scholarly journals Innovative approaches and recent advances in the study of ontogeny of drug metabolism and transport

2020 ◽  
Author(s):  
Bianca D. Groen ◽  
Karel Allegaert ◽  
Dick Tibboel ◽  
Saskia N. Wildt
Keyword(s):  
Drug Metabolism ◽  
Recent Advances ◽  
Innovative Approaches

Considerations and recent advances in QSAR models for cytochrome P450-mediated drug metabolism prediction

2008 ◽  
Vol 22 (11) ◽  
pp. 843-855 ◽  
Author(s):  
Haiyan Li ◽  
Jin Sun ◽  
Xiaowen Fan ◽  
Xiaofan Sui ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Recent Advances ◽  
Qsar Models ◽  
Drug Metabolism Prediction

scholarly journals Cytochrome P450 enzymes: understanding the biochemical hieroglyphs

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 178 ◽  
Author(s):  
John T. Groves
Keyword(s):  
Cytochrome P450 ◽  
Drug Metabolism ◽  
Reactive Intermediates ◽  
Heme Iron ◽  
Cytochrome P450 Enzymes ◽  
Steroid Biosynthesis ◽  
Reaction Cycle ◽  
Cyp Enzymes ◽  
Protein Architecture ◽  
Recent Advances

Cytochrome P450 (CYP) enzymes are the primary proteins of drug metabolism and steroid biosynthesis. These crucial proteins have long been known to harbor a cysteine thiolate bound to the heme iron. Recent advances in the field have illuminated the nature of reactive intermediates in the reaction cycle. Similar intermediates have been observed and characterized in novel heme-thiolate proteins of fungal origin. Insights from these discoveries have begun to solve the riddle of how enzyme biocatalyst design can afford a protein that can transform substrates that are more difficult to oxidize than the surrounding protein architecture.

scholarly journals Ontogeny of drug metabolism and transport: new data derived by innovative approaches

2020 ◽  
Author(s):  
Bianca van Groen ◽  
Karel Allegaert ◽  
Dick Tibboel ◽  
Saskia De wildt
Keyword(s):  
Drug Metabolism ◽  
Innovative Approaches

Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

2021 ◽  
Author(s):  
Riccardo Ronchetti ◽  
Giada Moroni ◽  
Andrea Carotti ◽  
Antimo Gioiello ◽  
Emidio Camaioni
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Recent Advances ◽  
Privileged Structures ◽  
Innovative Approaches

Urea and thiourea represent privileged structures in medicinal chemistry.

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