Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity

Purpose: To report a case of Purtscher-like retinopathy due to atypical hemolytic uremic syndrome and the changes seen in the optical coherence tomography angiography before and after treatment with eculizumab. Case description: A 22-year-old man with an unremarkable medical history presented with acute, bilateral blurred vision and headache of 1-week duration. Best corrected visual acuity of 20/50 and 20/40, respectively, in the patient’s right eye and left eye. Funduscopy revealed multiple cotton-wool spots associated with intrarretinal fluid. Swept source optical coherence tomography revealed multifocal retinal detachments with increased choroidal thickness. Optical coherence tomography angiography showed areas of ischemia in both capillary plexus. Due to concurrent symptoms and laboratory analysis, he was diagnosed with atypical hemolytic uremic syndrome and secondary Purtscher-like retinopathy; therefore, treatment with eculizumab was initiated. After 2 months revascularization of the previous ischemic areas was seen in the optical coherence tomography angiography that were correlated with best corrected visual acuity improvement. Conclusion: Our findings suggest that evaluation of the macular capillary plexus revascularization by optical coherence tomography angiography during the disease could help to predict an improvement of best corrected visual acuity in these patients and the measurement of choroidal thickness could give us information about the resolution of the pathologic process.

Download Full-text

Correlations between visual acuity and macular microvasculature quantified with optical coherence tomography angiography in diabetic macular oedema

Eye ◽

10.1038/s41433-019-0549-1 ◽

2019 ◽

Vol 34 (3) ◽

pp. 544-552 ◽

Cited By ~ 3

Author(s):

Chia-Chieh Hsiao ◽

Chung-May Yang ◽

Chang-Hao Yang ◽

Tzyy-Chang Ho ◽

Tso-Ting Lai ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Oedema ◽

Optical Coherence Tomography Angiography ◽

Diabetic Macular Oedema ◽

Optical Coherence

Download Full-text

The Role of Optical Coherence Tomography Angiography in Ranibizumab-Treated Choroidal Neovascularization in Choroidal Osteoma

Case Reports in Ophthalmology ◽

10.1159/000508032 ◽

2020 ◽

Vol 11 (2) ◽

pp. 370-376

Author(s):

William J. Carroll ◽

Yi Stephanie Zhang ◽

Lee M. Jampol ◽

Manjot K. Gill

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Choroidal Neovascularization ◽

Optical Coherence Tomography Angiography ◽

Initial Evaluation ◽

Optical Coherence ◽

Choroidal Osteoma ◽

Anti Vegf ◽

Subsequent Response ◽

Intraretinal Fluid

In this study, we report the initial evaluation of choroidal neovascularization (CNV) secondary to choroidal osteoma and subsequent response to anti-vascular endothelial growth factor (anti-VEGF) treatment monitored with optical coherence tomography angiography (OCT-A). A 38-year-old female presented with an initial visual acuity of 20/150 in the left eye. Clinical examination revealed a choroidal osteoma. OCT demonstrated both subretinal and intraretinal fluid. OCT-A was performed and showed CNV. A course of ten treatments with ranibizumab showed an improvement of visual acuity to 20/30–3, improvement of subretinal and intraretinal fluid, as well as attenuation of CNV. Our report demonstrates OCT-A as a useful tool for both initial evaluation of CNV and following treatment response to anti-VEGF therapy.

Download Full-text

Rapid response to systemic steroid in macular alexandrite laser exposure: Multimodal imaging

European Journal of Ophthalmology ◽

10.1177/1120672120924346 ◽

2020 ◽

pp. 112067212092434

Author(s):

