scholarly journals Systematic review: the combined surgical and medical treatment of fistulising perianal Crohn's disease

2014 ◽  
Vol 40 (7) ◽  
pp. 741-749 ◽  
Author(s):  
N. A. Yassin ◽  
A. Askari ◽  
J. Warusavitarne ◽  
O. D. Faiz ◽  
T. Athanasiou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Medical Treatment ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease

Medical and surgical management of pediatric perianal crohn's disease: A systematic review

2019 ◽  
Vol 54 (12) ◽  
pp. 2554-2558 ◽  
Author(s):  
Victoria K. Forsdick ◽  
Sharman P. Tan Tanny ◽  
Sebastian K. King
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Surgical Management ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease

Medical Treatment of Perianal Crohn’s Disease

2015 ◽  
pp. 49-58
Author(s):  
Ambrogio Orlando ◽  
Sara Renna ◽  
Gaspare Solina ◽  
Mario Cottone
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Medical Treatment ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease

scholarly journals Systematic review with meta-analysis: faecal diversion for management of perianal Crohn's disease

2015 ◽  
Vol 42 (7) ◽  
pp. 783-792 ◽  
Author(s):  
S. Singh ◽  
N. S. Ding ◽  
K. L. Mathis ◽  
P. S. Dulai ◽  
A. M. Farrell ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Perianal Crohn’S Disease ◽  
Faecal Diversion ◽  
Perianal Crohn's Disease

Endpoints for Perianal Crohn’s Disease Trials: Past, Present and Future

2021 ◽  
Author(s):  
Bénédicte Caron ◽  
Ferdinando D’Amico ◽  
Silvio Danese ◽  
Laurent Peyrin-Biroulet
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Clinical Response ◽  
Primary Endpoint ◽  
Randomized Clinical Trials ◽  
Controlled Trials ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease

Abstract Background and Aims Since the 1980s, many studies have evaluated the efficacy of therapies to improve the outcomes of patients with perianal Crohn’s disease. We performed a systematic review to describe the evolution of endpoints in perianal fistulizing Crohn’s disease. Efficacy outcomes, definitions and measurement tools were assessed. Methods Electronic databases were searched up to November 1, 2020. All published randomized placebo-controlled trials enrolling patients with perianal fistula and Crohn’s disease were eligible for inclusion. Ongoing randomized clinical trials were also described. Results Nineteen randomized controlled trials were included. Clinical efficacy endpoints were reported in all trials. Clinical response was the most frequent primary endpoint [6/19 studies, 31.6%], followed by clinical remission in four studies [21%]. Clinical response was defined as closure of at least 50% of fistulas, while remission was defined as closure of all fistulas. A combined clinical and radiological primary endpoint was used to assess fistula healing in four studies [21%]. The Perianal Disease Activity Index was a primary endpoint in only one study [5.5%]. In addition, eight ongoing controlled trials were identified. Combined clinical and radiological remission was the most frequent primary endpoint in these studies [4/8, 50%]. Conclusion In this systematic review, significant changes in outcomes used in randomized clinical trials of perianal Crohn’s disease were observed. Radiological endpoints are increasingly used in perianal fistulizing Crohn’s disease trials.

scholarly journals P245 A systematic review of outcomes reported in studies on fistulising perianal Crohn's disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S202-S202 ◽  
Author(s):  
K. Sahnan ◽  
S.O. Adegbola ◽  
P.J. Tozer ◽  
B.S.R. Allin ◽  
M.J. Lee ◽  
...  
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease

Imaging Modalities for Perianal Crohn’s Disease

2012 ◽  
Vol 13 (10) ◽  
pp. 1287-1293 ◽  
Author(s):  
Antonino Spinelli ◽  
Chiara De Cassan ◽  
Matteo Sacchi ◽  
Piero Bazzi ◽  
Silvio Danese ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Imaging Modalities ◽  
Perianal Crohn’S Disease ◽  
Perianal Crohn's Disease
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