Complement activation by dialysis membranes and its association with secondary membrane formation and surface charge

2020 ◽  
Author(s):  
Pascal Melchior ◽  
Ansgar Erlenkötter ◽  
Adam M Zawada ◽  
Dirk Delinski ◽  
Christian Schall ◽  
...  
Keyword(s):  
Surface Charge ◽  
Complement Activation ◽  
Membrane Formation ◽  
Dialysis Membranes ◽  
Secondary Membrane

scholarly journals MO676COMPLEMENT ACTIVATION BY DIALYSIS MEMBRANES AND ITS ASSOCIATION WITH SECONDARY MEMBRANE FORMATION AND SURFACE CHARGE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Pascal Melchior ◽  
Ansgar Erlenkötter ◽  
Adam Zawada ◽  
Dirk Delinski ◽  
Christian Schall ◽  
...  
Keyword(s):  
Zeta Potential ◽  
Surface Charge ◽  
Complement Activation ◽  
Ex Vivo ◽  
Polysulfone Membrane ◽  
Membrane Formation ◽  
Sieving Coefficient ◽  
Recirculation Model ◽  
Dialysis Membranes ◽  
Secondary Membrane

Abstract Background and Aims Activation of the complement system may occur during blood-membrane interactions in hemodialysis and contribute to chronic inflammation of patients with end-stage renal disease (ESRD). Hydrophilic modification with polyvinylpyrrolidone (PVP) has been suggested to increase the biocompatibility profile of dialysis membranes. In the present study we compared complement activation of synthetic and cellulose-based membranes, including the polysulfone membrane with α-tocopherol-stabilized, PVP-enriched inner surface of the novel FX CorAL dialyzer, and linked the results to their physical characteristics. Method Eight synthetic and cellulose-based dialyzers (FX CorAL, FX CorDiax [Fresenius Medical Care]; Polyflux, THERANOVA [Baxter]; ELISIO, SUREFLUX [Nipro]; xevonta [B. Braun]; FDX [Nikkisio Medical]) were investigated in the present study. Complement activation (C3a, C5a, sC5b-9) was evaluated in a 3h ex vivo recirculation model with human blood. Albumin sieving coefficients were determined over a 4h ex vivo recirculation model with human plasma as a surrogate of secondary membrane formation. Zeta potential was measured as an indicator for the surface charge of the membranes. Results The FX CorAL dialyzer induced the lowest activation of the three complement factors (C3a: -39.4%; C5a: -57.5%; sC5b-9: -58.9% compared to the reference). Highest complement activation was found for the cellulose-based SUREFLUX (C3a: +154.0%) and the FDX (C5a: +335.0%; sC5b-9: +287.9%) dialyzers. Moreover, the FX CorAL dialyzer had the nearest-to-neutral zeta potential (-2.38 mV) and the lowest albumin sieving coefficient decrease over time. Albumin sieving coefficient decrease was associated with complement activation by the investigated dialyzers. Conclusion Our present results indicate that the surface modification implemented in the FX CorAL dialyzer reduces secondary membrane formation and improves the biocompatibility profile. Further clinical studies are needed to investigate whether these observations will result in a lower inflammatory burden of hemodialysis patients.

Complement Activation by Human Lymphocytes from Different Lymphoid Organs: Role of Sialic Acid and Lack of Relationship to Electrical Surface Charge

Complement ◽  
1987 ◽  
Vol 4 (2) ◽  
pp. 99-109 ◽  
Author(s):  
Carmen Gutierrez ◽  
Maria J. Martin ◽  
K.A. Brown
Keyword(s):  
Sialic Acid ◽  
Surface Charge ◽  
Complement Activation ◽  
Human Lymphocytes ◽  
Lymphoid Organs

scholarly journals Biocompatibility of dialysis membranes: Effects of chronic complement activation

1984 ◽  
Vol 26 (2) ◽  
pp. 194-200 ◽  
Author(s):  
Raymond M. Hakim ◽  
Douglas T. Fearon ◽  
J. Michael Lazarus ◽  
Cynthia S. Perzanowski
Keyword(s):  
Complement Activation ◽  
Dialysis Membranes

Polymorphonuclear Oxygen Free Radical Production and Complement Activation Induced by Dialysis Membranes as Assayed in an Experimental Model

1989 ◽  
Vol 7 (6) ◽  
pp. 293-300 ◽  
Author(s):  
Gianni Cappelli ◽  
Leonardo Lucchi ◽  
Decenzio Bonucchi ◽  
Anna Maria Cenci ◽  
Giuliano Montagnani ◽  
...  
Keyword(s):  
Free Radical ◽  
Experimental Model ◽  
Complement Activation ◽  
Oxygen Free Radical ◽  
Free Radical Production ◽  
Radical Production ◽  
Dialysis Membranes

Complement Activation and Hypersensitivity Reactions to Dialysis Membranes

1984 ◽  
Vol 311 (14) ◽  
pp. 878-882 ◽  
Author(s):  
Raymond M. Hakim ◽  
Julian Breillatt ◽  
J. Michael Lazarus ◽  
Friedrich K. Port
Keyword(s):  
Complement Activation ◽  
Hypersensitivity Reactions ◽  
Dialysis Membranes

scholarly journals Specific adsorption of some complement activation proteins to polysulfone dialysis membranes during hemodialysis

2009 ◽  
Vol 76 (4) ◽  
pp. 404-413 ◽  
Author(s):  
Jan Mares ◽  
Visith Thongboonkerd ◽  
Zdenek Tuma ◽  
Jiri Moravec ◽  
Martin Matejovic
Keyword(s):  
Complement Activation ◽  
Specific Adsorption ◽  
Dialysis Membranes

Risk Factors for Secondary Membrane Formation After Pediatric Cataract

2002 ◽  
Vol 28 (11) ◽  
pp. 1898
Author(s):  
Mayank S. Pangtey ◽  
Sudarshan Khokhar
Keyword(s):  
Risk Factors ◽  
Pediatric Cataract ◽  
Membrane Formation ◽  
Secondary Membrane

scholarly journals Complement activation by cellulosic dialysis membranes.

1994 ◽  
Vol 47 (2) ◽  
pp. 155-158 ◽  
Author(s):  
A Innes ◽  
A M Farrell ◽  
R P Burden ◽  
A G Morgan ◽  
R J Powell
Keyword(s):  
Complement Activation ◽  
Dialysis Membranes

Leukopenia and Complement Activation Induced by Different Dialysis Membranes

2015 ◽  
pp. 142-148 ◽  
Author(s):  
N. K. Man ◽  
N. Q. Tien ◽  
P. Lesavre ◽  
J. -L. Funck-Brentano
Keyword(s):  
Complement Activation ◽  
Dialysis Membranes
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