A unique case of splenic rupture secondary to vaccine‐induced immune thrombocytopenia managed with splenic embolization

Though rare, atraumatic rupture of the spleen can be a complication in certain leukaemias and lymphomas. We present a unique case of atraumatic rupture of the spleen in a patient with chronic lymphocytic leukaemia. The patient presented to the emergency department with abdominal pain; he had been on ibrutinib therapy but stopped taking the medication abruptly 6 days prior. On evaluation, he was found to have a ruptured spleen with a haemoperitoneum. Pathology of the excised spleen showed infiltration of the spleen with hyperproliferated CD5+ intermediate-to-large cells, consistent with B-cell lymphoma and favouring Richter’s transformation. There are only a few available reports of patients with similar presentations identified in our literature review.

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Littoral cell angioma with splenic rupture in pregnancy

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2017-0064 ◽

2018 ◽

Vol 7 (1) ◽

Author(s):

Ann McHugh ◽

Catherine O’Gorman ◽

Sharon Cooley ◽

Gerry McEntee ◽

Naomi Burke

Keyword(s):

Splenic Rupture ◽

Rare Event ◽

Vascular Tumour ◽

Third Trimester ◽

Unique Case ◽

Littoral Cell ◽

Littoral Cell Angioma ◽

Splenic Red Pulp ◽

In Pregnancy ◽

Red Pulp

Abstract Splenic rupture in pregnancy is a rare event. It is generally due to trauma or an underlying splenic pathology. Timely diagnosis and intervention of splenic rupture is essential given the high rates of associated maternal and fetal morbidity and mortality. This case illustrates a 38 year old lady in the third trimester of pregnancy who presented with maternal collapse and a non-reassuring foetal heart rate tracing following a fall at home one week previously. A massive hemoperitoneum was identified at caesarean section and a splenectomy was performed. Histological examination revealed a littoral cell angioma of the spleen. This vascular tumour arising in the splenic red pulp sinuses is a rare entity and specific immunophenotypic features help distinguish it from other vascular tumours of the spleen. Both trauma and an underlying splenic pathology led to splenic rupture in this unique case.

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Partial Splenic Embolization in Myelodysplastic Syndrome Associated with Immune Thrombocytopenia

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-005-0349-2 ◽

2004 ◽

Vol 18 (3) ◽

pp. 213-216 ◽

Cited By ~ 1

Author(s):

Hakan Ozdogu ◽

Can Boga ◽

Levent Oğuzkurt ◽

Ebru Kı zı lkı lı c

Keyword(s):

Myelodysplastic Syndrome ◽

Immune Thrombocytopenia ◽

Partial Splenic Embolization ◽

Splenic Embolization

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A SURVIVAL CASE OF SPONTANEOUS SPLENIC RUPTURE DUE TO LEUKOCYTOSIS MANAGED SUCCESSFULLY BY SELECTIVE SPLENIC EMBOLIZATION

Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) ◽

10.3919/jjsa.69.913 ◽

2008 ◽

Vol 69 (4) ◽

pp. 913-916 ◽

Cited By ~ 3

Author(s):

Takashi SEKI ◽

Kiyoshi HIRAMATSU ◽

Takaaki ITO ◽

Yuichi MACHIKI ◽

Tadayuki SAKURAGAWA ◽

...

Keyword(s):

Splenic Rupture ◽

Spontaneous Splenic Rupture ◽

Splenic Embolization ◽

Survival Case

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Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient

Case Reports in Hematology ◽

10.1155/2019/1425151 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Ryan A. Denu ◽

Daniel R. Matson ◽

Matthew J. Davis ◽

Natalie J. Tedford ◽

Christine E. Brichta ◽

...

Keyword(s):

Immune Thrombocytopenia ◽

Hematologic Malignancy ◽

Hematologic Malignancies ◽

Lymphoblastic Lymphoma ◽

Behavior Changes ◽

High Dose ◽

Unique Case ◽

Chronic Itp ◽

Unclear Etiology ◽

T Lymphoblastic Lymphoma

Immune thrombocytopenia (ITP) is characterized by isolated thrombocytopenia of unclear etiology. We present a unique case of an 8-year-old girl with chronic ITP who was subsequently diagnosed with T-lymphoblastic lymphoma at age 11. The clinical course was complicated by the occurrence of nonepileptiform events with bizarre behavior changes following the administration of nelarabine and intrathecal and high-dose systemic methotrexate. This case highlights an unusual co-occurrence of hematologic malignancy and chronic ITP in an otherwise healthy child. We speculate that underlying genetic or immunologic lesions may predispose a subset of pediatric ITP patients to the development of hematologic malignancies.

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