Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF

2017 ◽  
Vol 42 (8) ◽  
pp. 874-880 ◽  
Author(s):  
A. M. Abreu-Velez ◽  
C. A. Valencia-Yepes ◽  
Y. A. Upegui-Zapata ◽  
E. Upegui-Quiceno ◽  
N. R. Mesa-Herrera ◽  
...  
Keyword(s):  
Pemphigus Foliaceus ◽  
Arrector Pili Muscle ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

Broad histopathologic patterns of non-glabrous skin and glabrous skin from patients with a new variant of endemic pemphigus foliaceus-part 1

2010 ◽  
Vol 37 (2) ◽  
pp. 222-230 ◽  
Author(s):  
Michael S. Howard ◽  
Maria M. Yepes ◽  
Juan G. Maldonado-Estrada ◽  
Edinson Villa-Robles ◽  
Andrés Jaramillo ◽  
...  
Keyword(s):  
Glabrous Skin ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

scholarly journals Cardiac Autoantibodies from Patients Affected by a New Variant of Endemic Pemphigus Foliaceus in Colombia, South America

2011 ◽  
Vol 31 (6) ◽  
pp. 985-997 ◽  
Author(s):  
Ana Maria Abreu-Velez ◽  
Michael S. Howard ◽  
Zhe Jiao ◽  
Weiqing Gao ◽  
Hong Yi ◽  
...  
Keyword(s):  
South America ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

scholarly journals Involvement of the Areae Compositae of the Heart in Endemic Pemphigus Foliaceus

2019 ◽  
pp. 181-186
Author(s):  
Ana Maria Abreu-Velez ◽  
Yulieth A. Upegui-Zapata ◽  
Carlos A. Valencia-Yepes ◽  
Eduardo Upegui-Quiceno ◽  
Alejandra M. Jiménez-Echavarría ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Usher Syndrome ◽  
Left Ventricular ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus ◽  
Microscopic Studies ◽  
Antigenic Reactivity ◽  
Control Study

Background: A new variant of endemic pemphigus foliaceus in El Bagre (El Bagre-EPF), Colombia, South America, shares features with Senear-Usher syndrome and occurs in an endemic fashion. Patients affected by El Bagre-EPF have heterogeneous antigenic reactivity not only to the skin but to other organs, including the heart. Here we test for autoantibodies to the areae compositaeof the heart (structure consisting of typical desmosomal amalgamated fascia adherensmolecules)and evaluate any possible clinical correlation. Methods: A case-control study comparing 45 patients and 45 controls from the endemic area, matched by demographics including age, gender, weight, work activities, and comorbidities, was performed. Direct and indirect immunofluorescence, immunohistochemistry, confocal microscopic studies, and echocardiogram studies were completed. Results: The main clinical abnormally seen in the El Bagre-EPF patients was left ventricular hypertrophy in 15/45 patients, compared with no such findings in the control population (P < 0.1). Seventy percent of El Bagre-EPF patients and none of the controls displayed polyclonal autoreactivity using different immunoglobulins and complement to the areae compositae of the heart using different methods and antibodies (P < 0.1). Conclusions: Patients affected by El Bagre-EPF demonstrated autoantibodies to the areae compositae of the heart. This finding was associated with left ventricular hypertrophic cardiomyopathy.The areae compositaemay play a role incell junction tension and the El Bagre-EPF patients’ autoantibodies possibly disrupting these junctions and thereby contributing to the left ventricular hypertrophy.

Autoantibodies to melanocytes and characterization of melanophages in patients affected by a new variant of endemic pemphigus foliaceus

2011 ◽  
Vol 38 (9) ◽  
pp. 710-719 ◽  
Author(s):  
Ana Maria Abreu Velez ◽  
Hong Yi ◽  
Paul B. Googe ◽  
Martin C. Mihm ◽  
Michael S. Howard
Keyword(s):  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

scholarly journals Neural System Antigens Are Recognized by Autoantibodies from Patients Affected by a New Variant of Endemic Pemphigus Foliaceus in Colombia

2011 ◽  
Vol 31 (3) ◽  
pp. 356-368 ◽  
Author(s):  
Ana Maria Abreu-Velez ◽  
Michael S. Howard ◽  
Hong Yi ◽  
Weiqing Gao ◽  
Takashi Hashimoto ◽  
...  
Keyword(s):  
Neural System ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

Formalin deposition as artifact in biopsies from patients affected by a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America

2009 ◽  
Vol 37 (8) ◽  
pp. 835-842 ◽  
Author(s):  
Ana Maria Abreu Velez ◽  
Michael S. Howard ◽  
Marcos Restrepo-Isaza ◽  
Bruce Smoller
Keyword(s):  
South America ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus

A new variant of endemic pemphigus foliaceus in Colombia South America

2020 ◽  
Vol 11 (3) ◽  
pp. 284-299
Author(s):  
Ana Maria Abreu Velez ◽  
Yulieth Alexandra Upegui-Zapata ◽  
Carlos Andres Valencia-Yepes ◽  
Eduardo Upegui-Quiceño ◽  
Hong Yi ◽  
...  
Keyword(s):  
South America ◽  
Pemphigus Foliaceus ◽  
New Variant ◽  
Endemic Pemphigus Foliaceus
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