Nidogen and Heparan Sulfate Proteoglycan: Detection of Newly Isolated Basement Membrane Components in Normal and Epidermolysis Bullosa Skin

1987 ◽  
Vol 89 (6) ◽  
pp. 547-550 ◽  
Author(s):  
S. Wright Caughman ◽  
Thomas Krieg ◽  
Rupert Timpl ◽  
Helmut Hintner ◽  
Stephen I. Katz
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Epidermolysis Bullosa ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Membrane Components ◽  
Basement Membrane Components

scholarly journals Immunoelectron microscopy of endothelial cells in rat incisor suggests that most basement membrane components are produced by young cells, whereas heparan sulfate proteoglycan is produced by both young and old cells.

1988 ◽  
Vol 36 (7) ◽  
pp. 763-773 ◽  
Author(s):  
I C Murray ◽  
C P Leblond
Keyword(s):  
Endothelial Cells ◽  
Basement Membrane ◽  
Heparan Sulfate ◽  
Collagen Iv ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Incisor Tooth ◽  
Rat Incisor ◽  
Membrane Components ◽  
Basement Membrane Components

When periodontal capillaries of rat incisor tooth were immunostained for four basement membrane components (laminin, collagen IV, fibronectin, heparan sulfate proteoglycan), all four were detected in the secretory organelles of endothelial cells located within 3 mm of the tooth's proximal end, but only the proteoglycan was observed in cells located 4 mm away and beyond (Experiment I). [3H]-Thymidine autoradiography revealed that the endothelial cells located at the tooth's proximal end were young and actively dividing, whereas those located 4 mm or more away were older and generally quiescent (Experiment II). Since immunostaining of a cell's secretory organelles for a given substance indicates production of this substance, the first experiment shows that endothelial cells at the proximal end produce the four basement membrane components. The second experiment discloses that these cells are young. As for the endothelial cells located 4 mm or more beyond the proximal end, the first experiment reveals that they produce only heparan sulfate proteoglycan, while the second shows that they are relatively old. Production of laminin, collagen IV, and fibronectin only by young cells implies that these substances are long-lived and stable components of basement membrane, whereas production of the proteoglycan by both young and old cells implies that it is labile and continually replaced.

scholarly journals Heterogenous distribution of type IV collagen, entactin, heparan sulfate proteoglycan, and laminin among renal basement membranes as demonstrated by quantitative immunocytochemistry.

1989 ◽  
Vol 37 (6) ◽  
pp. 885-897 ◽  
Author(s):  
M Desjardins ◽  
M Bendayan
Keyword(s):  
Heparan Sulfate ◽  
Type Iv Collagen ◽  
Protein A ◽  
Heparan Sulfate Proteoglycan ◽  
Basement Membranes ◽  
Sulfate Proteoglycan ◽  
Type Iv ◽  
Membrane Components ◽  
Convoluted Tubules ◽  
Basement Membrane Components

Type IV collagen, entactin, heparan sulfate proteoglycan, and laminin antigenic sites were revealed on various rat renal basement membranes by use of protein A-gold immunocytochemistry. The basement membranes of the proximal and distal convoluted tubules, those of Bowman's capsule and glomerulus, and the mesangial matrix were labeled for all the antigens but to differing extents. Control experiments confirmed the specificity of these labelings. Quantitative evaluation revealed an important heterogeneity for each antigen among the various basement membranes. This heterogeneity suggests that the basement membrane components must arrange themselves in different ways, possibly to account for differences in functional properties of the various renal structures.

Alterations in the basement membrane (heparan sulfate) proteoglycan in diabetic mice

Diabetes ◽  
1982 ◽  
Vol 31 (2) ◽  
pp. 185-188 ◽  
Author(s):  
D. H. Rohrbach ◽  
J. R. Hassell ◽  
H. K. Kleinman ◽  
G. R. Martin
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan ◽  
Diabetic Mice

scholarly journals Identification of cDNA clones encoding different domains of the basement membrane heparan sulfate proteoglycan.

1988 ◽  
Vol 263 (31) ◽  
pp. 16379-16387 ◽  
Author(s):  
D M Noonan ◽  
E A Horigan ◽  
S R Ledbetter ◽  
G Vogeli ◽  
M Sasaki ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Cdna Clones ◽  
Sulfate Proteoglycan

Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma

2007 ◽  
Vol 38 (10) ◽  
pp. 1508-1515 ◽  
Author(s):  
Enkhjargal Batmunkh ◽  
Péter Tátrai ◽  
Erzsébet Szabó ◽  
Csaba Lódi ◽  
Ágnes Holczbauer ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Sulfate Proteoglycan

Structure of low density heparan sulfate proteoglycan isolated from a mouse tumor basement membrane

1987 ◽  
Vol 197 (2) ◽  
pp. 297-313 ◽  
Author(s):  
Mats Paulsson ◽  
Peter D. Yurchenco ◽  
George C. Ruben ◽  
Jürgen Engel ◽  
Rupert Timpl
Keyword(s):  
Basement Membrane ◽  
Heparan Sulfate ◽  
Heparan Sulfate Proteoglycan ◽  
Mouse Tumor ◽  
Low Density ◽  
Sulfate Proteoglycan
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