Preparation of Blueberry Anthocyanin Nanoemulsion And Its Stability and Skin Safety Evaluation

BACKGROUND: Blueberry anthocyanins have strong antioxidant activity, but their instability and low bioavailability limit their use. Nanoemulsion is a new type of food and drug carrier with stable thermodynamic properties. Therefore, anthocyanins will be encapsulated with nanoemulsion to improve its stability and application value.RESULTS: In this study, the best surfactants, oil phases and cosurfactants for the preparation of blueberry anthocyanin nanoemulsion were screened by pseudo-ternary phase diagram method and the solubility of blueberry anthocyanin nanoemulsion was taken into consideration. Deep purplish red, clear and transparent anthocyanin nanoemulsion was prepared by simple and cheap low-energy emulsification method according to the formula. Normal and high temperature test and high speed centrifugal test proved that the blueberry anthocyanin nanoemulsion had good stability. Guinea pig skin irritation test and sensitization test showed that there was no irritation and sensitization to guinea pig hair removal skin. CONCLUSION: The blueberry anthocyanin nanoemulsion prepared in this study has good stability at room temperature and is safe for guinea pig hair removal skin. It provides a basis for improving the stability and bioavailability of blueberry anthocyanin, and provides a reference for the application of blueberry anthocyanin nanoemulsion in skin beauty and transdermal drug delivery.

A Case Report of Vitiligo Induced by Alexandrite Hair Removal Laser

Vitiligo is one of the disorders where we usually see Koebner lesions. Lasers target a chromophore in the skin to deliver their energy. Their effect is theoretically considered as injury and may induce Koebner lesions in vitiligo patients. Few cases were reported with the different kinds of laser, including laser hair removal (LHR). No cases have ever been reported of vitiligo lesions induced by Alexandrite LHR. Here we present a case report of a young female patient who had never had vitiligo until she received a 755-nm LHR treatment. These vitiligo lesions were completely treated with NB-UVB with no recurrence until 4 years later when she received another 755-nm LHR treatment session with a different machine, which lead to new vitiligo patches only on the areas that received the laser.

IMPORTANCE OF HAIR GROWTH IN HISUTISM: DIAGNOSIS AND TREATMENT

The objective of the review is to explain the pathogenesis, causes and various treatment involved in hirsutism. This article discusses the disease’s pathogenesis, causes and diagnosis. This review looks at the main significant type of hairs and clinical studies on the role of several lifestyle therapies in hirsutism development. This review examines the numerous methods that causes hirsutism in order to discover new medicaments. In addition, it covers the various type of hirsutism therapy. Hirsutism, is reported to have the strongest impact on patients’ health-related quality of life, following in descending order by body mass index, irregular menses, and infertility. To assess the types of hairs and pathogenesis, sign and symptoms, as well as causes of hirsutism. Moreover, we studied the management of hirsutism and how to treat this. At least six to nine months of therapy are required to produce improvement in hirsutism. We suggest testing for elevated androgen levels in women with moderate or severe hirsutism or hirsutism of any degree when it is sudden in onset, rapidly progressive, or associated with other abnormalities such as menstrual dysfunction, obesity, or macroclitoris. For women with patient-important hirsutism despite cosmetic measures, we suggest either pharmacological therapy or direct hair removal methods. For pharmacological therapy, we suggest oral contraceptives for the majority of women, adding an Antiandrogens after 6 mo if the response is suboptimal. We recommend against androgen antagonist monotherapy unless adequate contraception is used. We suggest against using insulin-lowering drugs. For women who choose hair removal therapy, we suggest laser/photo epilation.

The use of acetic acid thallium in fungal diseases

The huge spread of fungal diseases in the USSR forces us to look for affordable methods of treatment that could be applied in the areas most affected. Medical treatment with various disinfecting ointments without hair removal does not achieve the goal, while conventional hair removal with tweezers is possible only in cases with sharply limited and small lesions. The use of X-ray therapy is not always available due to the lack of a sufficient number of X-ray units, and not in all cases this therapy can be carried out. Therefore, the method of hair removal with thallium acetate, proposed by Buschke, aroused great interest.

Properties and parameters for effective laser hair removal: A review

Because some people seek consultations for the removal of unwanted body hair, a permanent, safe, and non-invasive method of hair removal is needed. Laser hair removal has been a popular cosmetic procedure. It is a monthly treatment that may take up to ten sessions for permanent results. However, its efficacy varies due to the patient’s biological skin hair traits, the adjustment of the optimal parameters of the laser, and the protocols. The purpose of this review is to discuss the properties and parameters employed for laser hair removal. Once parameters for laser hair removal have been optimized, this treatment offers an effective and permanent solution for unwanted body hair.

Paradoxical Hypertrichosis after Laser Therapy

OBJECTIVES: In numerous cultures, unwanted hair is considered a common aesthetic problem. For hair removal, the use of lasers is a common medical procedure that is comparatively safe and has few side effects. Paradoxical hypertrichosis has been reported rarely in previous studies. The aim of this study was to find out the frequency of paradoxical hypertrichosis after laser treatment. METHODOLOGY: This cross sectional study was done for a period of one year from January 2020 to January 2021. This study was conducted at Al-Shifa Clinic and Skin Aesthetic, Nowshera, Khyber Pakhtunkhwa. All those patients who go-through the laser hair removal were included in the study. Diode laser with 808nm wavelength was used. All the patients were observed for paradoxical hypertrichosis after laser treatment. RESULTS: Total 140 patients underwent laser hair removal during a one-year study. There were 120 females and 20 male in our study. The mean age of male was 28±1.2 while the mean age of females was 26±1.4. Amongst 140 patients, the overall prevalence of paradoxical hypertrichosis after laser treatment was 7.8% (n=11). This side effect was observed dominantly on the neck and face. Skin phototype III and 1V were observed with this side effect. CONCLUSION: Our research study concludes that paradoxical hypertrichosis occurs rarely after laser therapy. Study with high sample size and risk factors should be done for better understanding.

Evolution and advances of laser hair removal technologies in India

Laser hair removal is the treatment of choice by dermatologists to treat excessive, unwanted hair on body. A dermatologist most often invests it as the first laser in their clinical and esthetic set up. A thorough and updated knowledge of laser hair removal is required to invest in the best machine available and to provide best results to patients. This article will provide knowledge on what is the latest in terms of technological advancement in laser hair removal.