Liver collagen in cirrhosis correlates with portal hypertension and liver dysfunction

Apmis ◽  
2014 ◽  
Vol 122 (12) ◽  
pp. 1213-1222 ◽  
Author(s):  
Kåre Nielsen ◽  
Jens Otto Clemmesen ◽  
Efstathios Vassiliadis ◽  
Ben Vainer
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Liver Collagen

The evaluation of liver dysfunction: When to suspect portal hypertension

2009 ◽  
Vol 22 (4) ◽  
pp. 38-42 ◽  
Author(s):  
Amy Singletary Moan
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction

Idiopathic portal hypertension associated with high serum titer of antoantibodies and liver dysfunction

1996 ◽  
Vol 31 (1) ◽  
pp. 123-128 ◽  
Author(s):  
Katsuhito Mori ◽  
Eiyi Ishimura ◽  
Hitoshi Goto ◽  
Shigeichi Shoji ◽  
Shuichi Seki ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Idiopathic Portal Hypertension ◽  
High Serum ◽  
Serum Titer

Retrospective analysis of ultrasound and dopplerographic parameters of liver hemodynamics in prognosis of mortality in patients with severe concomitant injury

2021 ◽  
pp. 55-62
Author(s):  
O. A. Alekseechkina ◽  
L. T. Khamidova ◽  
A. K. Shabanov ◽  
G. P. Titova ◽  
V. Ya. Kiselevskaya-Babinina
Keyword(s):  
Blood Flow ◽  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Traumatic Shock ◽  
Time Range ◽  
Stepwise Logistic Regression ◽  
Concomitant Injury ◽  
Probability Of Death ◽  
Liver Hemodynamics ◽  
The Moment

Purpose. According to the assessment of liver hemodynamics, to determine the criteria for the probability of death in patients with severe concomitant injury and to establish the decisive time range in which these indicators are prognostic.Material and methods. The analysis of ultrasound (US) indicators in 57 patients with severe concomitant trauma was carried out in order to identify criteria for the probability of death and determine the time range in which these indicators have a prognostic character. All patients were divided into two groups: the first group of 40 surviving patients; the second of 17 dead. For comparison, three values were taken for each ultrasound indicator on the 1st, 3rd, 5th, 7th days from the moment of admission to the hospital. Comparison of the first and second groups of patients by these parameters revealed signs characterizing the violation of liver hemodynamics. The Mann-Whitney test, correlation analysis and stepwise logistic regression were used to study the relationships. Differences were considered statistically significant at a significance level of p < 0.05. Correlation was considered strong when R > 0.5. The best reliable regression model was chosen according to the highest value of the Akaike criterion.Results. In the first three days after trauma in patients of the first and second groups, the most significant were such ultrasound signs as a decrease in the diameter of the own hepatic artery (OHA), a decrease in the linear blood flow velocity (LBFV) along the SPA to 27–38 cm/s, and a decrease in volumetric blood flow in OHA, an increase in the index of resistance (IR) in OHA of more than 0.7, in combination, indicate liver dysfunction in patients in a state of traumatic shock. From the 5th day in the second group of patients, an increase in LBFV in the OHA (100–135 cm/s), an increase of 0.70–0.84, a decrease in volumetric blood flow less than 270 ml/min indicate violations of liver hemodynamics during the formation of organ dysfunction. On the 5–7th day, due to edema of the liver parenchyma against the background of an increase in the size of the liver and spleen and the formation of portal hypertension, arterialization of blood circulation occurs, which is characterized by a significant increase in LBFV in the OHA, a decrease in LBFV and volumetric blood flow in the portal vein. The third-fifth day after the injury can be considered a turning point – the correlation of most of the indicators with the fact of death and significant differences in the criterion in 9 out of 11 indicators indicate significant differences in all indicators in patients of the first and second groups. At the same time, not only dopplerographic indicators of hepatic blood flow, but also linear indicators of the size of the liver, spleen, signs of portal hypertension characterize the severity of the patient’s condition. Findings. 1). Carrying out an ultrasound of the liver with the use of Doppler ultrasound allows in the first 3 days from the moment of injury to conclude that there is liver dysfunction against the background of traumatic shock. 2). Statistical analysis of Doppler parameters of liver hemodynamics makes it possible to identify patients with a poor prognosis, severe liver dysfunction in the first 3–5 days from the moment of injury, as well as with developing multiple organ failure. 3). The obtained ultrasound results, indicating liver dysfunction in the early post-traumatic period, are confirmed by autopsy data.

