhiying Luo ◽  
Xinmin Zhou ◽  
Honghao Zhou ◽  
Ling Chen ◽  
...  
2007 ◽  
Vol 83 (6) ◽  
pp. 2066-2072 ◽  
Author(s):  
Zhen-Xiao Jin ◽  
Jing-Jun Zhou ◽  
Mei Xin ◽  
Dao-Rong Peng ◽  
Xi-Ming Wang ◽  
...  

2019 ◽  
Vol 13 (18) ◽  
pp. 1599-1607
Author(s):  
Yide Cao ◽  
Ganyi Chen ◽  
Huangshu Li ◽  
Yafeng Liu ◽  
Zhonghao Tao ◽  
...  

Aim: To assess the relationship between the De Ritis ratio on admission and warfarin sensitivity in the initial 10 days of anticoagulation therapy. Methods: We retrospectively reviewed data from 906 patients who underwent heart valve replacement surgery. Results: A De Ritis ratio of 1.19 was identified as the optimal cutoff according to the ROC curve. Patients with a high De Ritis ratio achieved an international normalized ratio (INR) ≥4 more easily and earlier than those with a low De Ritis ratio in the initial 10 days of warfarin therapy. Multivariate analysis showed that a high De Ritis ratio was an independent predictor of an INR ≥4 (HR: 2.567; p < 0.001). Conclusion: A De Ritis ratio ≥1.19 on admission was significantly associated with an INR ≥4 in the initial 10 days of warfarin therapy among patients underwent heart valve replacement surgery.


2020 ◽  
Vol 21 (16) ◽  
pp. 1169-1178
Author(s):  
Dan Li ◽  
Hong Zhu ◽  
Zhi-Ying Luo ◽  
Yi Chen ◽  
Guo-Bao Song ◽  
...  

Aim: The aim of this study was to investigate whether variability in warfarin stable dose (WSD) could be influenced by vitamin K-related polymorphisms in patients with heart valve replacement. Patients & methods: Twenty-nine vitamin K-related SNPs in 208 patients who initially took warfarin and achieved WSD were genotyped. Results: After conducting conditional analysis for both VKORC1 -1639G>A and CYP2C9*3, LRP1 rs1800139 and LRP1 rs1800154 were significantly associated with WSD (p = 0.007 and p = 0.015, respectively). Multivariate analysis showed that LRP1 rs1800139 accounted for 5.9% WSD variability. Conclusion: Our results suggest that a novel vitamin K-related gene, LRP1, exerts a relevant influence on WSD, independent of VKORC1 -1639G>A and CYP2C9*3.


Author(s):  
Julie M. Aultman ◽  
Emanuela Peshel ◽  
Cyril Harfouche ◽  
Michael S. Firstenberg

2020 ◽  

Background: Patients with mechanical heart valve replacement surgery (MHVRS) should be followed up in terms of prosthetic valve-related and open heart surgery complications. This study aimed to determine the anticoagulant complications in long term in patients with MHVRS. Methods: This retrospective and descriptive study was conducted in a university hospital, İzmir, Turkey. The data were collected from July to December 2019. In total, 73 patients referring for regular check-ups to the hospital with intervals not exceeded more than 90 days, and those who had international normalized ratio (INR) measurements for January-April-July-October 2018 were included in this study. Results: The mean age of the patients was obtained at 58.98±12.89 years, and 53.4% (n=39) of the cases were male. Moreover, the mean follow-up period was estimated at 65.98±28.47 months. According to the results, complications developed in 60 patients (82.2%). The first hospitalized unit was the emergency department. The factors affecting the development of complications after MHVRS were evaluated, and a difference was found regarding gender (X2=6.18, P=0.013), comorbidities (X2=25.58, P=0.018), and monthly referral for regular check-ups to the hospital (X2=5.20, P=0.023). There was no relationship between the INR levels and the development of complications. Furthermore, the results of evaluating the factors affecting the number of hospitalizations after MHVRS revealed that monthly referral to hospital for check-ups (t=3.18, P=0.002) and history of previous valve surgery (Z=201.00, P=0.03) affected the number of hospitalizations. Conclusions: It was observed that patients frequently refer to the emergency department and struggled with various complications. Moreover, it was found that the patients had frequent bleeding and refer to the emergency service repeatedly. Accordingly, there is a need for interventional studies to reduce postoperative complications and provide the therapeutic INR level.


2014 ◽  
Vol 9 (5) ◽  
pp. 224-230 ◽  
Author(s):  
Keith Jackson ◽  
Lindsey Cook ◽  
Mark Jackson ◽  
Rohini Simbodyal ◽  
Kathryn Carver ◽  
...  

2008 ◽  
Vol 23 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Ümit Karadeniz ◽  
Ozcan Erdemli ◽  
Bulent Yamak ◽  
Nurcan Genel ◽  
Ufuk Tutun ◽  
...  

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