The Prognostic Value of Kidney Transplant Center Report Cards

Introduction: Living donor kidney transplant (LDKT) is one of the best therapeutic options for end-stage kidney disease (ESKD). Guidelines identify different estimated glomerular filtration rate (eGFR) thresholds to determine the eligibility of donors. The aim of our study was to evaluate whether pretransplant donor eGFR was associated with kidney function in the recipient. Methods: We retrospectively studied LDKT recipients who received a kidney graft between September 1, 2005, and June 30, 2016 in the same transplant center in France and that had eGFR data available at 3, 12, 24, and 36 months posttransplant. Results: We studied 90 donor-recipient pairs. The average age at time of transplant was 51.47 ± 10.95 for donors and 43.04 ± 13.52 years for recipients. Donors’ average eGFR was 91.99 ± 15.37 mL/min/1.73 m2. Donor’s age and eGFR were significantly correlated (p < 0.0001, r2 0.023). Donor’s age and eGFR significantly correlated with recipient’s eGFR at 3, 12, and 24 months posttransplant (age: p < 0.001 at all intervals; eGFR p = 0.001, 0.003, and 0.016, respectively); at 36 months, only donor’s age significantly correlated with recipient’s eGFR. BMI, gender match, and year of kidney transplant did not correlate with graft function. In the multivariable analyses, donor’s eGFR and donor’s age were found to be associated with graft function; correlation with eGFR was lost at 36 months; and donor’s age retained a strong correlation with graft function at all intervals (p < 0.001). Conclusions: Donor’s eGFR and age are strong predictors of recipient’s kidney function at 3 years. We suggest that donor’s eGFR should be clinically balanced with other determinants of kidney function and in particular with age.

Download Full-text

POS-738 SARS-CoV-2 INFECTION IN PEDIATRIC KIDNEY TRANSPLANT RECIPIENTS DURING EARLY AND LATE POST-TRANSPLANT PERIOD: A SINGLE-CENTER REPORT OF 2 CASES

Kidney International Reports ◽

10.1016/j.ekir.2021.03.770 ◽

2021 ◽

Vol 6 (4) ◽

pp. S321-S322

Author(s):

V. KARAVA ◽

A. Kondou ◽

I. Dotis ◽

G. Miserlis ◽

N. Antoniadis ◽

...

Keyword(s):

Kidney Transplant ◽

Transplant Recipients ◽

Single Center ◽

Kidney Transplant Recipients ◽

Post Transplant ◽

Center Report

Download Full-text

Biopsy‐proven calciphylaxis in the Irish National Kidney Transplant Center 2010–2019

International Journal of Dermatology ◽

10.1111/ijd.15516 ◽

2021 ◽

Author(s):

Ciara O'Keeffe ◽

Elsa Barbosa ◽

Marina O'Kane

Keyword(s):

Kidney Transplant ◽

Transplant Center

Download Full-text

Local Variation in Inclusion on Kidney Transplant Waiting Lists: Analysis in the Reference Area of a Kidney Transplant Center

Transplantation Proceedings ◽

10.1016/j.transproceed.2017.09.068 ◽

2018 ◽

Vol 50 (2) ◽

pp. 550-552 ◽

Cited By ~ 1

Author(s):

N.G. Toapanta Gaibor ◽

G. Bernal Blanco ◽

M. Cintra Cabrera ◽

A. Suarez Benjumea ◽

M.A. Pérez Valdivia ◽

...

Keyword(s):

Kidney Transplant ◽

Local Variation ◽

Waiting Lists ◽

Reference Area ◽

Transplant Center

Download Full-text

Antibiotic Sensitivity and Resistance Among the Most Common Uropathogens in Kidney Transplant Recipients

BANTAO Journal ◽

10.2478/bj-2014-0006 ◽

2015 ◽

Vol 12 (1) ◽

pp. 27-32

Author(s):

Borelli Zlatkov ◽

Jean Filipov ◽

Emil Paskalev ◽

Boyka Markova ◽

Yuliya Marteva-Proevska ◽

...

Keyword(s):

Antibiotic Resistance ◽

Kidney Transplant ◽

Antibiotic Sensitivity ◽

High Sensitivity ◽

Transplant Recipients ◽

Kidney Transplant Recipients ◽

Bacterial Strains ◽

Gram Positive ◽

Transplant Center ◽

Enterococcus Spp

Abstract Introduction. Urinary tract infection (UTI) among kidney transplant recipients (KTRs) is one of the most common complications after transplantation. The aim of our study was to analyze the antibiotic sensitivity and resistance of the most common agents causing UTI in Bulgarian KTRs followed up in our Transplant Center. Methods. We analyzed the antibiotic resistance and sensitivity of the most common strains of bacteria causing UTI in the Bulgarian KTRs, namely class Enterobac-teriaceae and Enterococcus spp. We used conventional biochemical methods to identify different strains of uro-pathogens-miniApi (bioMerieux, France) and BBL Crystal (BD). The antibiotic sensitivity was determined via disc-diffusing method, according to the accepted Bulgarian CLSI standard. We used WHONET, version 5.6 to analyze the antibiotic resistance data. Results. The total number of tested patients was 366 [males 228, females 138]. The total number of tested urine samples was 829 [positive ones-203), negative samples 606, contaminated 20]. The most commonly detected uropathogens in Bulgarian KTRs were Gram /-/ negative bacteria (63.80%). Of these, 93.28% belonged to the Enterobacteriaceae group, with E. coli, K. pneumoniae and the PPM /Proteus, Providentia, Mor-ganela/subgroup being the most common (54.5%, 19.20% and 16%, respectively). Gram /+/ positive bacteria were detected in 28.09% of the patients, Enterococcus spp being the most commonly isola-ted-67.79%. In the Enterococcus group, the strains of E. faecalis and E. faecium were the most commonly detected. The bacteria belonging to Enterobacteriaceae group were most sensitive to carbapenems and aminoglycosides, with sensitivity peaking to almost 100%, whereas they were least sensitive to aminopenicillines [sensitivity below 20%]. The PPM subgroup revealed very high sensitivity to beta-lactamase protected broad spectrum penicillins (Piperacillin/Tazobactam, sensitivity - 90%). Gram /+/ positive uropathogens were mostly sensitive to Linezolid, Vancomycin, Teicoplanin (100%). These strains were least sensitive to Erythromycin and Tetracicline (17.50%). Conclusions. Our results were similar to previous studies. The differences detected can be explained with the characteristics of the bacterial strains and the specific practice of each transplant center. Having in mind the possible complications of UTIs, further studies are needed to clarify the problem with antimicrobial resistance in uropathogens and the use of antibiotics after KT.

Download Full-text