710 TIMP-1 IN PATIENTS WITH CIRRHOSIS: RELATION TO LIVER DYSFUNCTION, PORTAL HYPERTENSION, AND HAEMODYNAMIC CHANGES

2013 ◽  
Vol 58 ◽  
pp. S288-S289
Author(s):  
T.M. Busk ◽  
F. Bendtsen ◽  
V. Jensen ◽  
H.J. Nielsen ◽  
N. Brünner ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Haemodynamic Changes

scholarly journals Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension

2018 ◽  
Vol 38 (8) ◽  
pp. 1427-1436 ◽  
Author(s):  
Rafael Paternostro ◽  
Birgit B. Heinisch ◽  
Thomas Reiberger ◽  
Mattias Mandorfer ◽  
Remy Schwarzer ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Portal Hypertension ◽  
Arterial Hypertension ◽  
Liver Dysfunction

Hepatic disease

2021 ◽  
pp. 201-214
Author(s):  
Ashleigh Williams ◽  
John Christie
Keyword(s):  
Portal Hypertension ◽  
Liver Disease ◽  
Drug Metabolism ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Liver Dysfunction ◽  
Hepatorenal Syndrome ◽  
Anaesthetic Management ◽  
Hepatic Disease ◽  
Chronic Liver Failure

This chapter describes the anaesthetic management of the patient with liver disease and its sequelae. Acute liver failure and chronic liver failure are discussed, together with their anaesthetic implications on coagulation and drug metabolism. Major sequelae of liver disease are discussed, including portal hypertension, varices, and hepatorenal syndrome. The pre-operative investigation and optimisation, treatment, and anaesthetic management of the patient with liver failure are described. The investigation and management of postoperative liver dysfunction are described.

scholarly journals Portal hypertension is the main driver of liver stiffness in advanced liver cirrhosis

2021 ◽  
pp. 563-577
Author(s):  
Mariia Lunova ◽  
Sona Frankova ◽  
Halima Gottfriedova ◽  
Renata Senkerikova ◽  
Magdalena Neroldova ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Venous Pressure ◽  
Liver Stiffness ◽  
Collagen Content ◽  
Explanted Liver ◽  
Advanced Liver Cirrhosis ◽  
Cirrhotic Patients ◽  
Liver Collagen

Liver stiffness (LS) is a novel non-invasive parameter widely used in clinical hepatology. LS correlates with liver fibrosis stage in non-cirrhotic patients. In cirrhotic patients it also shows good correlation with Hepatic Venous Pressure Gradient (HVPG). Our aim was to assess the contribution of liver fibrosis and portal hypertension to LS in patients with advanced liver cirrhosis. Eighty-one liver transplant candidates with liver cirrhosis of various aetiologies underwent direct HVPG and LS measurement by 2D shear-wave elastography (Aixplorer Multiwave, Supersonic Imagine, France). Liver collagen content was assessed in the explanted liver as collagen proportionate area (CPA) and hydroxyproline content (HP). The studied cohort included predominantly patients with Child-Pugh class B and C (63/81, 77.8 %), minority of patients were Child-Pugh A (18/81, 22.2 %). LS showed the best correlation with HVPG (r=0.719, p<0.001), correlation of LS with CPA (r=0.441, p<0.001) and HP/Amino Acids (r=0.414, p< 0.001) was weaker. Both variables expressing liver collagen content showed good correlation with each other (r=0.574, p<0.001). Multiple linear regression identified the strongest association between LS and HVPG (p<0.0001) and weaker association of LS with CPA (p = 0.01883). Stepwise modelling showed minimal increase in r2 after addition of CPA to HVPG (0.5073 vs. 0.5513). The derived formula expressing LS value formation is: LS=2.48 + (1.29 x HVPG) + (0.26 x CPA). We conclude that LS is determined predominantly by HVPG in patients with advanced liver cirrhosis whereas contribution of liver collagen content is relatively low.

Changes of the fibrinolytic system in liver dysfunction: role of portal hypertension

1992 ◽  
Vol 67 (1) ◽  
pp. 15-21 ◽  
Author(s):  
J. Lasierra ◽  
F. Bamao ◽  
G. Ceña ◽  
M.J. Aza ◽  
M.J. Morandeira ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Fibrinolytic System

TIMP-1 in patients with cirrhosis: relation to liver dysfunction, portal hypertension, and hemodynamic changes

2014 ◽  
Vol 49 (9) ◽  
pp. 1103-1110 ◽  
Author(s):  
Troels M. Busk ◽  
Flemming Bendtsen ◽  
Hans J. Nielsen ◽  
Vibeke Jensen ◽  
Nils Brünner ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Dysfunction ◽  
Hemodynamic Changes
Sign in / Sign up

Export Citation Format

Share Document