scholarly journals Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects

2016 ◽  
Vol 83 (2) ◽  
pp. 326-338 ◽  
Author(s):  
William S. Denney ◽  
Gabriele E. Sonnenberg ◽  
Santos Carvajal-Gonzalez ◽  
Theresa Tuthill ◽  
V. Margaret Jackson
Keyword(s):  
Healthy Subjects ◽  
Inverse Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Ghrelin Receptor ◽  
Receptor Inverse Agonist

scholarly journals Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach

2019 ◽  
Vol 47 (8) ◽  
pp. 874-882 ◽  
Author(s):  
Sravani Adusumalli ◽  
Rohitash Jamwal ◽  
R. Scott Obach ◽  
Tim F. Ryder ◽  
Lorenzo Leggio ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
The Novel ◽  
Ghrelin Receptor ◽  
Receptor Inverse Agonist

Influence of taranabant, a cannabinoid-1 receptor inverse agonist, on pharmacokinetics and pharmacodynamics of warfarin

2008 ◽  
Vol 25 (11) ◽  
pp. 1175-1190 ◽  
Author(s):  
Jules I. Schwartz ◽  
Stephanie Dunbar ◽  
Jinyu Yuan ◽  
Susie Li ◽  
Adrianna Gipson ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist

scholarly journals Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

2014 ◽  
Vol 5 (5) ◽  
pp. 474-479 ◽  
Author(s):  
Samit K. Bhattacharya ◽  
Kim Andrews ◽  
Ramsay Beveridge ◽  
Kimberly O. Cameron ◽  
Chiliu Chen ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Orally Bioavailable ◽  
Receptor Inverse Agonist ◽  
Clinical Candidate

C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism

Biopolymers ◽  
2016 ◽  
Vol 106 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Sylvia Els-Heindl ◽  
Kathrin Bellmann-Sickert ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Inverse Agonism ◽  
C Terminus ◽  
Receptor Inverse Agonist

Multiple-Dose Safety, Pharmacokinetics, and Pharmacodynamics of the μ-Opioid Receptor Inverse Agonist GSK1521498

2012 ◽  
Vol 52 (10) ◽  
pp. 1456-1467 ◽  
Author(s):  
Pradeep J. Nathan ◽  
Mark A. Bush ◽  
Wenli X. Tao ◽  
Annelize Koch ◽  
Kirsty M. Davies ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Multiple Dose ◽  
Inverse Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Μ Opioid Receptor ◽  
Receptor Inverse Agonist

Pharmacokinetics of digoxin in healthy subjects receiving taranabant, a novel cannabinoid-1 receptor inverse agonist

2009 ◽  
Vol 26 (2) ◽  
pp. 230-240 ◽  
Author(s):  
Andrew E. Denker ◽  
Gaetano Morelli ◽  
Laura K. Vessey ◽  
Susie Li ◽  
Jinyu Yuan ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Inverse Agonist ◽  
Cannabinoid 1 Receptor ◽  
Receptor Inverse Agonist
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