Rectification of cavernosal fibrosis and veno‐occlusive dysfunction by administration of suberoylanilide hydroxamic acid in a rat model of cavernosal nerve injury: Comparison with a PDE5 inhibitor

Andrology ◽  
2020 ◽  
Author(s):  
Min Chul Cho ◽  
Junghoon Lee ◽  
Hwancheol Son ◽  
Soo Woong Kim
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Hydroxamic Acid ◽  
Pde5 Inhibitor ◽  
Suberoylanilide Hydroxamic Acid ◽  
Cavernosal Nerve

164 The Effects of Multiple Adipose-Derived Stem Cell Intracorporeal Injections on Erectile Dysfunction in a Rat Model of Cavernosal Nerve Injury

2018 ◽  
Vol 15 (2) ◽  
pp. S48-S49
Author(s):  
J. Anaissie ◽  
N.M. Haney ◽  
B. Song ◽  
Z. Brabadi ◽  
T. Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Rat Model ◽  
Adipose Derived Stem Cell ◽  
Cavernosal Nerve

scholarly journals The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Dogan Atilgan ◽  
Bekir S. Parlaktas ◽  
Nihat Uluocak ◽  
Fikret Erdemir ◽  
Fatma Markoc ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oxidative Damage ◽  
Nerve Injury ◽  
Rat Model ◽  
Protein Carbonyl ◽  
Control Group ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Collagen Density ◽  
Cavernosal Nerve

Aim. The aim of this study was to compare the effects of sildenafil and trimetazidine on bilateral cavernosal nerve injury-induced oxidative damage and fibrotic changes in cavernosal tissue in rat model.Material and Methods. A total of 32 male Sprague-Dawley rats were randomly divided into 4 groups; each group consist 8 rats (control, BCI, BCI + TMZ, and BCI + sildenafil groups). Tissue superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) levels were determined biochemically and distribution of cavernosal fibrosis density among groups was performed histopathologically.Results. Tissue SOD levels in BCI group were significantly lower than the control group (P<0.05). Tissue MDA and PC levels in BCI group were significantly higher than the control group (P<0.05). TMZ and sildenafil administration significantly increased tissue SOD levels (P<0.05) and reduced tissue MDA and PC levels (P<0.05). Histologically, the degree of cavernosal fibrosis and collagen density was higher in BCI group in comparison to control, TMZ-treated, and sildenafil-treated groups.Conclusion. BCI caused oxidative damage and increased cavernosal fibrosis in rat penis. TMZ and sildenafil treatment decreased oxidative damage and reduced the degree of fibrosis in penile tissue due to BCI.

scholarly journals Transpelvic Magnetic Stimulation Enhances Penile Microvascular Perfusion in a Rat Model: A Novel Interventional Strategy to Prevent Penile Fibrosis after Cavernosal Nerve Injury

2022 ◽  
Vol 40 ◽  
Author(s):  
Samuel Sorkhi ◽  
Christopher Cano Sanchez ◽  
Min Chul Cho ◽  
Sung Yong Cho ◽  
Hong Chung ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Magnetic Stimulation ◽  
Microvascular Perfusion ◽  
Cavernosal Nerve

scholarly journals PD31-12 THE EFFECTS OF MULTIPLE ADIPOSE-DERIVED STEM CELL INTRACORPOREAL INJECTIONS ON ERECTILE DYSFUNCTION IN A RAT MODEL OF CAVERNOSAL NERVE INJURY

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
James Anaissie ◽  
Nora Haney ◽  
Bryant Song ◽  
Zara Barabadi ◽  
Andrew Sholl ◽  
...  
Keyword(s):  
Stem Cell ◽  
Erectile Dysfunction ◽  
Nerve Injury ◽  
Rat Model ◽  
Adipose Derived Stem Cell ◽  
Cavernosal Nerve

scholarly journals MP59-09 A STRATEGY FOR RESTORATION OF ERECTILE FUNCTION BY A COMBINATION OF ANTI-FIBROTIC EFFECT BY LIM-KINASE 2 INHIBITOR WITH SUPPRESSION OF APOPTOSIS BY JNK INHIBITOR IN A RAT MODEL OF CAVERNOSAL NERVE INJURY

2019 ◽  
Vol 201 (Supplement 4) ◽  
Author(s):  
Junghoon Lee* ◽  
Seung-EE Kim ◽  
Young Cheol Hwang ◽  
Sangjun Yoo ◽  
Sang Jun Chun ◽  
...  
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Erectile Function ◽  
Lim Kinase ◽  
Cavernosal Nerve
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