Melike Balikoglu-Yilmaz ◽

Mahmut Kaya ◽

Murat Erbezci ◽

Suleyman Kaynak

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Visual Field ◽

Visual Field Defect ◽

Optical Coherence Tomography Angiography ◽

Hair Removal ◽

Optical Coherence ◽

Alexandrite Laser ◽

Laser Hair Removal ◽

Field Defect

Purpose To report the management of accidental macular photocoagulation during a 750-nm Alexandrite laser hair removal procedure. Methods Single case report with images. Results A 23-year-old girl presented with an immediate visual field defect in her right eye after direct inadvertent exposure to a single discharge from a 750-nm Alexandrite laser used for laser hair removal. Baseline Snellen visual acuity was 20/20 in the involved right eye but the patient reported a subjective visual field defect. She was treated with oral methylprednisolone that was started at a dose of 1 mg/kg/day and then gradually reduced. Six months after the initial exposure, the final visual acuity was 20/20 and there was a significant improvement in the macular lesion. However, the subjective visual field defect continued. She underwent multimodal retinal imaging with optical coherence tomography, fundus fluorescence angiography, and optical coherence tomography angiography in addition to a visual field test and microperimety. Conclusion The present case documents a gradual visual and anatomical improvement following macular photic damage after accidental occupational exposure to a 750-nm Alexandrite laser. The treatment should be arranged according to the localization of the laser damage. Optical coherence tomography angiography also has the potential to help noninvasively detect choriocapillaris damage.

Download Full-text

Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in retinitis pigmentosa

Clinical Ophthalmology ◽

10.2147/opth.s50752 ◽

2013 ◽

pp. 2073 ◽

Cited By ~ 5

Author(s):

Marilita Moschos ◽

Irini Chatziralli ◽

George Verriopoulos ◽

Aristeides Triglianos ◽

Dimitrios Ladas ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Retinitis Pigmentosa ◽

Multifocal Electroretinogram ◽

Optical Coherence

Download Full-text

Optical coherence tomography angiography findings in patients undergoing transcorneal electrical stimulation for treating retinitis pigmentosa

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-020-04963-7 ◽

2020 ◽

Author(s):

Olga Zabek ◽

Hanna Camenzind Zuche ◽

Ursula Müller ◽

Hendrik P. N. Scholl ◽

Annekatrin Rickmann ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Electrical Stimulation ◽

Retinitis Pigmentosa ◽

Optical Coherence Tomography Angiography ◽

Statistical Significance ◽

Vascular Density ◽

Optical Coherence ◽

Transcorneal Electrical Stimulation ◽

Retinal Layers ◽

Perfusion Density

Abstract Purpose Transcorneal electrical stimulation (TES) is a novel treatment approach for patients with retinitis pigmentosa (RP). The aim of our study was to observe changes in optical coherence tomography angiography (OCTA) that would be attributed to TES treatment. Methods A total of 73 eyes were included: 43 eyes of 22 subjects (11 ♀, 11 ♂) suffering from RP were examined at baseline (BL), after first stimulation (TS), 1 week (1W), and 6 months (6M) after treatment initiation and were compared with 30 control eyes of 15 subjects (8 ♀, 7 ♂). TES was performed simultaneously on both eyes for 30 min weekly. OCTA scans of 9 × 15 mm were recorded with a PLEX Elite 9000 swept-source OCTA device (Carl Zeiss Meditec AG, Jena). Vascular density metrics such as perfusion density (PD) and vessel density (VD) were calculated automatically for the macular area by using standardised extended early treatment diabetic retinopathy study (ETDRS) grids centred around the fovea. In addition, the capillary perfusion density (CPD) and the capillary flux index (CFI) of the peripapillary nerve fibre layer microvasculature in all four quadrants of an annulus centred at the optic disc were measured. All parameters were determined over all retinal layers and separately for the superficial (SCP) and deep capillary plexus (DCP). ANOVA-based linear mixed-effects models were calculated with SPSS®. Results Throughout the course of TES treatment, the macular VD and PD of all retinal layers in all subsections showed a slight decrement without reaching statistical significance, also when analysed separately in the SCP and DCP (p > 0.08). In analogy, the average CPD and CFI also presented with a slight decrement (p > 0.20). However, when compared with controls, most OCTA parameters showed a significant decrement (p < 0.05). When analysed systematically in all subsections of the extended ETDRS grid, the temporal macular subsections within the outer ring (radius 1.5–3 mm) and also of the peripheral C1, C2, and C3 rings (radius 3–7.5 mm) showed lower VD and PD values when compared with the other subsections (p < 0.05). Conclusion Vascular density metrics in the macular region and the peripapillary microvasculature appear to remain unaffected by continuous TES treatment within a period of 6 months.

Download Full-text