scholarly journals Development and validation of an UPLC-MS/MS assay for quantitative analysis of the ghrelin receptor inverse agonist PF-5190457 in human or rat plasma and rat brain

2015 ◽  
Vol 407 (19) ◽  
pp. 5603-5613 ◽  
Author(s):  
Mwlod Ghareeb ◽  
Lorenzo Leggio ◽  
Ayman El-Kattan ◽  
Fatemeh Akhlaghi
Keyword(s):  
Quantitative Analysis ◽  
Rat Brain ◽  
Rat Plasma ◽  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Development And Validation ◽  
Receptor Inverse Agonist

scholarly journals Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach

2019 ◽  
Vol 47 (8) ◽  
pp. 874-882 ◽  
Author(s):  
Sravani Adusumalli ◽  
Rohitash Jamwal ◽  
R. Scott Obach ◽  
Tim F. Ryder ◽  
Lorenzo Leggio ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
The Novel ◽  
Ghrelin Receptor ◽  
Receptor Inverse Agonist

scholarly journals Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects

2016 ◽  
Vol 83 (2) ◽  
pp. 326-338 ◽  
Author(s):  
William S. Denney ◽  
Gabriele E. Sonnenberg ◽  
Santos Carvajal-Gonzalez ◽  
Theresa Tuthill ◽  
V. Margaret Jackson
Keyword(s):  
Healthy Subjects ◽  
Inverse Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Ghrelin Receptor ◽  
Receptor Inverse Agonist

scholarly journals Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate

2014 ◽  
Vol 5 (5) ◽  
pp. 474-479 ◽  
Author(s):  
Samit K. Bhattacharya ◽  
Kim Andrews ◽  
Ramsay Beveridge ◽  
Kimberly O. Cameron ◽  
Chiliu Chen ◽  
...  
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Orally Bioavailable ◽  
Receptor Inverse Agonist ◽  
Clinical Candidate

C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behavior from inverse agonism to agonism

Biopolymers ◽  
2016 ◽  
Vol 106 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Sylvia Els-Heindl ◽  
Kathrin Bellmann-Sickert ◽  
Annette G. Beck-Sickinger
Keyword(s):  
Inverse Agonist ◽  
Ghrelin Receptor ◽  
Inverse Agonism ◽  
C Terminus ◽  
Receptor Inverse Agonist
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