scholarly journals Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference

2010 ◽  
Vol 211 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Elisabet Jerlhag ◽  
Emil Egecioglu ◽  
Suzanne L. Dickson ◽  
Jörgen A. Engel
Keyword(s):  
Conditioned Place Preference ◽  
Dopamine Release ◽  
Place Preference ◽  
Receptor Antagonism ◽  
Ghrelin Receptor ◽  
Locomotor Stimulation

Ghrelin receptor antagonism of morphine-induced conditioned place preference and behavioral and accumbens dopaminergic sensitization in rats

2017 ◽  
Vol 110 ◽  
pp. 101-113 ◽  
Author(s):  
Pavel Jerabek ◽  
Tereza Havlickova ◽  
Nina Puskina ◽  
Chrysostomos Charalambous ◽  
Marek Lapka ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Place Preference ◽  
Receptor Antagonism ◽  
Ghrelin Receptor

scholarly journals Cannabinoid-Induced Conditioned Place Preference, Intravenous Self-Administration, and Behavioral Stimulation Influenced by Ghrelin Receptor Antagonism in Rats

2021 ◽  
Vol 22 (5) ◽  
pp. 2397
Author(s):  
Chrysostomos Charalambous ◽  
Tereza Havlickova ◽  
Marek Lapka ◽  
Nina Puskina ◽  
Romana Šlamberová ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Fixed Ratio ◽  
Place Preference ◽  
Self Administration ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Ghrelin Receptor ◽  
Addiction Therapy ◽  
Significant Efficacy ◽  
Lever Pressing

Cannabis/cannabinoids are widely used for recreational and therapy purposes, but their risks are largely disregarded. However, cannabinoid-associated use disorders and dependence are alarmingly increasing and an effective treatment is lacking. Recently, the growth hormone secretagogue receptor (GHSR1A) antagonism was proposed as a promising mechanism for drug addiction therapy. However, the role of GHS-R1A and its endogenous ligand ghrelin in cannabinoid abuse remains unclear. Therefore, the aim of our study was to investigate whether the GHS-R1A antagonist JMV2959 could reduce the tetrahydrocannabinol (THC)-induced conditioned place preference (CPP) and behavioral stimulation, the WIN55,212-2 intravenous self-administration (IVSA), and the tendency to relapse. Following an ongoing WIN55,212-2 self-administration, JMV2959 3 mg/kg was administered intraperitoneally 20 min before three consequent daily 120-min IVSA sessions under a fixed ratio FR1, which significantly reduced the number of the active lever-pressing, the number of infusions, and the cannabinoid intake. Pretreatment with JMV2959 suggested reduction of the WIN55,212-2-seeking/relapse-like behavior tested in rats on the twelfth day of the forced abstinence period. On the contrary, pretreatment with ghrelin significantly increased the cannabinoid IVSA as well as enhanced the relapse-like behavior. Co-administration of ghrelin with JMV2959 abolished/reduced the significant efficacy of the GHS-R1A antagonist in the cannabinoid IVSA. Pretreatment with JMV2959 significantly and dose-dependently reduced the manifestation of THC-induced CPP. The THC-CPP development was reduced after the simultaneous administration of JMV2959 with THC during conditioning. JMV2959 also significantly reduced the THC-induced behavioral stimulation in the LABORAS cage. Our findings suggest that GHS-R1A importantly participates in the rewarding/reinforcing effects of cannabinoids.

Ghrelin receptor antagonism of morphine-induced accumbens dopamine release and behavioral stimulation in rats

2014 ◽  
Vol 231 (14) ◽  
pp. 2899-2908 ◽  
Author(s):  
Magdalena Sustkova-Fiserova ◽  
Pavel Jerabek ◽  
Tereza Havlickova ◽  
Petr Kacer ◽  
Miloslav Krsiak
Keyword(s):  
Dopamine Release ◽  
Receptor Antagonism ◽  
Ghrelin Receptor
Sign in / Sign up

Export Citation Format

Share Document