Ghrelin receptor antagonism of fentanyl‐induced conditioned place preference, intravenous self‐administration, and dopamine release in the nucleus accumbens in rats

2019 ◽  
Vol 25 (6) ◽  
Author(s):  
Magdalena Sustkova‐Fiserova ◽  
Nina Puskina ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Kamila Syslova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Dopamine Release ◽  
Place Preference ◽  
Self Administration ◽  
Receptor Antagonism ◽  
Ghrelin Receptor

scholarly journals Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats

2021 ◽  
Vol 22 (5) ◽  
pp. 2397
Author(s):  
Chrysostomos Charalambous ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Nina Puskina ◽  
Romana Šlamberová ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Fixed Ratio ◽  
Place Preference ◽  
Self Administration ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Addiction Therapy ◽  
Significant Efficacy ◽  
Lever Pressing

Cannabis/cannabinoids are widely used for recreational and therapy purposes, but their risks are largely disregarded. However, cannabinoid-associated use disorders and dependence are alarmingly increasing and an effective treatment is lacking. Recently, the growth hormone secretagogue receptor (GHSR1A) antagonism was proposed as a promising mechanism for drug addiction therapy. However, the role of GHS-R1A and its endogenous ligand ghrelin in cannabinoid abuse remains unclear. Therefore, the aim of our study was to investigate whether the GHS-R1A antagonist JMV2959 could reduce the tetrahydrocannabinol (THC)-induced conditioned place preference (CPP) and behavioral stimulation, the WIN55,212-2 intravenous self-administration (IVSA), and the tendency to relapse. Following an ongoing WIN55,212-2 self-administration, JMV2959 3 mg/kg was administered intraperitoneally 20 min before three consequent daily 120-min IVSA sessions under a fixed ratio FR1, which significantly reduced the number of the active lever-pressing, the number of infusions, and the cannabinoid intake. Pretreatment with JMV2959 suggested reduction of the WIN55,212-2-seeking/relapse-like behavior tested in rats on the twelfth day of the forced abstinence period. On the contrary, pretreatment with ghrelin significantly increased the cannabinoid IVSA as well as enhanced the relapse-like behavior. Co-administration of ghrelin with JMV2959 abolished/reduced the significant efficacy of the GHS-R1A antagonist in the cannabinoid IVSA. Pretreatment with JMV2959 significantly and dose-dependently reduced the manifestation of THC-induced CPP. The THC-CPP development was reduced after the simultaneous administration of JMV2959 with THC during conditioning. JMV2959 also significantly reduced the THC-induced behavioral stimulation in the LABORAS cage. Our findings suggest that GHS-R1A importantly participates in the rewarding/reinforcing effects of cannabinoids.

Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats

2017 ◽  
Vol 110 ◽  
pp. 101-113 ◽  
Author(s):  
Pavel Jerabek ◽  
Tereza Havlickova ◽  
Nina Puskina ◽  
Chrysostomos Charalambous ◽  
Marek Lapka ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Receptor Antagonism ◽  
Ghrelin Receptor

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release

2019 ◽  
Vol 26 (1) ◽  
Author(s):  
Macarena F. Gárate‐Pérez ◽  
Alejandra Méndez ◽  
Carolina Bahamondes ◽  
Claudia Sanhueza ◽  
Fanny Guzmán ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Dopamine Release ◽  
Place Preference ◽  
Lateral Septum

Food restriction modulates amphetamine-conditioned place preference and nucleus accumbens dopamine release in the rat

Synapse ◽  
2002 ◽  
Vol 46 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Garret D. Stuber ◽  
Scott B. Evans ◽  
Michael S. Higgins ◽  
Yanping Pu ◽  
Dianne P. Figlewicz
Keyword(s):  
Nucleus Accumbens ◽  
Conditioned Place Preference ◽  
Food Restriction ◽  
Dopamine Release ◽  
Place Preference

scholarly journals Ghrelin Receptor Antagonism of Methamphetamine-Induced Conditioned Place Preference and Intravenous Self-Administration in Rats

2018 ◽  
Vol 19 (10) ◽  
pp. 2925 ◽  
Author(s):  
Tereza Havlickova ◽  
Chrysostomos Charalambous ◽  
Marek Lapka ◽  
Nina Puskina ◽  
Pavel Jerabek ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Addiction Treatment ◽  
Fixed Ratio ◽  
Place Preference ◽  
Self Administration ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Conditioning Period ◽  
Significant Burden

Methamphetamine abuse imposes a significant burden on individuals and society worldwide, and an effective therapy of methamphetamine addiction would provide distinguished social benefits. Ghrelin significantly participates in reinforcing neurobiological mechanisms of stimulants, including amphetamines; thus, ghrelin antagonism is proposed as a promising addiction treatment. The aim of our study was to elucidate whether the pretreatment with growth hormone secretagogue receptor (GHS-R1A) antagonist, substance JMV2959, could reduce the methamphetamine intravenous self-administration (IVSA) and the tendency to relapse, and whether JMV2959 could reduce or prevent methamphetamine-induced conditioned place preference (CPP) in rats. Following an adequate maintenance period, JMV2959 3 mg/kg was administered intraperitoneally 20 min before three consequent daily 180 min sessions of methamphetamine IVSA under a fixed ratio FR1, which significantly reduced the number of active lever-pressings, the number of infusions, and the amount of the consumed methamphetamine dose. Pretreatment with JMV2959 also reduced or prevented relapse-like behavior tested in rats on the 12th day of the abstinence period. Pretreatment with JMV2959 significantly reduced the expression of methamphetamine-induced CPP. Simultaneous administration of JMV2959 with methamphetamine during the conditioning period significantly reduced the methamphetamine-CPP. Our results encourage further research of the ghrelin antagonism as a potential new pharmacological tool for methamphetamine addiction treatment.

scholarly journals Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice

2021 ◽  
Vol 22 (15) ◽  
pp. 8304
Author(s):  
Laia Alegre-Zurano ◽  
Raúl López-Arnau ◽  
Miguel Á. Luján ◽  
Jordi Camarasa ◽  
Olga Valverde
Keyword(s):  
Conditioned Place Preference ◽  
Learning Task ◽  
Place Preference ◽  
Bath Salts ◽  
Self Administration ◽  
Preclinical Research ◽  
Plus Maze ◽  
Life Threatening ◽  
Synthetic Cathinone ◽  
High Responders

3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the “bath salts”. Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigms. In addition, we assessed the effects of the co-administration of CBD and MDPV (3 and 4 mg/kg) on anxiety-like behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Furthermore, CBD exerted anxiolytic-like effects, exclusively in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice varies depending on the requirements of the learning task, resulting in a complex response. Therefore, further research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed.

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