Modulation of dopamine release by ethanol is mediated by atypical GABA A receptors on cholinergic interneurons in the nucleus accumbens

2021 ◽  
Author(s):  
Jordan T. Yorgason ◽  
Hillary A. Wadsworth ◽  
Elizabeth J. Anderson ◽  
Benjamin M. Williams ◽  
James N. Brundage ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Gaba A ◽  
Cholinergic Interneurons

scholarly journals Cholinergic Interneurons Underlie Spontaneous Dopamine Release in Nucleus Accumbens

2017 ◽  
Vol 37 (8) ◽  
pp. 2086-2096 ◽  
Author(s):  
Jordan T. Yorgason ◽  
Douglas M. Zeppenfeld ◽  
John T. Williams
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Cholinergic Interneurons

scholarly journals Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Paul F Kramer ◽  
Emily L Twedell ◽  
Jung Hoon Shin ◽  
Renshu Zhang ◽  
Zayd M Khaliq
Keyword(s):  
Dopamine Release ◽  
Branching Processes ◽  
Striatal Dopamine ◽  
Gaba A ◽  
Cholinergic Interneurons ◽  
Adult Mice ◽  
Receptor Modulation ◽  
Channel Inactivation ◽  
Mechanism Of Inhibition ◽  
Striatal Dopamine Release

Axons of dopaminergic neurons innervate the striatum where they contribute to movement and reinforcement learning. Past work has shown that striatal GABA tonically inhibits dopamine release, but whether GABA-A receptors directly modulate transmission or act indirectly through circuit elements is unresolved. Here, we use whole-cell and perforated-patch recordings to test for GABA-A receptors on the main dopaminergic neuron axons and branching processes within the striatum of adult mice. Application of GABA depolarized axons, but also decreased the amplitude of axonal spikes, limited propagation and reduced striatal dopamine release. The mechanism of inhibition involved sodium channel inactivation and shunting. Lastly, we show the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminergic axons and directly inhibited release, but also likely acts by reducing excitation from cholinergic interneurons. Thus, we reveal the mechanisms of GABA-A receptor modulation of dopamine release and provide new insights into the actions of benzodiazepines within the striatum.

scholarly journals Axonal mechanisms mediating GABA-A receptor inhibition of striatal dopamine release

2020 ◽  
Author(s):  
Paul F. Kramer ◽  
Emily L. Twedell ◽  
Jung Hoon Shin ◽  
Renshu Zhang ◽  
Zayd M. Khaliq
Keyword(s):  
Dopaminergic Neuron ◽  
Dopamine Release ◽  
Branching Processes ◽  
Striatal Dopamine ◽  
Gaba A ◽  
Cholinergic Interneurons ◽  
Receptor Modulation ◽  
Mechanism Of Inhibition ◽  
Midbrain Dopaminergic Neurons ◽  
Striatal Dopamine Release

AbstractAxons of midbrain dopaminergic neurons innervate the striatum where they contribute to movement and reinforcement learning. Past work has shown that striatal GABA tonically inhibits dopamine release, but whether GABA-A receptors directly modulate transmission or act indirectly through circuit elements is unresolved. Here, we use whole-cell and perforated-patch recordings to test for GABA-A receptors on the main dopaminergic neuron axons and branching processes within striatum. Application of GABA depolarized axons, but also decreased the amplitude of axonal spikes, limited propagation and reduced striatal dopamine release. The mechanism of inhibition involved sodium channel inactivation and shunting. Lastly, we show that the positive allosteric modulator diazepam enhanced GABA-A currents on dopaminergic neuron axons and directly inhibited release, but also likely acts by reducing excitatory drive from cholinergic interneurons. Thus, we reveal the mechanisms of GABA-A receptor modulation of dopamine release and provide new insight into the actions of benzodiazepines within the striatum.

scholarly journals A pain-induced tonic hypodopaminergic state augments phasic dopamine release in the nucleus accumbens

Pain ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Taylor A. Gee ◽  
Nathan C. Weintraub ◽  
Dong Lu ◽  
Caroline E. Phelps ◽  
Edita Navratilova ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release

β-Amyloid and Lithium Affect the Magnitude of Phasic Dopamine Release in the Shell of the Nucleus Accumbens

2021 ◽  
Vol 51 (2) ◽  
pp. 201-208
Author(s):  
V. N. Mukhin ◽  
I. R. Borovets ◽  
V. V. Sizov ◽  
K. I. Pavlov ◽  
V. M. Klimenko
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Β Amyloid

scholarly journals Stimulation-Evoked Dopamine Release in the Nucleus Accumbens Following Cocaine Administration in Rats Perinatally Exposed to Polychlorinated Biphenyls

2013 ◽  
Vol 136 (1) ◽  
pp. 144-153 ◽  
Author(s):  
Jenna R. Fielding ◽  
Tiffany D. Rogers ◽  
Abby E. Meyer ◽  
Mellessa M. Miller ◽  
Jenna L. Nelms ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Polychlorinated Biphenyls ◽  
Dopamine Release ◽  
Cocaine Administration
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